Sinonasal Leiomyosarcoma: Review of Literature and Case Report

Feiz-Erfan, Iman; Spetzler, Robert F.; Isaacs, Jeffrey D; Hott, Jonathan S.; Nakaji, Peter; Coons, Stephen W.; Joganic, Edward J; Kresl, John J.; Milligan, John M; Lettieri, Salvatore C.

doi:10.1097/01.mlg.0000183767.97518.09

Cited by 27 publications

(57 citation statements)

References 36 publications

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“…LMS is uncommonly found in the head and neck region and has been estimated to compose only approximately 2% of sinonasal mesenchymal tumors [3]. However, there is an increased risk of LMS occurring as a secondary tumor in patients with a history of treated RB regardless of the history of radiation therapy.…”

Section: Discussionmentioning

confidence: 99%

“…First, there is some degree of anatomic overlap in the primary tumor origin in the craniofacial area, which makes classifying tumors that are purely sinonasal in origin difficult. Table 1 lists 14 reported cases of LMS clearly identified as primarily arising from the sinonasal tract of patients with a history of RB selected in addition to the present case [3,4,[9][10][11][12][13][14]. In the large cohort studies of Kleinerman et al [1] and MacCarthy et al [2] of patients with a history of RB developing secondary malignancy the studies did not specify the location in conjunction with the tumor type and thus patients specifically matching the criteria of sinonasal LMS could not be identified.…”

Section: Discussionmentioning

confidence: 99%

“…Treatment generally consists of radical resection, and chemotherapy and radiation therapy have been used with limited success [3]. Tumors confined to the nasal cavity in which complete excision can be achieved have a high rate of survival [19].…”

Section: Discussionmentioning

confidence: 99%

“…A high number of these tumors arise in the head and neck region. Leiomyosarcomas (LMS) account for a high proportion of these malignancies; however, LMS in the sinonasal region generally are uncommon and are associated with a locally aggressive course and have a poor prognosis [2,3].…”

Section: Introductionmentioning

confidence: 99%

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Nasal Sinus Leiomyosarcoma in a Patient with History of Non-Hereditary Unilateral Treated Retinoblastoma

Fitzpatrick

Woodworth

Monteiro

et al. 2010

Head and Neck Pathol

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Hereditary patients with a history of treated retinoblastoma (RB) have a greatly increased risk of a broad spectrum of secondary malignancies appearing many years later, with a high incidence in the head and neck region. Leiomyosarcomas (LMS) account for up to 58% of these tumors. LMS in the sinonasal region generally are uncommon and are associated with a locally aggressive course and have a poor prognosis. RB may occur in two forms. The hereditary form is generally bilateral but can present unilaterally with a positive family history and typically exhibits a germline mutation in the RB1 gene on chromosome 13. The non-hereditary form is usually unilateral but can show the same germline mutation in up to 10% of cases. Patients with hereditary RB have been shown to have a significantly higher cumulative risk of developing secondary malignancies than those with the non-hereditary form (28 vs. 1.44% respectively). Most reported cases of sinonasal LMS are in patients with a history of the bilateral hereditary form of treated RB. We report a case of LMS of the nasal sinus area in a 35-yearold African American male with a history of non-hereditary unilateral RB and radiation therapy. To the best of our knowledge, this is the first reported case of sinonasal LMS arising in a patient with a history of non-hereditary unilateral RB. The clinical history, radiology, and pathology are presented along with a brief discussion of the literature.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nasal Sinus Leiomyosarcoma in a Patient with History of Non-Hereditary Unilateral Treated Retinoblastoma

Fitzpatrick

Woodworth

Monteiro

et al. 2010

Head and Neck Pathol

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“…Bu tümör tipinin, sinonazal bölgedeki tümörler içindeki insidansı 1.5%-2.1% ile bir hayli düşüktür. LMS tedavisindeki en etkili yöntemin cerrahi olduğu konusunda genel bir kanı bulunmaktadır, tedavi başarısındaki en önemli unsur ise tümörün boyutudur (2). Eskiden LMS tedavisindeki rolleri palyatif olan radyoterapi (RT) ve kemoterapinin (KT) ise yeni tedavi rejimlerinin tanımlanması ile cerrahi sonrası uygulanmaları giderek artmaktadır (3).…”

Section: Introductionunclassified

Nazal kavitenin nadir bir primer tümörü olarak leiyomiyosarkom

Şahi̇n¹,

Göde²,

Midilli³

2015

Ege Tıp Dergisi

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ÖzDüz kas hücrelerinden kaynaklanan, genelde endometrium ve gastrointestinal traktta saptanan leiyomiyosarkom, nadir görülen yumuşak doku tümörlerindendir. Burun ve paranazal kavitenin en sık görülen malignite tipi olan karsinomlara nazaran sarkomların insidansı bir hayli düşüktür ve bu bölgenin sarkomları arasında leiyomiyosarkoma az rastlanmaktadır. Bu tümörlerde genelde tercih edilen tedavi cerrahi rezeksiyondur. Bu yazıda nadir bir yerleşim yeri olarak alt konka posteriorundan kaynaklanmış ve endoskopik transnazal cerrahi rezeksiyon ile tedavi edilmiş bir nazal kavite leiyomiyosarkomu olgusu, literatür bilgileri eşliğinde sunulmaktır.Anahtar Sözcükler: Nazal kavite, leiyomiyosarkom. Abstract Leimyosarcoma is a rare soft tissue tumor originating from smooth muscle cells and it is usually diagnosed in the endometrium and gastrointestinal tract. Compared with carcinomas which are the most common malignancies of the nose and the paranasal cavity, the incidence of sarcomas is quite low and leiomyosarcomas are rarely found among these sarcomas. Surgical excision is the usually preferred treatment choice for these tumors. In this paper, a case with nasal cavity leimyosarcoma originating from a rare location as the posterior part of lower concha and treated with endoscopic transnasal surgical excision is presented with the relevant literature.Keywords: Nasal cavity, leiomyosarcoma. GirişTüm yumuşak doku sarkomlarının yaklaşık 7%sini leiyomisarkomlar (LMS), uterus ve gastrointestinal trakt gibi düz kas dokusundan zengin organlardan, nadiren ekstremiteler ve baş-boyun bölgesi gibi diğer vücut bölgelerinden kaynaklanmaktadırlar. Baş-boyun bölgesi LMS'larının, kan damarlarının tunika mediasından, sirkumvallat papillalardan, tükrük bezi miyoepitelyal hücrelerinden ya da pluripotent mezenkimal hücrelerden kaynaklandıkları düşünülmektedir (1). Bu tümör tipinin, sinonazal bölgedeki tümörler içindeki insidansı 1.5%-2.1% ile bir hayli düşüktür. LMS tedavisindeki en etkili yöntemin cerrahi olduğu konusunda genel bir kanı bulunmaktadır, tedavi başarısındaki en önemli unsur ise tümörün boyutudur (2). Eskiden LMS tedavisindeki rolleri palyatif olan radyoterapi (RT) ve kemoterapinin (KT) ise yeni tedavi rejimlerinin tanımlanması ile cerrahi sonrası uygulanmaları giderek artmaktadır (3). Bu yazıda burun kanaması ve burun tıkanıklığı şikayetleri ile başvuran, muayenesinde saptanan nazal kitlenin LMS olarak belirlenmesi üzerine cerrahi rezeksiyon ve sonrasında RT ile tedavi edilen, 3 yılı aşkın izleminde nüks saptanmayan 57 yaşındaki kadın hasta sunulmaktadır. Olgu Sunumu57 yaşında kadın hasta, bir yıldır ara ara olan burun kanaması ve giderek artan tek taraflı burun tıkanıklığı şikayetleri ile başvurdu. Yapılan fizik muayenesinde endoskopik bakı ile görülebilen sol nazal kavite posteriorunda koanaya geçişi tama yakın engelleyen ağrısız kitle saptandı. Diğer kulak burun boğaz muayeneleri normaldi. Koranal ve aksiyel planlarda elde edilen paranazal bilgisayarlı tomografi (BT) tetkikinde sol nazal kavite posteriorunda bu bölgeyi ve koa...

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