Linh Ho, Allen Sam Titus, Kushal Kr Banerjee, Suji George, Wei Lin, Shaunak Deota, Asish K. Saha, Ken Nakamura, Philipp Gut, Eric Verdin, Ullas Kolthur-Seetharam
Abstract:Efficient coupling of cellular energy production to metabolic demand is crucial to maintain organismal homeostasis. Here, we report that the mitochondrial Sirtuin Sirt4 regulates mitochondrial ATP homeostasis. We find that Sirt4 affects mitochondrial uncoupling via the adenine nucleotide translocator 2 (ANT2). Loss of Sirt4 expression leads to decreased cellular ATP levels in vitro and in vivo while Sirt4 overexpression is associated with increased ATP levels. Further, we provide evidence that lack of Sirt4 ac…
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