Single dose oral paracetamol (acetaminophen) for postoperative pain

Abstract

Single doses of paracetamol are effective analgesics for acute postoperative pain and give rise to few adverse effects.

Perioperative analgesia for patients undergoing endoscopic sinus surgery: an evidence‐based review

“…Numerous analyses in other specialties have demonstrated the utility of acetaminophen for postoperative analgesia in an attempt to limit unnecessary opioid prescription, leading to the American Pain Society's guidelines endorsing several medications, including acetaminophen, for use in postoperative regimens . In the present analysis, the 4 RCTs evaluating acetaminophen suggested a preponderance of benefit over harm (Table ).…”

Perioperative analgesia for patients undergoing endoscopic sinus surgery: an evidence‐based review

“…Numerous analyses in other specialties have demonstrated the utility of acetaminophen for postoperative analgesia in an attempt to limit unnecessary opioid prescription, leading to the American Pain Society's guidelines endorsing several medications, including acetaminophen, for use in postoperative regimens . In the present analysis, the 4 RCTs evaluating acetaminophen suggested a preponderance of benefit over harm (Table ).…”

Dose Can Help to Achieve Effective Pain Relief for Acute Mild to Moderate Pain with Over-the-Counter Paracetamol

“…Similar findings, with no clear dose-response relationship for NNT after low and high doses of paracetamol, came from a Cochrane review of single dose paracetamol trials in postoperative pain [22], while a review of data by the US Food and Drug Administration (FDA) [23,24] gave an NNT of 3.7 for 1000mg paracetamol and 5.4 for lower doses of 600/650mg paracetamol. A Cochrane review of randomised trials of paracetamol in acute treatment of frequent episodic tension-type headache in adults showed greater pain relief with higher dose paracetamol.…”

Single dose oral paracetamol (acetaminophen) for postoperative pain in adults

“…This updated review included 561 participants treated with a single dose of paracetamol 500 mg and 1886 participants treated with 600 to 650 mg, both unchanged form the previous review. For the 975 to 1000 mg dose, 3252 participants were treated, 495 more than the earlier review (Barden 2004a) giving a more robust (Moore 1998a), but almost identical result.…”

Perioperative analgesia for patients undergoing endoscopic sinus surgery: an evidence‐based review

“…Numerous analyses in other specialties have demonstrated the utility of acetaminophen for postoperative analgesia in an attempt to limit unnecessary opioid prescription, leading to the American Pain Society's guidelines endorsing several medications, including acetaminophen, for use in postoperative regimens . In the present analysis, the 4 RCTs evaluating acetaminophen suggested a preponderance of benefit over harm (Table ).…”

Dose Can Help to Achieve Effective Pain Relief for Acute Mild to Moderate Pain with Over-the-Counter Paracetamol

“…Similar findings, with no clear dose-response relationship for NNT after low and high doses of paracetamol, came from a Cochrane review of single dose paracetamol trials in postoperative pain [22], while a review of data by the US Food and Drug Administration (FDA) [23,24] gave an NNT of 3.7 for 1000mg paracetamol and 5.4 for lower doses of 600/650mg paracetamol. A Cochrane review of randomised trials of paracetamol in acute treatment of frequent episodic tension-type headache in adults showed greater pain relief with higher dose paracetamol.…”

Single dose oral paracetamol (acetaminophen) for postoperative pain in adults

“…This updated review included 561 participants treated with a single dose of paracetamol 500 mg and 1886 participants treated with 600 to 650 mg, both unchanged form the previous review. For the 975 to 1000 mg dose, 3252 participants were treated, 495 more than the earlier review (Barden 2004a) giving a more robust (Moore 1998a), but almost identical result.…”

Perioperative analgesia for patients undergoing endoscopic sinus surgery: an evidence‐based review

“…Numerous analyses in other specialties have demonstrated the utility of acetaminophen for postoperative analgesia in an attempt to limit unnecessary opioid prescription, leading to the American Pain Society's guidelines endorsing several medications, including acetaminophen, for use in postoperative regimens . In the present analysis, the 4 RCTs evaluating acetaminophen suggested a preponderance of benefit over harm (Table ).…”

Dose Can Help to Achieve Effective Pain Relief for Acute Mild to Moderate Pain with Over-the-Counter Paracetamol

“…Similar findings, with no clear dose-response relationship for NNT after low and high doses of paracetamol, came from a Cochrane review of single dose paracetamol trials in postoperative pain [22], while a review of data by the US Food and Drug Administration (FDA) [23,24] gave an NNT of 3.7 for 1000mg paracetamol and 5.4 for lower doses of 600/650mg paracetamol. A Cochrane review of randomised trials of paracetamol in acute treatment of frequent episodic tension-type headache in adults showed greater pain relief with higher dose paracetamol.…”

Single dose oral paracetamol (acetaminophen) for postoperative pain in adults

“…This updated review included 561 participants treated with a single dose of paracetamol 500 mg and 1886 participants treated with 600 to 650 mg, both unchanged form the previous review. For the 975 to 1000 mg dose, 3252 participants were treated, 495 more than the earlier review (Barden 2004a) giving a more robust (Moore 1998a), but almost identical result.…”