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Cited by 8 publications
(7 citation statements)
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References 10 publications
(7 reference statements)
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“…For example, perhaps the fluorophores reflect a requirement for amino acids near the deacetylation site with aromatic side chains. Indeed, several recent findings have revealed structural and positional requirements: Amino acids must be adjacent to the acetylated lysine for substrate recognition (60) and for activation to occur (81, 82, 115, 116). First, repositioning the AMC group in the substrate peptide from its canonical site immediately C-terminal to the acetylated lysine (+1) to +3, +6, +9, or +12 completely abrogated activation by STACs (81).…”
Section: Toward a Resolution And A Unified Activation Mechanism Targementioning
confidence: 99%
“…For example, perhaps the fluorophores reflect a requirement for amino acids near the deacetylation site with aromatic side chains. Indeed, several recent findings have revealed structural and positional requirements: Amino acids must be adjacent to the acetylated lysine for substrate recognition (60) and for activation to occur (81, 82, 115, 116). First, repositioning the AMC group in the substrate peptide from its canonical site immediately C-terminal to the acetylated lysine (+1) to +3, +6, +9, or +12 completely abrogated activation by STACs (81).…”
Section: Toward a Resolution And A Unified Activation Mechanism Targementioning
confidence: 99%
“…SIRT1 is the most studied molecule of the human sirtuin family and is highly expressed in human endothelial cells and vessels. Previous studies have reported that SIRT1 could regulate inflammation and antiaging in endothelial cells (Kugel & Mostoslavsky, ; Lei, Gu, Ye, Shi, & Zheng, ; Orecchia et al, ; Zarzuelo et al, ). Moreover, it have been previously confirmed that SIRT1 had the effects of antiatherosclerotic in numerous reports using in vitro or in vivo investigations (Hung, Chan, Chu, & Tsai, ; Miranda et al, ; Shentu et al, ; Winnik et al, ).…”
Section: Discussionmentioning
confidence: 97%
“…Moreover, TASAES inhibited ox-LDL-induced HUVECs apoptosis by reducing pro-apoptotic proteins expression and increasing antiapoptotic proteins expression.SIRT1 is the most studied molecule of the human sirtuin family and is highly expressed in human endothelial cells and vessels. Previous studies have reported that SIRT1 could regulate inflammation and antiaging in endothelial cells(Kugel & Mostoslavsky, 2013;Lei,…”
mentioning
confidence: 99%
“…The metabolism-improving effects of RSV have led to extensive efforts to delineate the underlying molecular mechanisms and define its therapeutic potential; several analogs with stronger activity have been derived [32,[91][92][93][94][95][96]. It was shown that SIRT1 and AMPK were activated or upregulated by RSV treatment [21,22,24,46].…”
Section: Resveratrolmentioning
confidence: 99%