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Cited by 33 publications
(27 citation statements)
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References 26 publications
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“…In addition, patients in Group B received have been received simvastatin 3% ointment twice daily. [20] Patients were advised to report the occurrence of any unwilling adverse effects (redness, burning, itching and erosion) during the 12 weeks of the study.…”
Section: Methodsmentioning
confidence: 99%
See 2 more Smart Citations
“…In addition, patients in Group B received have been received simvastatin 3% ointment twice daily. [20] Patients were advised to report the occurrence of any unwilling adverse effects (redness, burning, itching and erosion) during the 12 weeks of the study.…”
Section: Methodsmentioning
confidence: 99%
“…In spite of the confirmed effectiveness of oral simvastatin in the treatment of psoriasis, data in favor of the anti-inflammatory and wound healing potentials of the topical application of simvastatin has been confirmed. [1920] Taken together, by incorporation of simvastatin in ointment formulation, a topical form of the drug is formed. [20]…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…In lipopolysaccharide-stimulated B lymphocytes lovastatin inhibited the proliferation and differentiation of B cells and induced cell apoptosis (Reedquist et al, 1995). Recently, new data emerged demonstrating that topical administration of simvastatin by diminishing inflammation and increasing angiogenesis has beneficial effects in skin inflammatory conditions and wound healing (Asai et al, 2012;Adami et al, 2012). Statins have also been shown to increase the expression of heme-oxygenase-1 (HO-1) (Leung et al, 2011).…”
Section: Anti-inflammatory Effectsmentioning
confidence: 99%
“…In preclinical studies, simvastatin ointment has been shown to improve chronic skin inflammation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) at lower concentration but worsened skin inflammation at higher concentration (Adami et al 2012). Atorvastatin and other statins have shown anti-inflammatory action in acute model of skin inflammation induced by croton oil (Bracht et al 2011).…”
Section: Introductionmentioning
confidence: 99%