Single dose oral fenbufen for acute postoperative pain in adults

Abstract

Background-Fenbufen is a non-selective non-steroidal anti-inflammatory drug (NSAID), used to treat acute and chronic painful conditions. There is no known systematic review of its use in acute postoperative pain.

The scientific evidence for acute pain treatment

“…As a result, updated NNTs are available for some analgesics used for postoperative pain. Additional data for ibuprofen [24], diclofenac [25] and naproxen [26] confirmed NNTs in the range of 2-3.5, suggesting effective analgesia; the lack of evidence for some other nonsteroidal anti-inflammatory drug (NSAID) preparations suggests alternatives should be used [27][28][29].…”

The scientific evidence for acute pain treatment

“…As a result, updated NNTs are available for some analgesics used for postoperative pain. Additional data for ibuprofen [24], diclofenac [25] and naproxen [26] confirmed NNTs in the range of 2-3.5, suggesting effective analgesia; the lack of evidence for some other nonsteroidal anti-inflammatory drug (NSAID) preparations suggests alternatives should be used [27][28][29].…”

Screening for Polymorphism, Cyclodextrin Complexation, and Co-Crystallization of the Non-Steroidal Anti-Inflammatory Drug Fenbufen: Isolation and Characterization of a Co-Crystal and an Ionic Co-Crystal of the API with a Common Coformer

“…Fenbufen (hereinafter FBF) is a well-established NSAID. It acts as a prodrug whose major metabolite, 4-biphenylacetic acid, is a potent, non-selective inhibitor of the enzyme cyclooxygenase (COX-1 and COX-2), thereby preventing the synthesis of prostaglandins which cause inflammation [ 24 , 25 ]. The analgesic and antipyretic effects of FBF are used to treat patients with osteoarthritis, rheumatoid arthritis, tendinitis, ankylosing spondylitis, and post-operative pain [ 25 ].…”

Contemporary uses of old folks: the immunomodulatory and toxic potential of fenbufen

“…It is quickly absorbed in the blood and the highest level is gained within 70 min with 99% protein binding capacity. The plasma half-life of fenbufen and its metabolites is almost 10 to 17 h and is mostly eliminated as urinary conjugates (6). The unique pharmacological profile of fenbufen is responsible for its lower risk to gastrointestinal side effects in patients as compared to other NSAIDs (7).…”

The scientific evidence for acute pain treatment

“…As a result, updated NNTs are available for some analgesics used for postoperative pain. Additional data for ibuprofen [24], diclofenac [25] and naproxen [26] confirmed NNTs in the range of 2-3.5, suggesting effective analgesia; the lack of evidence for some other nonsteroidal anti-inflammatory drug (NSAID) preparations suggests alternatives should be used [27][28][29].…”

Screening for Polymorphism, Cyclodextrin Complexation, and Co-Crystallization of the Non-Steroidal Anti-Inflammatory Drug Fenbufen: Isolation and Characterization of a Co-Crystal and an Ionic Co-Crystal of the API with a Common Coformer

“…Fenbufen (hereinafter FBF) is a well-established NSAID. It acts as a prodrug whose major metabolite, 4-biphenylacetic acid, is a potent, non-selective inhibitor of the enzyme cyclooxygenase (COX-1 and COX-2), thereby preventing the synthesis of prostaglandins which cause inflammation [ 24 , 25 ]. The analgesic and antipyretic effects of FBF are used to treat patients with osteoarthritis, rheumatoid arthritis, tendinitis, ankylosing spondylitis, and post-operative pain [ 25 ].…”

Contemporary uses of old folks: the immunomodulatory and toxic potential of fenbufen

“…It is quickly absorbed in the blood and the highest level is gained within 70 min with 99% protein binding capacity. The plasma half-life of fenbufen and its metabolites is almost 10 to 17 h and is mostly eliminated as urinary conjugates (6). The unique pharmacological profile of fenbufen is responsible for its lower risk to gastrointestinal side effects in patients as compared to other NSAIDs (7).…”

The scientific evidence for acute pain treatment

“…As a result, updated NNTs are available for some analgesics used for postoperative pain. Additional data for ibuprofen [24], diclofenac [25] and naproxen [26] confirmed NNTs in the range of 2-3.5, suggesting effective analgesia; the lack of evidence for some other nonsteroidal anti-inflammatory drug (NSAID) preparations suggests alternatives should be used [27][28][29].…”

Screening for Polymorphism, Cyclodextrin Complexation, and Co-Crystallization of the Non-Steroidal Anti-Inflammatory Drug Fenbufen: Isolation and Characterization of a Co-Crystal and an Ionic Co-Crystal of the API with a Common Coformer

“…Fenbufen (hereinafter FBF) is a well-established NSAID. It acts as a prodrug whose major metabolite, 4-biphenylacetic acid, is a potent, non-selective inhibitor of the enzyme cyclooxygenase (COX-1 and COX-2), thereby preventing the synthesis of prostaglandins which cause inflammation [ 24 , 25 ]. The analgesic and antipyretic effects of FBF are used to treat patients with osteoarthritis, rheumatoid arthritis, tendinitis, ankylosing spondylitis, and post-operative pain [ 25 ].…”

Contemporary uses of old folks: the immunomodulatory and toxic potential of fenbufen

“…It is quickly absorbed in the blood and the highest level is gained within 70 min with 99% protein binding capacity. The plasma half-life of fenbufen and its metabolites is almost 10 to 17 h and is mostly eliminated as urinary conjugates (6). The unique pharmacological profile of fenbufen is responsible for its lower risk to gastrointestinal side effects in patients as compared to other NSAIDs (7).…”