Single-photon emission tomography of a computerised model of pulmonary embolism

Magnussen, John; Chicco, Peter; Palmer, Amanda W.; Bush, Vivienne; Mackey, D. W.; Storey, Geoffrey; Magee, Michael; Bautovich, George J.; Wall, Hans Van der

doi:10.1007/s002590050475

Cited by 52 publications

(25 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Embolic defects may not be detected if there is shine-through from underlying lung segments with normal perfusion, thus resulting in an underestimation of the extent of perfusion loss (4). Furthermore, the medial basal segment of the right lower lobe is often not visualized on planar scans (2,5). Added to these factors is the widespread use of probabilistic reporting criteria, and a relatively high indeterminate rate, both of which have caused significant dissatisfaction among referring physicians (6,7).…”

mentioning

confidence: 99%

V/Q Scanning Using SPECT and SPECT/CT

2013

View full text Add to dashboard Cite

Learning Objectives: On successful completion of this activity, participants should be able to describe (1) advantages and shortcomings of planar versus SPECT V/Q scanning, (2) advantages and disadvantages of CT pulmonary angiography versus V/Q SPECT in the investigation of pulmonary embolism, and (3) an overview of image acquisition, processing, display, and reporting of V/Q SPECT studies.Financial Disclosure: The authors of this article have indicated no relevant relationships that could be perceived as a real or apparent conflict of interest. CME Credit: SNMMI is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to sponsor continuing education for physicians. SNMMI designates each JNM continuing education article for a maximum of 2.0 AMA PRA Category 1 Credits. Physicians should claim only credit commensurate with the extent of their participation in the activity. For CE credit, participants can access this activity through the SNMMI Web site (http:// www.snmmi.org/ce_online) through September 2016.Planar ventilation-perfusion ( V/Q) scanning is often used to investigate pulmonary embolism; however, it has well-recognized limitations. SPECT overcomes many of these through its ability to generate 3-dimensional imaging data. V/Q SPECT has higher sensitivity, specificity, and accuracy than planar imaging and a lower indeterminate rate. SPECT allows for new ways to display and analyze data, such as parametric V/Q ratio images. Compared with CT pulmonary angiography, SPECT has higher sensitivity, a lower radiation dose, fewer technically suboptimal studies, and no contrast-related complications. Any nuclear medicine department equipped with a modern hybrid scanner can now perform combined V/Q SPECT with CT (using low-dose protocols) to further enhance diagnostic accuracy. V/Q SPECT (with or without CT) has application in other pulmonary conditions and in research. Si nce its first description by Wagner et al. in 1964 (1), the planar lung scan has been one of the most commonly performed studies in nuclear medicine. It is, however, a test with significant limitations, which have had an adverse impact on its reputation (2,3). Because planar imaging is a 2-dimensional technique, it has inherent limitations, especially related to overlap of anatomic segments. Assigning defects to specific lung segments is often difficult, and the variability in segment size and shape between patients makes accurate determination of the extent of embolic involvement in individual segments a challenge (2). Embolic defects may not be detected if there is shine-through from underlying lung segments with normal perfusion, thus resulting in an underestimation of the extent of perfusion loss (4). Furthermore, the medial basal segment of the right lower lobe is often not visualized on planar scans (2,5). Added to these factors is the widespread use of probabilistic reporting criteria, and a relatively high indeterminate rate, both of which have caused significant dissatisfaction among referring physicians (6,7). ...

show abstract

mentioning

confidence: 99%

V/Q Scanning Using SPECT and SPECT/CT

2013

View full text Add to dashboard Cite

show abstract

“…It has been shown that overlapping structures result in image worsening when planar imaging is used [20,21] and this is particularly true in lung scan where numerous segments are entangled. SPECT enables to get rid of most of the environment when analysing a specific zone and the visual comfort brought by its use is obvious.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of Tomographic Versus Planar Lung Scintigraphy in Suspected Pulmonary Embolism in a Daily Practice

Weinmann¹,

Moretti²,

Brauner³

2008

TOMIJ

View full text Add to dashboard Cite

Abstract:Objectives: Lung scintigraphy is non-diagnostic in most patients suspected of pulmonary embolism when performed in planar mode. Tomographic mode could improve lung scan performance but has not been rigorously assessed. In this study we assessed the usefulness of tomographic mode in patients with a non-diagnostic lung scan scintigraphy.Methods: pulmonary embolism was diagnosed or ruled out in consecutive patients with a non-diagnostic lung scan by the combination of a 4-slices computerized tomography and a lower-limb ultrasonography. Results given by reading the tomographic mode in ventilation/perfusion lung scan were compared to final diagnosis.Results: 142 out of 392 consecutive patients with a non-diagnostic planar lung scintigraphy were included while 47 were excluded, 45 because of contra-indication to contrast medium and 2 because of non-optimal opacification of pulmonary arteries. Ninety-five patients were evaluated. Pulmonary embolism was diagnosed in 20 (21%) patients and ruled out in 75 (79%). Concordance with final diagnosis was found in 77/94 (82%) patients. Tomographic mode was non-diagnostic in 1 (1%) patient. Tomographic mode sensitivity/specificity/accuracy were 0.79/0.83/0.80 respectively. Negative predictive value was 0.94. Discordances were related to single sub segmental or non-occluding segmental thrombus. Conclusion:Tomographic mode is diagnostic in nearly all patients and agreement with final diagnosis is found in the majority. Its excellent negative predictive value enables to rule out pulmonary embolism. Discordances were related to single sub segmental or non-occluding segmental thrombus which prognosis value remains to be established.

show abstract

“…Preliminary evaluation of SPECT imaging applied to ventilatiodperfusion scintigraphy has suggested that it may further improve the accuracy of the scintigraphic diagnosis of PE. 18 The continuing improvement of the various imaging technologies, particularly if faster assessment of the thorax becomes routinely available with helical CT, suggests that further outcomeoriented studies of their application to diagnosis of PE are to be encouraged. It is reasonable to hope that they will ultimately lead to significant further reduction in uncertainties surrounding …”

Section: \mentioning

confidence: 99%