Sinapic acid-loaded chitosan nanoparticles in polycaprolactone electrospun fibers for bone regeneration in vitro and in vivo

Balagangadharan, K.; Trivedi, Ritu; Vairamani, M.; Selvamurugan, N.

doi:10.1016/j.carbpol.2019.04.002

Cited by 77 publications

(42 citation statements)

References 93 publications

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“…Moreover, AP-NPs were non-toxic in in vitro BMSCs model. Also, sinopic acid-loaded chitosan NPs (SA-CH-NPs) promoted osteogenesis in vivo (observed as better regeneration of cervical bone) [76]. Those results corresponded with in vitro assessment, where NPs were non-toxic and promoted osteoblast formations from BMSCs through activation of the TGF-ß1/BMP/Smads/Runx2 pathway [76].…”

Section: Nanoparticles In Bone Regenerative Strategiesmentioning

confidence: 64%

“…Also, sinopic acid-loaded chitosan NPs (SA-CH-NPs) promoted osteogenesis in vivo (observed as better regeneration of cervical bone) [76]. Those results corresponded with in vitro assessment, where NPs were non-toxic and promoted osteoblast formations from BMSCs through activation of the TGF-ß1/BMP/Smads/Runx2 pathway [76]. Study designed by Kuang et al is especially interesting because they created an injectable material containing nanocomposite hydrogel and CaPNPs [77].…”

Section: Nanoparticles In Bone Regenerative Strategiesmentioning

confidence: 85%

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Modified Nanoparticles as Potential Agents in Bone Diseases: Cancer and Implant-Related Complications

Steckiewicz

Inkielewicz‐Stępniak

2020

Nanomaterials

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Materials sized 1–100 nm are the nanotechnology’s field of interest. Because of the unique properties such as the ability to penetrate biological barriers and a high surface to volume ratio, nanoparticles (NPs) are a powerful tool to be used in medicine and industry. This review discusses the role of nanotechnology in bone-related issues: osteosarcoma (bone cancer), the biocompatibility of the implants and implant-related infections. In cancer therapy, NPs can be used as (I) cytotoxic agents, (II) drug delivery platforms and (III) in thermotherapy. In implant-related issues, NPs can be used as (I) antimicrobial agents and (II) adjuvants to increase the biocompatibility of implant surface. Properties of NPs depend on (I) the type of NPs, (II) their size, (III) shape, (IV) concentration, (V) incubation time, (VI) functionalization and (VII) capping agent type.

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Section: Nanoparticles In Bone Regenerative Strategiesmentioning

confidence: 64%

Section: Nanoparticles In Bone Regenerative Strategiesmentioning

confidence: 85%

Modified Nanoparticles as Potential Agents in Bone Diseases: Cancer and Implant-Related Complications

Steckiewicz

Inkielewicz‐Stępniak

2020

Nanomaterials

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“…At concentrations of 250 μM and more, there were no significant changes in the expression of Runx2 mRNA by Zg treatment compared to control (data not shown). No change or decrease in mRNA expression at higher concentration of Zg might be due to the negative feedback mechanism/regulation of the Runx2 gene . Hence, Zg at a concentration of 200 μM was used in the following experiments for determining its osteogenic action.…”

Section: Resultsmentioning

confidence: 99%

“…No change or decrease in mRNA expression at higher concentration of Zg might be due to the negative feedback mechanism/regulation of the Runx2 gene. 15 Hence, Zg at a concentration of 200 μM was used in the following experiments for determining its osteogenic action.…”

Section: Zg Treatment Stimulated Runx2 Mrna Expression In Mmscsmentioning

confidence: 99%

Osteogenic potential of zingerone, a phenolic compound in mouse mesenchymal stem cells

et al. 2019

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Zingerone, 4‐(4‐hydroxy‐3‐methoxyphenyl)‐2‐butanone (Zg), a phenolic compound isolated from ginger is reported to have anti‐inflammatory and antidiabetic properties. However, its role in the promotion of osteogenesis is not known. In this study, we investigated the therapeutic effect of Zg on osteogenesis at the cellular and molecular levels. Zg treatment was nontoxic to mouse mesenchymal stem cells (mMSCs). At the cellular level, it enhanced osteoblast differentiation as evidenced by more calcium deposits. At the molecular level, Zg stimulated the expression of Runx2 (a bone transcription factor) and other marker genes of osteoblast differentiation in mMSCs. Recent studies indicated that microRNAs (miRNAs) regulate bone metabolism, and we identified that Zg treatment in mMSCs upregulated mir‐590, a positive regulator of Runx2 by targeting Smad7, an antagonist of TGF‐β1 signaling. Thus, the osteogenic potential of Zg would be beneficial for treating bone and bone‐related diseases.

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“…CS has properties such as biocompatibility and biodegradability . It can be processed into porous structures and films for application in tissue regeneration, wound dressings, and drug delivery systems . Although CS has these advantages, it is mechanically weak and lacks bioavailability.…”

Section: Introductionmentioning

confidence: 99%

Chitosan in Surface Modification for Bone Tissue Engineering Applications

Abinaya

Prasith

Ashwin

et al. 2019

Biotechnology Journal

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Traditional methods of bone defect repair include autografts, allografts, surgical reconstruction, and metal implants that have several disadvantages such as donor site morbidity, rejection, risk of disease transmission, and repetitive surgery. Biomaterial‐based bone reconstructions can, therefore, be an efficient alternative due to the inherent properties of the materials. Chitosan (CS), the deacetylated form of chitin, is a biopolymer having a wide array of applicability in regenerative tissue applications owing to its biocompatible, in vitro degradative and bioresorbable nature. Extensive studies are being carried out using CS to augment the properties of the already existing methods and to also improve the applicability of CS‐based biocomposites in bone tissue repair. In this review, the suitability of CS as a surface modifier has been discussed in detail for the already existing implants, surface modifications of CS‐based natural biocomposites for bone tissue regeneration, and the wide range of techniques that can introduce these modifications. CS, being a natural polymer, possesses advantageous properties including surface modifier that makes it a suitable candidate for bone regeneration, and further research to investigate its osteogenic potential in vivo along with the molecular and signaling mechanisms involved in bone regeneration can aid in expanding its applicability in clinical trials.

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Sinapic acid-loaded chitosan nanoparticles in polycaprolactone electrospun fibers for bone regeneration in vitro and in vivo

Cited by 77 publications

References 93 publications

Modified Nanoparticles as Potential Agents in Bone Diseases: Cancer and Implant-Related Complications

Modified Nanoparticles as Potential Agents in Bone Diseases: Cancer and Implant-Related Complications

Osteogenic potential of zingerone, a phenolic compound in mouse mesenchymal stem cells

Chitosan in Surface Modification for Bone Tissue Engineering Applications

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