volume 10, issue 9, P2498-2510 2018
DOI: 10.18632/aging.101564
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Shuo Qian, Jianlan Gu, Wufei Dai, Nana Jin, Dandan Chu, Qin Huang, Fei Liu, Wei Qian

Abstract: Alternative splicing of tau exon 10 generates tau isoforms with three or four microtubule binding repeats, named 3R-tau and 4R-tau, respectively. Dysregulation of tau exon 10 splicing could cause neurofibrillary degeneration. Acetylation is one of the major post-translational protein modifications in the cell by attachment of the acetyl group to either the α-amino group of the N-terminus of proteins or to the ε-amino group of lysine residues. Sirt1, one member in mammalian Sirtuin family, deacetylates protein …

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