Single‐dose local administration of teriparatide with a octacalcium phosphate collagen composite enhances bone regeneration in a rodent critical‐sized calvarial defect

Kajii, Fumihiko; Iwai, Atsushi; Tanaka, Hidenori; Matsui, Kosuke; Kawai, Tadashi; Kamakura, Shinji

doi:10.1002/jbm.b.33993

Cited by 21 publications

(27 citation statements)

References 31 publications

(76 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, this study demonstrated that bone regeneration was enhanced more with OCPcolTPTDf than with OCPcol. There could be a similar synergistic effect of OCPcol impregnated with TPTD, as reported recently (Kajii et al, ). However, bone regeneration with β‐TCPcolTPTDf showed no significant differences compared with β‐TCPcol, suggesting that there may be no synergistic effect of β‐TCPcol and TPTD.…”

Section: Discussionsupporting

confidence: 81%

“…In this study, it was confirmed that an OCPcol and TPTD composite (OCPcolTPTDf) could enhance bone regeneration as well as OCPcol with the single local administration of TPTD (OCPcolTPTDd) (Kajii et al, ), and these two materials significantly enhanced bone regeneration more than OCPcol alone. Compared with OCPcolTPTDd, OCPcolTPTDf has several advantages.…”

Section: Discussionmentioning

confidence: 56%

“…In this study, no significant difference was observed between bone regeneration with OCPcolTPTDf 1.0 and that with OCPcolTPTDf 0.1 as well as bone regeneration with OCPcol with the local single administration of TPTD solution (1.0 or 0.1 µg) (Kajii et al, ). It could be considered that OCPcol combined with TPTD could not enhance bone regeneration in a dose‐dependent manner.…”

Section: Discussionmentioning

confidence: 76%

“…At 4 and 12 weeks after implantation, examination of rat calvarium was made using an in vivo micro‐CT system (Latheta LCT‐200; Hitachi Aloka Medical, Tokyo, Japan) during intraperitoneal injection of sodium pentobarbital (50 mg/kg) (Kajii et al, ). After measuring body weight, the treated defects were scanned in 120 µm thickness for slices and 60 µm pixel size.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, it was reported that the local single administration of TPTD (20 µg) with a collagen sponge is effective for repair of a rat calvarial defect (Auersvald et al, ). It was revealed that OCPcol with a local single administration of TPTD (1 or 0.1 µg) which is a low dosage similar to that for the treatment for osteoporosis, enhanced bone repair of the critical‐sized bone defect (Kajii et al, ), and its modality might be practical for improving effective bone regeneration safely. However, it would be more versatile as a medical material if a freeze‐dried composite with OCPcol and TPTD (OCPcolTPTDf) was created.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Bone regeneration by freeze‐dried composite of octacalcium phosphate collagen and teriparatide

et al. 2018

Self Cite

View full text Add to dashboard Cite

Objective Octacalcium phosphate (OCP) and collagen (col) composite (OCPcol) demonstrated superior bone regeneration properties, and its commercialization appears to be forthcoming. As a practical medical material for new combination products, we developed a freeze‐dried composite with OCPcol and teriparatide (TPTD) (OCPcolTPTDf), and investigated its bone regenerative properties. Materials and Methods A disk of OCPcol was made by mixing OCP granules and atelocollagen for medical use. Then, OCPcolTPTDf was prepared by impregnation of the OCPcol disk with 1.0 or 0.1 µg of TPTD solution (OCPcolTPTDf 1.0 and OCPcolTPTDf 0.1, respectively) followed by lyophilization. In vitro release profiles of TPTD from OCPcolTPTDf were determined using an enzyme‐linked immunosorbent assay. Implantation of OCPcolTPTDf or OCPcol was carried out for a rat critical‐sized calvarial defect. And five defects in each group were collected after 12 weeks of implantation. Results The retention–release profiles of TPTD from OCPcolTPTDf supported a higher degree of retention of TPTD. Radiographic, histological, and histomorphometric examinations indicated that regenerated bone was filled in most of the defects of the OCPcolTPTDf. Additionally, the OCPcolTPTDf groups showed significantly enhanced bone regeneration compared with the OCPcol group. Conclusions These results suggested that this newly developed bone regenerative composite could be a practical medical material.

show abstract

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 76%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Bone regeneration by freeze‐dried composite of octacalcium phosphate collagen and teriparatide

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

Bone augmentation by octacalcium phosphate and collagen composite coated with poly‐lactic acid cage

Yanagisawa

Yasuda

Makkonen

et al. 2020

Clinical & Exp Dental Res

Self Cite

View full text Add to dashboard Cite

Objective Although octacalcium phosphate and collagen composite (OCP/Col) has demonstrated excellent bone regeneration, it has never achieved bone augmentation. The present study investigated whether it could be enabled by OCP/Col disks treated with parathyroid hormone (PTH) and covered with a poly‐lactic acid (PLA) cage. Materials and methods The prepared OCP/Col disks with three different types of PLA cages (no hole, one large hole, several small holes) were implanted into subperiosteal pockets in rodent calvaria. Histological, and histomorphometric analyses were conducted at 12 weeks after implantation. Results Implants with all PLA cage variants achieved sufficient bone augmentation, and analyses showed that new bone was formed from the original bone and along the PLA cage. While the PLA cage variant with no holes sporadically evoked new bone formation even at the central area of the roof of the PLA cage, the PLA cage variants with holes had no new bone in the area of the hole or beneath the periosteum. Conclusions These results suggest that sufficient bone augmentation could be achieved by treating the OCP/Col disks with PTH and covering them with a PLA cage, and periosteum might not have been involved in the bone formation in this experiment.

show abstract

Influence of pre‐freezing conditions of octacalcium phosphate and collagen composite for reproducible appositional bone formation

et al. 2020

Self Cite

View full text Add to dashboard Cite

Even though conventionally prepared octacalcium phosphate and collagen composite (OCP/Col) has exhibited excellent bone regeneration and has recently been commercialized for treating bone defects, reproducible appositional bone formation with OCP/Col has never been achieved. The present study investigated whether appositional bone formation could be achieved by altering the density of OCP/Col and applying liquid nitrogen during the preparation of OCP/Col. The prepared OCP/Col disks had eight variations and were divided into categories according to four different type of densities (1.0, 1.3, 1.7, and 2.0) of OCP/Col and two different pre‐freezing conditions of gas phase (G group: −80°C) and liquid phase (L group: −196°C). These disks were implanted into subperiosteal pockets in rodent calvaria, five samples per each eight variations. Radiomorphometric analysis was conducted at 4 and 12 weeks after implantation, and histological analysis was conducted at 12 weeks after implantation. OCP/Col samples in the L group tended to retain their height and shape and had enhanced appositional bone formation, whereas OCP/Col samples in the G group tended to lose their height and shape and had limited appositional bone formation. The appositional bone formation increased along with growing density of OCP/Col, and L2.0 demonstrated higher appositional bone formation than other samples. These results suggest that the pre‐freezing conditions and densities of OCP/Col affect the appositional bone formation.

show abstract

Single‐dose local administration of teriparatide with a octacalcium phosphate collagen composite enhances bone regeneration in a rodent critical‐sized calvarial defect

Cited by 21 publications

References 31 publications

Bone regeneration by freeze‐dried composite of octacalcium phosphate collagen and teriparatide

Bone regeneration by freeze‐dried composite of octacalcium phosphate collagen and teriparatide

Bone augmentation by octacalcium phosphate and collagen composite coated with poly‐lactic acid cage

Influence of pre‐freezing conditions of octacalcium phosphate and collagen composite for reproducible appositional bone formation

Contact Info

Product

Resources

About