2016
DOI: 10.18632/aging.100911 View full text |Buy / Rent full text
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Abstract: The quality of metaphase II oocytes will undergo a time-dependent deterioration following ovulation as the result of the oocyte aging process. In this study, we determined that the expression of sirtuin family members (SIRT1, 2, 3) was dramatically reduced in mouse oocytes aged in vivo or in vitro. Increased intracellular ROS was observed when SIRT1, 2, 3 activity was inhibited. Increased frequency of spindle defects and disturbed distribution of mitochondria were also observed in MII oocytes aged in vitro aft… Show more

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“…The changes in glycolytic markers that we observed in the early premalignant colorectal mucosal field are consistent with changes that have been described in CRC, and these changes would be expected to promote increased glycolysis and shunting of glycolytic intermediates into anabolic pathways [11, 22, 25, 26, 29]. Consistent with an early Warburg Effect, our findings suggest an early increase in glucose uptake ( GLUT1 ) and pyruvate fermentation into lactate ( LDHA ).…”
Section: Discussionsupporting
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…The changes in glycolytic markers that we observed in the early premalignant colorectal mucosal field are consistent with changes that have been described in CRC, and these changes would be expected to promote increased glycolysis and shunting of glycolytic intermediates into anabolic pathways [11, 22, 25, 26, 29]. Consistent with an early Warburg Effect, our findings suggest an early increase in glucose uptake ( GLUT1 ) and pyruvate fermentation into lactate ( LDHA ).…”
Section: Discussionsupporting
“…Mammals have 7 members (Sirt1-Sirt7) displayed differential cellular localization and function in numerous physiologic processes. 15 Among them, Sirt3 is localized in mitochondria and controls the acetylation status of almost 80»90% of mitochondrial proteins. 16 It regulates the production of ROS via the electron transport chain, as well as the detoxification of ROS through activation of antioxidant enzymes.…”
Section: Introductionmentioning
“…16 It regulates the production of ROS via the electron transport chain, as well as the detoxification of ROS through activation of antioxidant enzymes. 15,17,18 Recent studies highlight the critical role of Sirt3 in modulating ROS homeostasis in response to caloric restriction. Sirt3 is able to directly deacetylates isocitrate dehydrogenase 2 (IDH2), increasing the levels of NADPH and thereupon protecting cells from oxidative stress.…”
Section: Introductionmentioning
“…A handful of studies have reported that postovulatory aging is highly correlated with a variety of defects in oocytes, including precocious release of cortical granules, zona pellucida hardening, spindle/chromosome abnormalities, weakened fertilization ability, and abnormal development of embryos and fetuses (5)(6)(7)(8)(9). In addition, postovulatory aging is accompanied by diverse molecular, cellular, and biochemical changes, such as dysfunction of mitochondria, generation of reactive oxygen species (ROS), reduced maturation-promoting factor activities, decreased expression of antiapoptotic factor B-cell lymphoma 2 (BCL-2), activation of caspase-3, and changes in epigenetic modifications (4,(10)(11)(12). These aging-induced deleterious changes have the potential to impair oocyte quality, thereby adversely affecting fertilization and subsequent embryo development.…”
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