Single dose oral analgesics for acute postoperative pain in adults - an overview of Cochrane reviews

Abstract

Single dose oral analgesics for acute postoperative pain in adults -an overview of Cochrane reviews (Review)

Early versus Delayed Mobilization for Arthroscopic Rotator Cuff Repair: a Meta-analysis of Randomized Controlled Trials

“…Besides, recent surgical techniques have shown better results in reducing pain after surgeries [50][51][52] and postoperative multimodal analgesics has been effective. [53] Therefore, most studies showed no statistically signi cant differences in VAS between two protocols at nal follow-up, which is consistent with our report.…”

Early versus Delayed Mobilization for Arthroscopic Rotator Cuff Repair: a Meta-analysis of Randomized Controlled Trials

“…Besides, recent surgical techniques have shown better results in reducing pain after surgeries [50][51][52] and postoperative multimodal analgesics has been effective. [53] Therefore, most studies showed no statistically signi cant differences in VAS between two protocols at nal follow-up, which is consistent with our report.…”

Comparing the Efficacy of Intravenous Morphine versus Ibuprofen or its Compound in Patients with Closed Limb Fractures

“…In contrast, ibuprofen and acetaminophen have longer periods of action than morphine, which is consistent with our result (30,31). Additionally, several studies have shown that the combination of acetaminophen with ibuprofen has a synergistic effect that is greater than the prescription of each drug alone in post-operative patients, which may be due to different analgesic pathways (32)(33)(34).…”

Postoperative pain management using an intravenous combination of ibuprofen and acetaminophen compared with acetaminophen alone after thyroidectomy: A prospective randomized controlled trial

“…28 In Cochrane reviews with the primary outcome being the number of participants who experienced ≥50% pain relief over 4-6 h compared to that of patients receiving placebo or monotherapy, the oral combination of ibuprofen and paracetamol reduced pain better than single drug alone and was less likely to cause side effects. 29,30 Among the various dosages, the RCTs included in these reviews demonstrated that ibuprofen 400 mg/acetaminophen 1000 mg were the most effective, [31][32][33] which was similar to the findings of our study. However, our study differed from the previous RCTs, which focused on the patients undergoing dental surgery (molar extraction) and administered the study drug following pain occurrence.…”

Early versus Delayed Mobilization for Arthroscopic Rotator Cuff Repair: a Meta-analysis of Randomized Controlled Trials

“…Besides, recent surgical techniques have shown better results in reducing pain after surgeries [50][51][52] and postoperative multimodal analgesics has been effective. [53] Therefore, most studies showed no statistically signi cant differences in VAS between two protocols at nal follow-up, which is consistent with our report.…”

Comparing the Efficacy of Intravenous Morphine versus Ibuprofen or its Compound in Patients with Closed Limb Fractures

“…In contrast, ibuprofen and acetaminophen have longer periods of action than morphine, which is consistent with our result (30,31). Additionally, several studies have shown that the combination of acetaminophen with ibuprofen has a synergistic effect that is greater than the prescription of each drug alone in post-operative patients, which may be due to different analgesic pathways (32)(33)(34).…”

Postoperative pain management using an intravenous combination of ibuprofen and acetaminophen compared with acetaminophen alone after thyroidectomy: A prospective randomized controlled trial

“…28 In Cochrane reviews with the primary outcome being the number of participants who experienced ≥50% pain relief over 4-6 h compared to that of patients receiving placebo or monotherapy, the oral combination of ibuprofen and paracetamol reduced pain better than single drug alone and was less likely to cause side effects. 29,30 Among the various dosages, the RCTs included in these reviews demonstrated that ibuprofen 400 mg/acetaminophen 1000 mg were the most effective, [31][32][33] which was similar to the findings of our study. However, our study differed from the previous RCTs, which focused on the patients undergoing dental surgery (molar extraction) and administered the study drug following pain occurrence.…”

Early versus Delayed Mobilization for Arthroscopic Rotator Cuff Repair: a Meta-analysis of Randomized Controlled Trials

“…Besides, recent surgical techniques have shown better results in reducing pain after surgeries [50][51][52] and postoperative multimodal analgesics has been effective. [53] Therefore, most studies showed no statistically signi cant differences in VAS between two protocols at nal follow-up, which is consistent with our report.…”

Comparing the Efficacy of Intravenous Morphine versus Ibuprofen or its Compound in Patients with Closed Limb Fractures

“…In contrast, ibuprofen and acetaminophen have longer periods of action than morphine, which is consistent with our result (30,31). Additionally, several studies have shown that the combination of acetaminophen with ibuprofen has a synergistic effect that is greater than the prescription of each drug alone in post-operative patients, which may be due to different analgesic pathways (32)(33)(34).…”

Postoperative pain management using an intravenous combination of ibuprofen and acetaminophen compared with acetaminophen alone after thyroidectomy: A prospective randomized controlled trial

“…28 In Cochrane reviews with the primary outcome being the number of participants who experienced ≥50% pain relief over 4-6 h compared to that of patients receiving placebo or monotherapy, the oral combination of ibuprofen and paracetamol reduced pain better than single drug alone and was less likely to cause side effects. 29,30 Among the various dosages, the RCTs included in these reviews demonstrated that ibuprofen 400 mg/acetaminophen 1000 mg were the most effective, [31][32][33] which was similar to the findings of our study. However, our study differed from the previous RCTs, which focused on the patients undergoing dental surgery (molar extraction) and administered the study drug following pain occurrence.…”