Sinusoidal dilation increases the risk of complications in hepatectomy for CRCLM – Protective effect of bevacizumab and diabetes mellitus, serum gamma-glutamyltranspeptidase as predictive factor

Martins, João Rio; Alexandrino, Henrique; Oliveira, Rui Caetano; Cipriano, Maria Augusta; Falcão, Daniela; Ferreira, L.; Martins, Ricardo; Serôdio, Marco; Martins, Martinho A. S.; Tralhão, José Guilherme; Castro, Lígia; Sousa, F. Castro e

doi:10.1016/j.ejso.2016.02.017

Cited by 14 publications

(13 citation statements)

References 40 publications

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“…Hepatectomies were performed as previously described . Twenty‐two (73%) patients underwent minor hepatectomies (up to two Couinaud segments) and eight (27%) major hepatectomies (three or more Couinaud segments).…”

Section: Methodsmentioning

confidence: 99%

Mitochondrial bioenergetics and posthepatectomy liver dysfunction

Alexandrino

Varela

Martins

et al. 2016

Eur J Clin Investigation

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Section: Methodsmentioning

confidence: 99%

Mitochondrial bioenergetics and posthepatectomy liver dysfunction

Alexandrino

Varela

Martins

et al. 2016

Eur J Clin Investigation

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“…Our department's technique for Hp has been previously described. 28 Major Hp was performed in three (15.8%) patients. The resection was anatomical in ten (52.6%) cases (…”

Section: Operative Proceduresmentioning

confidence: 99%

<p>Prognostic Factors After Hepatectomy for Gastric Adenocarcinoma Liver Metastases: Desmoplastic Growth Pattern as the Key to Improved Overall Survival</p>

Temido

Oliveira

Martins³

et al. 2020

CMAR

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“…After 10 years and many studies, results are still heterogeneous, including patients with different and incomparable chemotherapies, without essential and exhaustive histological analysis. 10,12–17 Our study is interesting as the patients received only one line of chemotherapy, giving us pertinent and homogeneous results on the impact of chemotherapy on liver. The study by Rubbia-Brandt et al 9 did not show any impact of sex, contrary to our results.…”

Section: Discussionmentioning

confidence: 99%

Hepatotoxicities Induced by Neoadjuvant Chemotherapy in Colorectal Cancer Liver Metastases: Distinguishing the True From the False

Desjardin

Bonhomme

Bail

et al. 2019

Clin Med Insights Oncol

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Background:Pre-operative chemotherapy for colorectal liver metastasis (CRLM) is thought to be the cause of hepatotoxicity of non-tumoural parenchyma. Studies on hepatotoxicity are contradictory. We investigated the impact of a single-line pre-operative chemotherapy on non-tumoural liver analysed by an expert hepatico-pancreatico-biliary pathologist, and the consequences on surgical outcomes.Patients and methods:Patients operated for CRLM, after a pure first-line pre-operative chemotherapy, were retrospectively included. Two comparative histopathological analyses were performed for vascular toxicity and steatohepatitis.Results:Between 2003 and 2015, 147 patients were included. Chemotherapy was based on oxaliplatin (40.1%), irinotecan (55.8%), or both (4.1%). The expert pathologist described 38.8% of vascular lesions including dilation, nodular regeneration, and peliosis. In multivariate analysis, vascular lesions correlated to male sex (P = .01), pre-operative platelets <150 g/L (P = .04), and aspartate aminotransferase to platelet ratio index (APRI) score >0.36 (P = .02). Steatohepatitis was observed in 15 patients (10.2%), more frequently after irinotecan (14.8% vs 3.4%, P = .01; odds ratio [OR] = 7.3; 95% confidence interval [CI] = [1.5-34.7]), and for patients with body mass index (BMI) >25 kg/m2 (P = .004; OR = 10.0; 95% CI = [2.1-47.5]). A total of 29 patients (19.7%) developed major complications with 2 risk factors: portal vein obstruction (PVO) and septic surgery. Reproducibility assessment of steatohepatitis and dilated lesions by 2 pathologists showed moderate agreement (Kappa score 0.53 and 0.54, respectively).Conclusions:There is a probable association between non-alcoholic steatohepatitis (NASH) and irinotecan. Oxaliplatin seems to lead to higher vascular lesions. Except in the presence of pre-existent comorbidities, liver toxicities should not restrain the use of pre-operative chemotherapy prior to parenchymal-sparing surgery.

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Sinusoidal dilation increases the risk of complications in hepatectomy for CRCLM – Protective effect of bevacizumab and diabetes mellitus, serum gamma-glutamyltranspeptidase as predictive factor

Cited by 14 publications

References 40 publications

Mitochondrial bioenergetics and posthepatectomy liver dysfunction

Mitochondrial bioenergetics and posthepatectomy liver dysfunction

<p>Prognostic Factors After Hepatectomy for Gastric Adenocarcinoma Liver Metastases: Desmoplastic Growth Pattern as the Key to Improved Overall Survival</p>

Hepatotoxicities Induced by Neoadjuvant Chemotherapy in Colorectal Cancer Liver Metastases: Distinguishing the True From the False

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