Sir Victor Horsley, Mr John Marshall, the Nervi Nervorum, and Pain

Pain in acute motor axonal neuropathy

“…Although the ventral roots, severely affected in AMAN, predominantly consist of efferent somatic motor fibers, the sheaths of the roots have nociceptive endings (nervi nervorum), which may be involved in back pain. [20][21][22] Sonographic and autopsy studies offered an alternative pathophysiological explanation for acute pain in AMAN: early inflammatory edema, located in the anterior spinal roots at the neural foramina, the ventral rami of spinal nerves or both, could involve abutting dorsal rami, thus causing nerve trunk pain referred to their innervation territories. 23 In our study, monotherapy with gabapentin had a poor analgesic effect for low back pain, indicating nociceptive pain.…”

Pain in acute motor axonal neuropathy

“…Although the ventral roots, severely affected in AMAN, predominantly consist of efferent somatic motor fibers, the sheaths of the roots have nociceptive endings (nervi nervorum), which may be involved in back pain. [20][21][22] Sonographic and autopsy studies offered an alternative pathophysiological explanation for acute pain in AMAN: early inflammatory edema, located in the anterior spinal roots at the neural foramina, the ventral rami of spinal nerves or both, could involve abutting dorsal rami, thus causing nerve trunk pain referred to their innervation territories. 23 In our study, monotherapy with gabapentin had a poor analgesic effect for low back pain, indicating nociceptive pain.…”

The evolution and multi-molecular properties of NF1 cutaneous neurofibromas originating from C-fiber sensory endings and terminal Schwann cells at normal sites of sensory terminations in the skin

“…Despite having different timings in their develop and potential to become malignant, an intriguing possibility is that the hyperproliferating SC in pNFs may also be a type of nonmyelinating terminal SC given that both pNFs and cNF have similar histological and functional genomics profiles and both may be derived from BCC lineages. In this case, the SC hyperproliferation in pNFs may involve terminal SC affiliated with arterioles within nerve plexuses that also have innervation, referred to as the nervi nervorum , like that of cutaneous arterioles [36, 118–121].…”

“…The normal expression of GAP-43 among C fibers may be indicative of an ongoing remodeling of their sensory endings and associated terminal glia as part of a normal homeostatic monitoring subliminal maintenance which regularly fluctuates in response to transient tissue stressors, becoming especially exaggerated as part of wound repair [29, 35, 49, 113, 121, 137–141]. As such, the NF1 germinal mutation may compromise the neural/SC cooperativity involved in normal tissue homeostasis.…”

Ultrasound‐Guided Nerve Hydrodissection for Peripheral Entrapment Neuropathies

“…Nerve hydrodissection may exert its effects by releasing pressure on the nervi nervorum and vasa nervorum, which are located outside the epineurium [6,[8][9][10][11][12]. The nervi nervorum regulate the function and discharge of sensory, motor, and mixed nerves.…”

Pain in acute motor axonal neuropathy

“…Although the ventral roots, severely affected in AMAN, predominantly consist of efferent somatic motor fibers, the sheaths of the roots have nociceptive endings (nervi nervorum), which may be involved in back pain. [20][21][22] Sonographic and autopsy studies offered an alternative pathophysiological explanation for acute pain in AMAN: early inflammatory edema, located in the anterior spinal roots at the neural foramina, the ventral rami of spinal nerves or both, could involve abutting dorsal rami, thus causing nerve trunk pain referred to their innervation territories. 23 In our study, monotherapy with gabapentin had a poor analgesic effect for low back pain, indicating nociceptive pain.…”

The evolution and multi-molecular properties of NF1 cutaneous neurofibromas originating from C-fiber sensory endings and terminal Schwann cells at normal sites of sensory terminations in the skin

“…Despite having different timings in their develop and potential to become malignant, an intriguing possibility is that the hyperproliferating SC in pNFs may also be a type of nonmyelinating terminal SC given that both pNFs and cNF have similar histological and functional genomics profiles and both may be derived from BCC lineages. In this case, the SC hyperproliferation in pNFs may involve terminal SC affiliated with arterioles within nerve plexuses that also have innervation, referred to as the nervi nervorum , like that of cutaneous arterioles [36, 118–121].…”

“…The normal expression of GAP-43 among C fibers may be indicative of an ongoing remodeling of their sensory endings and associated terminal glia as part of a normal homeostatic monitoring subliminal maintenance which regularly fluctuates in response to transient tissue stressors, becoming especially exaggerated as part of wound repair [29, 35, 49, 113, 121, 137–141]. As such, the NF1 germinal mutation may compromise the neural/SC cooperativity involved in normal tissue homeostasis.…”

Ultrasound‐Guided Nerve Hydrodissection for Peripheral Entrapment Neuropathies

“…Nerve hydrodissection may exert its effects by releasing pressure on the nervi nervorum and vasa nervorum, which are located outside the epineurium [6,[8][9][10][11][12]. The nervi nervorum regulate the function and discharge of sensory, motor, and mixed nerves.…”

Pain in acute motor axonal neuropathy

“…Although the ventral roots, severely affected in AMAN, predominantly consist of efferent somatic motor fibers, the sheaths of the roots have nociceptive endings (nervi nervorum), which may be involved in back pain. [20][21][22] Sonographic and autopsy studies offered an alternative pathophysiological explanation for acute pain in AMAN: early inflammatory edema, located in the anterior spinal roots at the neural foramina, the ventral rami of spinal nerves or both, could involve abutting dorsal rami, thus causing nerve trunk pain referred to their innervation territories. 23 In our study, monotherapy with gabapentin had a poor analgesic effect for low back pain, indicating nociceptive pain.…”

The evolution and multi-molecular properties of NF1 cutaneous neurofibromas originating from C-fiber sensory endings and terminal Schwann cells at normal sites of sensory terminations in the skin

“…Despite having different timings in their develop and potential to become malignant, an intriguing possibility is that the hyperproliferating SC in pNFs may also be a type of nonmyelinating terminal SC given that both pNFs and cNF have similar histological and functional genomics profiles and both may be derived from BCC lineages. In this case, the SC hyperproliferation in pNFs may involve terminal SC affiliated with arterioles within nerve plexuses that also have innervation, referred to as the nervi nervorum , like that of cutaneous arterioles [36, 118–121].…”

“…The normal expression of GAP-43 among C fibers may be indicative of an ongoing remodeling of their sensory endings and associated terminal glia as part of a normal homeostatic monitoring subliminal maintenance which regularly fluctuates in response to transient tissue stressors, becoming especially exaggerated as part of wound repair [29, 35, 49, 113, 121, 137–141]. As such, the NF1 germinal mutation may compromise the neural/SC cooperativity involved in normal tissue homeostasis.…”

Ultrasound‐Guided Nerve Hydrodissection for Peripheral Entrapment Neuropathies

“…Nerve hydrodissection may exert its effects by releasing pressure on the nervi nervorum and vasa nervorum, which are located outside the epineurium [6,[8][9][10][11][12]. The nervi nervorum regulate the function and discharge of sensory, motor, and mixed nerves.…”