2019
DOI: 10.1101/590547
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Abstract: Most human tumors display chromosome-scale copy number alterations, and high levels of aneuploidy are frequently associated with advanced disease and poor patient prognosis. To examine the relationship between aneuploidy and cancer progression, we generated and analyzed a series of congenic human cell lines that harbor single extra chromosomes. We find that different aneuploidies can have distinct effects on invasive behavior: across 13 different cell lines, 12 trisomies suppressed invasiveness or were largely… Show more

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Cited by 5 publications
(7 citation statements)
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“…Recent in vitro studies also support the idea of specific recurrent aneuploidies promoting metastasis: while most single trisomies suppress metastatic potential in human cancer cell lines (as evaluated by in vitro proxies of metastasis), some promote it 79 .…”
Section: Does Aneuploidy Promote Metastasis?mentioning
confidence: 88%
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“…Recent in vitro studies also support the idea of specific recurrent aneuploidies promoting metastasis: while most single trisomies suppress metastatic potential in human cancer cell lines (as evaluated by in vitro proxies of metastasis), some promote it 79 .…”
Section: Does Aneuploidy Promote Metastasis?mentioning
confidence: 88%
“…Congruently, a recent analysis of data from The Cancer Genome Atlas (TCGA) revealed that CNA burden (to which aneuploidy is the major contributor) is significantly associated with disease-free and overall survival in primary breast, endometrial, renal clear cell, thyroid, and colorectal cancers 109 . A recent TCGA analysis used more direct aneuploidy scores, that take into account only arm-level and chromosome-level alterations, and found highly-aneuploid tumors to be associated with a significantly worse prognosis in 9 out of 27 tumor types 79 .…”
Section: The Prognostic Value Of Degree Of Aneuploidymentioning
confidence: 99%
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“…To resolve this conundrum, we turned to isogenic models of TP53-WT near-diploid cells and their highly-aneuploid derivatives, based on HCT116, a chromosomally-stable, near-diploid human colon cancer cell line 54 , and RPE1, a chromosomally-stable, neardiploid non-transformed human retinal epithelial cell line 55 , that are commonly used to study the cellular effects of aneuploidy 16,20,[56][57][58][59][60][61][62][63][64][65][66][67][68][69] . We induced cytokinesis failure in these cells, thus generating tetraploid cells, which then spontaneously became highly aneuploid 70 .…”
Section: The Effect Of Aneuploidy On the Sensitivity To Sac Inhibitiomentioning
confidence: 99%
“…Those peripheral domains are mainly low gene expression regions that contain histone marks of a silenced state (Smith et al 2021). There is an increasing number of evidences that allows a less restricted nuclear organization in pluripotent cells, hereof increasing the intranuclear plasticity regarding not only to expression and organization but also to genomic instability (Vasudevan et al 2020;Dhegihan 2021).…”
Section: Influence Of Genomic Arrangement In the Nucleus On Aneuploidymentioning
confidence: 99%