Single-dose and multi-dose clindamycin therapy fails to demonstrate efficacy in preventing infectious and inflammatory complications in third molar surgery

Kaczmarzyk, Tomasz; Wichlinski, J.; Stypulkowska, J.; Zaleska, Małgorzata; M, Panas; Woroń, Jarosław

doi:10.1016/j.ijom.2006.12.003

Cited by 66 publications

(60 citation statements)

References 26 publications

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“…Patients with no pain were significantly more in group II followed by group I on day 5. In contrast to the studies done by Sekhar et al 15 and Kaczmarzyk et al, 16 no statistically significant difference was found among the study groups in terms of pain and mouth opening. Therefore, routine prescription and the use of preoperative or postoperative antibiotics during extraction of the third molars fail to show any advantage.…”

contrasting

confidence: 82%

Effectiveness of Antimicrobial Therapy after Extraction of Impacted Mandibular Third Molar: A Randomized Clinical Trial

Rabi

Maheshwari

Bhuvaneshwari

et al. 2018

The Journal of Contemporary Dental Practice

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Aim: The present study was conducted with the aim of evaluating the effectiveness of antimicrobial therapy following extraction of an impacted mandibular third molar. Materials and methods:This randomized controlled trial was conducted on a total of 60 patients who were randomly assigned into three groups: Group I individuals were given 625 mg of combined amoxicillin and clavulanic acid tablet; 625 mg of combined amoxicillin and clavulanic acid tablet + 400 mg metronidazole tablet was given to group II individuals; whereas group III individuals were assigned no treatment. All the individuals underwent surgical extraction of impacted mandibular third molars under strict aseptic techniques, with minimal trauma to the surrounding tissues. Mouth opening in millimeters was recorded postoperatively using Vernier calipers on the 1st, 3rd, 5th, and 7th days. A 4-point visual analog scale (VAS) was used for assessing postoperative pain. Patient satisfaction was further assessed in a subjective manner using a graded scale from "very satisfied" to "very unsatisfied". better satisfaction than the other group individuals. There was no statistically significant difference between the mean age of groups. It was observed that on day 3, the number of individuals with severe pain was slightly reduced in the group I compared with group III individuals. On day 5, participants with no pain were significantly more in group II followed by group I. Furthermore, there was a statistically significant difference between the study groups with respect to mouth opening on days 3 and 5. Results Conclusion:It was concluded from this trial that the administration of postoperative antimicrobials showed no significant differences in the degree of postoperative complications that occur following the surgical extraction of impacted mandibular third molars.Clinical significance: Antimicrobial drugs are routinely used to reduce the chances of surgical site infection, either preoperatively or postoperatively. Therefore, the clinicians should have sound knowledge about choosing the better antimicrobial drug after the extraction of impacted third molars.

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contrasting

confidence: 82%

Effectiveness of Antimicrobial Therapy after Extraction of Impacted Mandibular Third Molar: A Randomized Clinical Trial

Rabi

Maheshwari

Bhuvaneshwari

et al. 2018

The Journal of Contemporary Dental Practice

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“…Each page of this booklet represented one pain measurement moment (preoperative, immediate postoperative, 1, 2, 4, 12 hours; 1, 2, 3 and 7 postoperative days). Patients were oriented to mark with a trace on the horizontal line to reflect pain intensity, considering zero as no pain and 10 as maximum possible pain 26 . Volunteers were asked to personally return the booklet with filled VAS when they returned for the seventh postoperative day consultation.…”

Section: Pain Evaluationmentioning

confidence: 99%

Evaluation of effects of two dexamethasone formulations in impacted third molar surgeries

et al. 2014

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BACKGROUND AND OBJECTIVES:Submucosal dexamethasone injection directly in the surgical area has been used in different dental procedures, but there are still few studies evaluating its efficacy as compared to oral route for impacted third molar surgeries. So, this study aimed to evaluate postoperative pain, edema and trismus after impacted third molar surgeries using oral or submucosal local injection of dexamethasone. METHODS:This was a prospective, controlled, crossover and randomized study involving 36 patients with indication of lower third molar surgeries, who were randomly distributed in two groups: group A -submucosal local injection of dexamethasone (4mg/1mL) after local anesthesia, and group B -oral dexamethasone tablet (4mg) one hour before procedure. Edema and trismus were clinically evaluated in the postoperative period and in the 1 st , 2 nd , 3 rd and 7 th postoperative days. Patients were oriented to record pain intensity in the visual analog scale in periods zero (preoperative), 1h, 2h, 4h, 12h, 1 day, 2 days and 3 days and one week after surgery. Data were submitted to statistical analysis with significance level of 5%. RESULTS: There were no significant differences in surgical time with regard to operated sides (p=0.4). Edema and trismus values were not statistically different between observed groups (p>0.05). Mean pain values recorded in the visual analog scale were not statistically different between groups and patients have Evaluation of effects of two dexamethasone formulations in impacted third molar surgeries* Avaliação dos efeitos de duas formulações de dexametasona em cirurgias de terceiros molares inclusos

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“…In studies done by Sekhar et al, [2] and Kaczmarzyk et al, [11] no significant differences were seen among the groups in terms of pain, mouth opening and swelling and hence, they failed to show any advantage which was associated with routine preoperative or postoperative use of antibiotics during removal of third molars.…”

Section: Discussionmentioning

confidence: 89%

Efficacy of Postoperative Prophylactic Antibiotic Therapy in Third Molar Surgery

S¹

2014

JCDR

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Introduction: Surgical extraction of mandibular third molar is the most frequently performed procedure in oral surgery. This procedure is associated with significant postoperative sequelae such as trismus, swelling, pain and infection. The need of antibiotic therapy during the removal of mandibular third molar has been a contentious issue. Method:This study investigated a regimen by using amoxycillin and metronidazole in one group and without using antibiotics in the other. Both the groups were assessed postoperatively on the 1 st , 2 nd , 5 th , 7 th and 10 th days by the same observer for post operative mouth opening (interincisal distance), presence of a purulent discharge at the site of surgery, pain and swelling.Result: Overall, no statistically significant difference was seen between both the treatment groups when interincisal distance, pain, swelling and purulent discharge were considered. Conclusion:The results of this study failed to show any advantage which was associated with the routine postoperative use of antibiotics in asymptomatic third molar surgeries.

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Single-dose and multi-dose clindamycin therapy fails to demonstrate efficacy in preventing infectious and inflammatory complications in third molar surgery

Cited by 66 publications

References 26 publications

Effectiveness of Antimicrobial Therapy after Extraction of Impacted Mandibular Third Molar: A Randomized Clinical Trial

Effectiveness of Antimicrobial Therapy after Extraction of Impacted Mandibular Third Molar: A Randomized Clinical Trial

Evaluation of effects of two dexamethasone formulations in impacted third molar surgeries

Efficacy of Postoperative Prophylactic Antibiotic Therapy in Third Molar Surgery

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