Single cell array impedance analysis in a microfluidic device

Altinagac, Emre; Taskin, Selen; Kızıl, Hüseyin

doi:10.1088/1742-6596/757/1/012010

Cited by 2 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further work is needed to explore the design and components, optimization of fabrication and detection methodology, and analysis of the reactivity of various drugs within the system. Apart from the drug delivery applications, integrated microfluidic devices have been explored for various biomedical sensing applications such as pathogen detection, and single cell and cell culture analysis using impedance spectroscopy [ 38 , 39 , 40 , 41 , 42 ] ( Table 4 ). The present work takes the initiative of detecting essential oils, which are also gaining enormous attention in medical applications suggesting a huge opportunity for their utilization in the coming time.…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Gold Leaf-Based Microfluidic Platform for Detection of Essential Oils Using Impedance Spectroscopy

et al. 2022

View full text Add to dashboard Cite

Drug delivery systems are engineered platforms for the controlled release of various therapeutic agents. This paper presents a conductive gold leaf-based microfluidic platform fabricated using xurography technique for its potential implication in controlled drug delivery operations. To demonstrate this, peppermint and eucalyptus essential oils (EOs) were selected as target fluids, which are best known for their medicinal properties in the field of dentistry. The work takes advantage of the high conductivity of the gold leaf, and thus, the response characteristics of the microfluidic chip are studied using electrochemical impedance spectroscopy (EIS) upon injecting EOs into its micro-channels. The effect of the exposure time of the chip to different concentrations (1% and 5%) of EOs was analyzed, and change in electrical resistance was measured at different time intervals of 0 h (the time of injection), 22 h, and 46 h. It was observed that our fabricated device demonstrated higher values of electrical resistance when exposed to EOs for longer times. Moreover, eucalyptus oil had stronger degradable effects on the chip, which resulted in higher electrical resistance than that of peppermint. 1% and 5% of Eucalyptus oil showed an electrical resistance of 1.79 kΩ and 1.45 kΩ at 10 kHz, while 1% and 5% of peppermint oil showed 1.26 kΩ and 1.07 kΩ of electrical resistance at 10 kHz respectively. The findings obtained in this paper are beneficial for designing suitable microfluidic devices to expand their applications for various biomedical purposes.

show abstract

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Gold Leaf-Based Microfluidic Platform for Detection of Essential Oils Using Impedance Spectroscopy

et al. 2022

View full text Add to dashboard Cite

show abstract

“…1 These include, but are not limited to, environmental analysis, food monitoring, security, forensics, and healthcare. [2][3][4][5][6][7][8] Arguably, most of the effort is being devoted toward the development of the applications in the lattermost category. Microfluidic lab-on-chips that can perform tasks such as diagnosis and biological compound sensing form viable alternatives to traditional laboratory setups.…”

Section: Introductionmentioning

confidence: 99%

Gold-on-glass microwave split-ring resonators with PDMS microchannels for differential measurement in microfluidic sensing

et al. 2020

View full text Add to dashboard Cite

This paper describes a microwave resonator incorporating microfluidic lab-on-chip sensor system capable of performing simultaneous differential measurement based sensing of liquid samples. The resonators are split-ring resonator shapes made of gold on glass substrates. Directly bonded on glass substrates are polydimethylsiloxane microchannels. Sensor system design incorporates a pair of identical resonators, one of which performs reference reading from the background. Tracking the difference of the responses of both resonators simultaneously, rather than a single one, is used to obtain a more linear and noise-free reading. The sensor system was produced with conventional fabrication techniques. It is compatible with low-cost, simple, easy to handle sensing applications. Results indicate that reliable differential measurement was possible owing to a well-matched pair of sensors with a response error as low as 0.1%. It was also demonstrated that differential measurement capability enables sensing with improved linearity. Measurements were performed with glucose solutions in the range of 3.2-16.1 mM, achieving a sensitivity of 0.16 MHz/mM.

show abstract

Single cell array impedance analysis in a microfluidic device

Cited by 2 publications

References 8 publications

Gold Leaf-Based Microfluidic Platform for Detection of Essential Oils Using Impedance Spectroscopy

Gold Leaf-Based Microfluidic Platform for Detection of Essential Oils Using Impedance Spectroscopy

Gold-on-glass microwave split-ring resonators with PDMS microchannels for differential measurement in microfluidic sensing

Contact Info

Product

Resources

About