Single dose oral etoricoxib for acute postoperative pain in adults

Abstract

Single dose oral etoricoxib produces high levels of good quality pain relief after surgery. The 120 mg dose is as effective as, or better than, other commonly used analgesics.

Reducing the Pain: A Systematic Review of Postdischarge Analgesia Following Elective Orthopedic Surgery

“…COX‐2 inhibitors are effective analgesic agents following lower limb orthopedic surgery. This finding supports previous evidence established in single‐dose studies [54,55]. Moreover, the included studies demonstrate a favorable side‐effect profile for COX‐2 inhibitors.…”

Reducing the Pain: A Systematic Review of Postdischarge Analgesia Following Elective Orthopedic Surgery

“…COX‐2 inhibitors are effective analgesic agents following lower limb orthopedic surgery. This finding supports previous evidence established in single‐dose studies [54,55]. Moreover, the included studies demonstrate a favorable side‐effect profile for COX‐2 inhibitors.…”

Defined Daily Dose and Appropriateness of Clinical Application: The Coxibs and Traditional Nonsteroidal Anti-Inflammatory Drugs for Postoperative Orthopaedics Pain Control in a Private Hospital in Malaysia

“…However, there were no adverse effects related to etoricoxib reported in this study. This finding can be confirmed with the systematic review that concluded the safety profile of etoricoxib and its effectiveness to be utilized for managing postoperative pain [ 34 , 35 , 36 ]. In this study, 60 mg, 90 mg, or 120 mg etoricoxib dose once daily was noted in the database, which are compliant with the guidelines (MIMS Malaysia).…”

Analgesic Efficacy of Etoricoxib following Third Molar Surgery: A Meta-analysis

“…Aldington et al [ 46 ] found limited clinical evidence of increased cardiovascular risk in patients who took etoricoxib versus placebo. Moreover, the pooled evaluations of adverse reactions from Clarke et al [ 47 – 49 ] showed a similar risk between etoricoxib and placebo. Baraf et al [ 50 ] assessed the risk of adverse effects of etoricoxib and diclofenac, and the findings showed that etoricoxib had better gastrointestinal tolerability when compared to diclofenac in patients with osteoarthritis.…”

Reducing the Pain: A Systematic Review of Postdischarge Analgesia Following Elective Orthopedic Surgery

“…COX‐2 inhibitors are effective analgesic agents following lower limb orthopedic surgery. This finding supports previous evidence established in single‐dose studies [54,55]. Moreover, the included studies demonstrate a favorable side‐effect profile for COX‐2 inhibitors.…”

Defined Daily Dose and Appropriateness of Clinical Application: The Coxibs and Traditional Nonsteroidal Anti-Inflammatory Drugs for Postoperative Orthopaedics Pain Control in a Private Hospital in Malaysia

“…However, there were no adverse effects related to etoricoxib reported in this study. This finding can be confirmed with the systematic review that concluded the safety profile of etoricoxib and its effectiveness to be utilized for managing postoperative pain [ 34 , 35 , 36 ]. In this study, 60 mg, 90 mg, or 120 mg etoricoxib dose once daily was noted in the database, which are compliant with the guidelines (MIMS Malaysia).…”

Analgesic Efficacy of Etoricoxib following Third Molar Surgery: A Meta-analysis

“…Aldington et al [ 46 ] found limited clinical evidence of increased cardiovascular risk in patients who took etoricoxib versus placebo. Moreover, the pooled evaluations of adverse reactions from Clarke et al [ 47 – 49 ] showed a similar risk between etoricoxib and placebo. Baraf et al [ 50 ] assessed the risk of adverse effects of etoricoxib and diclofenac, and the findings showed that etoricoxib had better gastrointestinal tolerability when compared to diclofenac in patients with osteoarthritis.…”

Reducing the Pain: A Systematic Review of Postdischarge Analgesia Following Elective Orthopedic Surgery

“…COX‐2 inhibitors are effective analgesic agents following lower limb orthopedic surgery. This finding supports previous evidence established in single‐dose studies [54,55]. Moreover, the included studies demonstrate a favorable side‐effect profile for COX‐2 inhibitors.…”

Defined Daily Dose and Appropriateness of Clinical Application: The Coxibs and Traditional Nonsteroidal Anti-Inflammatory Drugs for Postoperative Orthopaedics Pain Control in a Private Hospital in Malaysia

“…However, there were no adverse effects related to etoricoxib reported in this study. This finding can be confirmed with the systematic review that concluded the safety profile of etoricoxib and its effectiveness to be utilized for managing postoperative pain [ 34 , 35 , 36 ]. In this study, 60 mg, 90 mg, or 120 mg etoricoxib dose once daily was noted in the database, which are compliant with the guidelines (MIMS Malaysia).…”

Analgesic Efficacy of Etoricoxib following Third Molar Surgery: A Meta-analysis

“…Aldington et al [ 46 ] found limited clinical evidence of increased cardiovascular risk in patients who took etoricoxib versus placebo. Moreover, the pooled evaluations of adverse reactions from Clarke et al [ 47 – 49 ] showed a similar risk between etoricoxib and placebo. Baraf et al [ 50 ] assessed the risk of adverse effects of etoricoxib and diclofenac, and the findings showed that etoricoxib had better gastrointestinal tolerability when compared to diclofenac in patients with osteoarthritis.…”