Single-embryo transfer of vitrified-warmed blastocysts yields equivalent live-birth rates and improved neonatal outcomes compared with fresh transfers

Roy, Tammie K.; Bradley, Cara K.; Bowman, Mark; McArthur, Steven J.

doi:10.1016/j.fertnstert.2014.01.046

Cited by 132 publications

(97 citation statements)

References 31 publications

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“…Ovarian stimulation, oocyte retrieval, IVF, ICSI, embryo culture, blastocysts assessment, and fresh blastocyst transfer has been described previously (Roy et al, 2014). Frequent ejaculation patients were instructed to ejaculate every day for 7 days prior to the day of semen collection for insemination.…”

Section: Clinical Proceduresmentioning

confidence: 99%

“…The fertilization rate was calculated as zygotes (2PN embryos) per oocytes inseminated. The good blastocyst rate was calculated as Day 5 grade I or grade II expanding blastocysts, hatching blastocysts, or fully hatched blastocysts per zygotes minus any embryos utilized prior to Day 5; the definition of grade I and grade II blastocysts have been reported previously (Roy et al, 2014). The utilization rate was calculated as embryos transferred or cryopreserved per zygotes.…”

Section: Outcomes Measuredmentioning

confidence: 99%

See 1 more Smart Citation

Intervention improves assisted conception intracytoplasmic sperm injection outcomes for patients with high levels of sperm DNA fragmentation: a retrospective analysis

Bradley¹,

McArthur²,

Gee³

et al. 2016

Andrology

104

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SUMMARYSperm DNA fragmentation (SDF) is used in assisted reproductive technology (ART) programs as an indicator for sperm quality, although there is still a lack of consensus as to its clinical utility. In this retrospective study, we examined intracytoplasmic sperm injection (ICSI) outcomes of 1924 infertile patients who underwent SDF analysis using the sperm chromatin integrity test. ART patients were classified as having low [DNA fragmentation index (DFI) <29%] or high SDF (DFI ≥29%) and by whether or not an intervention [physiological intracytoplasmic sperm injection (PICSI), intracytoplasmic morphologically selected sperm injection (IMSI), testicular sperm extraction (TESE)/testicular sperm aspiration (TESA), frequent ejaculation] was performed. High SDF patients who did not have an intervention had a lower fertilization rate and poorer clinical outcomes from blastocyst transfers as compared with low SDF patients; the fertilization rate was 66.0% vs. 70.2% (p = 0.042), single embryo transfer (SET) fetal heart pregnancy rate was 28.5% vs. 45.2% (p = 0.042), and SET live birth rate was 24.9% vs. 40.6% (p = 0.060), respectively. Furthermore, high SDF patients who had an intervention had significantly improved blastocyst transfer outcomes, similar to those of low SDF patients; the SET live birth rate for high SDF intervention patients was 43.8% as compared with 24.9% for high SDF no intervention patients (p = 0.037) and 40.6% for low SDF patients (p = 0.446). Analysis of the three main intervention subgroups for high SDF patients revealed that TESE/TESA patients had the highest SET live birth rate; in comparison with 24.2% for high SDF patients who did not have an intervention, PICSI patients had 38.3% (p = 0.151), IMSI patients had 28.7% (p = 0.680), and TESE/TESA patients had 49.8% (p = 0.020). Our data suggest that SDF results indicate ICSI outcomes and that patients who have high SDF benefit from an intervention.

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Section: Clinical Proceduresmentioning

confidence: 99%

Section: Outcomes Measuredmentioning

confidence: 99%

Intervention improves assisted conception intracytoplasmic sperm injection outcomes for patients with high levels of sperm DNA fragmentation: a retrospective analysis

Bradley¹,

McArthur²,

Gee³

et al. 2016

Andrology

104

View full text Add to dashboard Cite

show abstract

“…One limitation of our study is that after devitrification, no culture to blastocyst was performed, although this has been shown to improve pregnancy rates in cryotransfer programmes [26,27]. In a future study, it would be useful to investigate the efficacy of sequential elective single frozen blastocyst transfer compared with cleavage stage embryo transfer.…”

Section: Nsmentioning

confidence: 99%

Cumulative live birth rate after two single frozen embryo transfers (eSFET) versus a double frozen embryo transfer (DFET) with cleavage stage embryos: a retrospective cohort study

Regalado

Clavero

Gonzálvo

et al. 2014

J Assist Reprod Genet

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Purpose According to the latest ART report for Europe, about 13 % of pregnancies after frozen embryo transfer are multiple. Our objective was to analyse the impact on the multiple pregnancy rate of two eSFET (elective single frozen embryo transfers) versus a DFET (double frozen embryo transfer) in women aged under 38 years, who had not achieved pregnancy in their fresh transfer and who had at least two vitrified embryos of A/B quality. Methods This study was conducted from January 2010 to June 2013 at a public hospital. The couples were divided into three groups. Group DFET: the first cryotransfer of two embryos (105 women); cSFET group: the only cryotransfer of a single vitrified embryo (60 women); eSFET group, individually vitrified embryos: 20 patients included in a clinical trial of single-embryo fresh and frozen transfer and 21 patients who chose to receive eSFET. Results The clinical pregnancy rate was 38.1 % in the DET group and the cumulative clinical pregnancy rate was 43.3 % in the eSFET group. There were no significant differences between the DFET and eSFET groups (30.0 vs 34.1 %) in cumulative live birth delivery rate. The rate of multiple pregnancies varied significantly between the DFET and eSFET groups (32.5 vs 0 %, p<0.05). Conclusions For good-prognosis women aged under 38 years, taking embryo quality as a criterion for inclusion, an eSFET policy can be applied, achieving acceptable cumulative clinical pregnancy and live birth rates and reducing multiple pregnancy rates.

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“…Bir diğer gözlemsel çalışmanın sonucuna göre, tek-DET ile taze sikluslara göre hem gebelik haftası hem de doğum ağırlığı daha fazla saptanmıştır. 19 Ancak hipertansif komplikasyonlar DET sonucu daha sık izlenmiş, majör konjenital malformasyonlar açısından taze siklus bebekleri ile belirgin farklılık izlenmemiştir (%2,6 vs %2,8-OR:0,9). Taze embriyo transferi ve DET sikluslarından elde edilen tekil gebeliklerin ele alındığı ve toplam 11 gözlem-sel çalışmanın derlendiği meta analiz sonucuna göre PTD, SGA, LBW parametreleri, DET bebeklerinde daha az saptanmıştır.…”

Section: Taze Ve Dondurulmuş Embri̇yo Transferi̇ Si̇kluslarinin Obstetri̇unclassified

Fresh vs Frozen Embryo Transfer

Pabuçcu¹,

Pabuçcu²

2017

TJRMS

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Single-embryo transfer of vitrified-warmed blastocysts yields equivalent live-birth rates and improved neonatal outcomes compared with fresh transfers

Cited by 132 publications

References 31 publications

Intervention improves assisted conception intracytoplasmic sperm injection outcomes for patients with high levels of sperm DNA fragmentation: a retrospective analysis

Intervention improves assisted conception intracytoplasmic sperm injection outcomes for patients with high levels of sperm DNA fragmentation: a retrospective analysis

Cumulative live birth rate after two single frozen embryo transfers (eSFET) versus a double frozen embryo transfer (DFET) with cleavage stage embryos: a retrospective cohort study

Fresh vs Frozen Embryo Transfer

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