Sinonasal adenoid cystic carcinoma: a population‐based analysis of 694 cases

Unsal, Aykut A.; Chung, Sei Y.; Zhou, Albert H.; Baredes, Soly; Eloy, Jean Anderson

doi:10.1002/alr.21875

Cited by 38 publications

(41 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Common presenting symptoms of SNACC include maxillary pain/pressure, unilateral nasal blockage, and recurrent epistaxis . Consistent with other studies, including large database analyses, this study found that SNACCs most commonly occur within the maxillary sinus (49.7%) followed by the nasal cavity (32.4%) . It is thus important to assess for perineural invasion for all maxillary sinus tumors (eg, cheek numbness) due to the predilection of SNACC to track along the infraorbital nerve.…”

Section: Discussionsupporting

confidence: 86%

“…In our study, 49.1% of patients presented with stage IV disease, further illustrating the possibility of presenting with significant tumor spread. In contrast to other head and neck ACCs, presentation of SNACC with nodal disease and distant metastases was less common (3.6% and 3.7%, respectively), likely due to the scarce lymphatic drainage patterns of the sinonasal tract …”

Section: Discussionmentioning

confidence: 82%

“…An understanding of primary tumor sites, treatment options, and predictors of overall survival is important for timely diagnosis, formation of guidelines of treatment, and understanding prognosis and counseling patients regarding SNACC. The current body of literature analyzing prognostic factors of this rare malignancy is lacking, with only 2 large retrospective studies describing a heterogeneous population . To our knowledge, this is the first study to use the NCDB, a validated population‐based database, to study the demographic, socioeconomic, clinicopathologic, and treatment factors, including treatment sequence, associated with all‐cause mortality.…”

Section: Discussionmentioning

confidence: 99%

“…Due to the rarity of SNACC, the factors influencing survival are not well defined. Database analyses have been carried out using the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database and have shown that surgery greatly improves survival, whereas the role of other therapies remains less clear . In this study, we used the National Cancer Database (NCDB) to analyze overall survival (OS) as it relates to patients’ demographics as well as tumor characteristics and treatments rendered.…”

mentioning

confidence: 99%

“…In this study, we used the National Cancer Database (NCDB) to analyze overall survival (OS) as it relates to patients’ demographics as well as tumor characteristics and treatments rendered. This database analysis builds upon existing single‐institution case reports and population data analyses to add additional cases to the literature and examine the factors, including treatment sequence, associated with all‐cause mortality in patients with SNACC …”

mentioning

confidence: 99%

See 4 more Smart Citations

Adenoid cystic carcinoma of the sinonasal tract: a review of the national cancer database

Trope

Triantafillou

Kohanski

et al. 2019

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

Background: Sinonasal adenoid cystic carcinoma (SNACC) is a rare malignancy with a propensity for distant metastasis. In this study we describe the incidence and determinants of survival among patients with SNACC between the years 2004 and 2012 using the National Cancer Database (NCDB). Methods:This was a retrospective, population-based cohort study performed at a tertiary academic medical center. All participants were diagnosed with SNACC between 2004 and 2012 within the NCDB. The main outcome was overall survival (OS). Results:A total of 793 patients were identified. The cohort was composed of 46.9% males. Mean age at diagnosis was 59.6 years. The maxillary sinus was the most common primary site (49.7%). Nodal disease was seen in 3.6% of the patients, whereas 3.7% had distant metastases. Stage IV disease was seen in 49.1% of cases. In total, 77.4% of patients underwent surgery, 68.2% received radiation therapy, and 16.4% had chemotherapy. Median OS was 78.5 months; OS at 1, 2, and 5 years was 91%, 83%, and 61%, respectively. On multivariate analysis, advanced age (p = 0.001), frontal sinus primary site (p < 0.001), positive margins (p < 0.001), Charlson comorbidity index >0 (p = 0.01), residing in an urban se ing (p = 0.04), poorly differentiated or undifferentiated tumor grade (p = 0.003), and advanced tumor stage (p = 0.01) were associated with worse OS, whereas surgery (p < 0.001), but not radiation therapy (p = 0.52) or chemotherapy (p = 0.57), predicted improved OS. Conclusion:Predictors of survival in SNACC include age, comorbidity status, grade, and stage. Surgery is associated with improved survival and remains the mainstay of therapy, whereas the roles of radiation therapy and chemotherapy require future investigation. C 2019 ARS-AAOA, LLC.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Adenoid cystic carcinoma of the sinonasal tract: a review of the national cancer database

Trope

Triantafillou

Kohanski

et al. 2019

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

show abstract

Editorial

Han¹

2017

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

ICAR: endoscopic skull‐base surgery

Wang

Zanation

Gardner

et al. 2019

Int Forum Allergy Rhinol

Self Cite

151

279

View full text Add to dashboard Cite

Background Endoscopic skull‐base surgery (ESBS) is employed in the management of diverse skull‐base pathologies. Paralleling the increased utilization of ESBS, the literature in this field has expanded rapidly. However, the rarity of these diseases, the inherent challenges of surgical studies, and the continued learning curve in ESBS have resulted in significant variability in the quality of the literature. To consolidate and critically appraise the available literature, experts in skull‐base surgery have produced the International Consensus Statement on Endoscopic Skull‐Base Surgery (ICAR:ESBS). Methods Using previously described methodology, topics spanning the breadth of ESBS were identified and assigned a literature review, evidence‐based review or evidence‐based review with recommendations format. Subsequently, each topic was written and then reviewed by skull‐base surgeons in both neurosurgery and otolaryngology. Following this iterative review process, the ICAR:ESBS document was synthesized and reviewed by all authors for consensus. Results The ICAR:ESBS document addresses the role of ESBS in primary cerebrospinal fluid (CSF) rhinorrhea, intradural tumors, benign skull‐base and orbital pathology, sinonasal malignancies, and clival lesions. Additionally, specific challenges in ESBS including endoscopic reconstruction and complication management were evaluated. Conclusion A critical review of the literature in ESBS demonstrates at least the equivalency of ESBS with alternative approaches in pathologies such as CSF rhinorrhea and pituitary adenoma as well as improved reconstructive techniques in reducing CSF leaks. Evidence‐based recommendations are limited in other pathologies and these significant knowledge gaps call upon the skull‐base community to embrace these opportunities and collaboratively address these shortcomings.

show abstract

Sinonasal adenoid cystic carcinoma: a population‐based analysis of 694 cases

Cited by 38 publications

References 41 publications

Adenoid cystic carcinoma of the sinonasal tract: a review of the national cancer database

Adenoid cystic carcinoma of the sinonasal tract: a review of the national cancer database

Editorial

ICAR: endoscopic skull‐base surgery

Contact Info

Product

Resources

About