2011
DOI: 10.1590/s0102-67202011000200002
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Abstract: -Background -The leading cause of death in patients with sepsis in surgery is syndrome of multiple organ dysfunction. Thus, experimental models that simulate organic changes of sepsis in humans are required. Aim -To present two models that induce the syndrome of multiple organ dysfunction and to compare, the changes induced, by intravenous injection of lipopolysaccharide or cell 36UE of viable Escherichia coli in relation to mortality and survival, level of lipopolysaccharide, release of tumor necrosis factor … Show more

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Cited by 7 publications
(3 citation statements)
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“…In response to bacterial infectious stimulation serum procalcitonin rises substantially and its role in inflammatory response includes chemotactic function, modulation of inducible nitric oxide synthase and induction of cytokines, among other [1][2][3][4][5] . Several studies have shown that the measurement of procalcitonin is highly sensitive and specific for distinguishing SIRS (systemic inflammatory response syndrome) 6 from sepsis, bacterial pneumonia of other inflammatory lung conditions 7 and pancreatic necrosis from septic pancreas necrosis 8 .…”
mentioning
confidence: 99%
“…In response to bacterial infectious stimulation serum procalcitonin rises substantially and its role in inflammatory response includes chemotactic function, modulation of inducible nitric oxide synthase and induction of cytokines, among other [1][2][3][4][5] . Several studies have shown that the measurement of procalcitonin is highly sensitive and specific for distinguishing SIRS (systemic inflammatory response syndrome) 6 from sepsis, bacterial pneumonia of other inflammatory lung conditions 7 and pancreatic necrosis from septic pancreas necrosis 8 .…”
mentioning
confidence: 99%
“…In this study, the induction of disseminated infection after intravenous infection was adopted because it is a simple, easily controlled and reproducible method (Lima et al 2011). Infections caused by S. aureus were analysed in different aspects considering the control group as standard.…”
Section: Discussionmentioning
confidence: 99%
“…inflammatory response includes chemotactic function modulation of inducible nitric oxide synthase and induction of cytokines, among other. [6][7][8][9][10][11] The identification of a prognostic marker that may predict the outcome at the end of 24 to 48 hours of treatment of severe sepsis and septic shock could be very useful in order to provide a reassessment of the patient, identifying perpetuators of gravity, permitting interventions and conduct reorientation. The addition of this marker for the routine evaluation of patients with severe sepsis and septic shock treated according to the surviving sepsis campaign strategies might bring additional contribution towards reducing morbidity and mortality.…”
mentioning
confidence: 99%