Single photon emission computed tomography using 99Tcm-HMPAO in Alzheimer??s disease

Liu, H. C.; Liu, R. S.; Lin, Ker Neng; Wang, S. J.; Fuh, Jong‐Ling; Yeh, Su‐Ling; Chiang, B.N.

doi:10.1097/00006231-199207000-00009

Cited by 11 publications

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“…It might be argued that CBF findings in both conditions reflect cortical atrophy, given that both patient groups were found to have similar degrees of abnormality revealed by X-ray CT. However, previous studies have shown that 50% of CBF abnormality occurs in X-ray CTnormal brain regions [57] and that CBF SPECT is more sensitive than X-ray CT in revealing the topographical distribution of cortical and subcortical pathology in degenerative brain disease [11,28]. Within the AD group, CBF changes were mirrored by patterns of neuropsychological breakdown indicative of cortical dysfunction: left-right cortical blood flow asymmetry was found to reflect the relative prominence of visuospatial and/or language impairment (Fig.…”

Section: Discussionmentioning

confidence: 99%

A 99m Tc-HMPAO single-photon emission computed tomography study of Lewy body disease

Varma

Talbot

Snowden

et al. 1997

Journal of Neurology

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The purpose of this study was to investigate patterns of 99mTc-HMPAO single-photon emission computed tomography (SPECT) abnormality in Lewy body disease (LBD) and to compare findings with those encountered in Alzheimer's disease (AD). The study group comprised 20 consecutive patient referrals fulfilling clinical criteria for LBD. All patients had fluctuating cognitive impairment and 'subcortical' dysfunction with or without perceptuospatial and/or linguistic impairment. Six patients had asymmetrical signs of parkinsonism (three left-sided and three right-sided), and 14 patients had symmetrical features of extrapyramidal involvement. 99mTc-HMPAO SPECT imaging was performed on LBD patients and findings compared with those of 57 patients with 'probable' AD and 11 normal age-matched controls. Within the LBD and AD groups, patterns of cortical and subcortical blood-flow abnormality were compared with patterns of cognitive and neurological breakdown. LBD was associated with bilateral posterior cortical blood flow abnormality, a pattern strikingly similar to that found in AD. Within the LBD group, cortical blood-flow abnormality was found to reflect patterns of neurological dysfunction (parkinsonism) indicative of subcortical involvement. In contrast, cortical blood-flow changes did not reflect patterns of neuropsychological impairment suggestive of cortical dysfunction. Within the AD group, cortical blood-flow changes were mirrored by the pattern of neuropsychological impairment. Findings support the notion that cortical blood-flow abnormality in LBD might reflect a combination of direct cortical pathology and cortical deafferentation secondary to subcortical Lewy body pathology. It would appear that 99mTc-HMPAO SPECT imaging is of limited value in the clinical differentiation of LBD and AD.

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Section: Discussionmentioning

confidence: 99%

A 99m Tc-HMPAO single-photon emission computed tomography study of Lewy body disease

Varma

Talbot

Snowden

et al. 1997

Journal of Neurology

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“…Eine asymmetrische Atrophie wurde bisher auch vereinzelt bei Fällen von AD beschrieben, die kognitive Defizite bereits im Frühstadium der Erkranl<Ung aufweisen [10]. Liu [25] hat in einer SPECT-Untersuchung von 37 klinisch diagnostizierten AD in 10 Fällen eine bilaterale, jedoch asymmetrische Atrophie gefunden. Er fand dabei eine positive Korrelation dieser SPECT-Veränderungen mit dem präsenilen Beginn der Erl<rankung.…”

Section: Bei Einem Weiteren Patienten (Fall 5) Mit Typisch Präsenilemunclassified

Frontallappen-Demenzen

Zachhuber¹,

Leblhuber²,

Bancher³

et al. 1999

Fortschr Neurol Psychiatr

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Frontal lobe dementia (FLD) is characterised clinically by personality changes and a progressive speech disorder finally leading to mutism. In the course of the disease also other neurological syndromes may occur such as parkinsonism, a partial Klüver-Bucy-syndrome or a degeneration of motoneurons (FLD + MND). The latter leads to death within about three years. The clinical diagnosis of FLD is supported by functional (SPECT) and morphological (CT, MRI) investigations. From 1988 to 1997, 9 cases of FLD (6 female, 3 male) were clinically diagnosed at our department of Gerontology, LNK Linz. In two of these cases the clinical diagnosis was confirmed histopathologically. Characteristically, all except one patients showed a presenile beginning of the disease. The clinical course was slowly progressive with a mean duration of about 10 years. Special attention was given to additional signs and symptoms of motor neuron disease, parkinsonism and hyperorality. Six patients suffered from FLD + MND; parkinsonism (rigid-akinetic type) and a partial Klüver-Bucy-syndrome were diagnosed in 5 cases each. In histopathological investigations the incidence of FLD seems to increase. This type of dementia should be considered as an important diagnosis differential of presenile dementia-syndromes.

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Correlation between Severity of Dementia and Decreased Cerebral Blood Flow in Alzheimer’s Disease and Senile Dementia of the Alzheimer’s Type

Kawabata

Tachibana

Tomino

et al. 1995

Alzheimer’s and Parkinson’s Diseases

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Single photon emission computed tomography using 99Tcm-HMPAO in Alzheimer??s disease

Cited by 11 publications

References 0 publications

A 99m Tc-HMPAO single-photon emission computed tomography study of Lewy body disease

A 99m Tc-HMPAO single-photon emission computed tomography study of Lewy body disease

Frontallappen-Demenzen

Correlation between Severity of Dementia and Decreased Cerebral Blood Flow in Alzheimer’s Disease and Senile Dementia of the Alzheimer’s Type

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