Simvastatin loaded composite polyspheres of gellan gum and carrageenan: In vitro and in vivo evaluation

Kulkarni, Raghavendra V.; Nagathan, Vineeta V.; Biradar, Prakash R.; Naikawadi, Akram A.

doi:10.1016/j.ijbiomac.2013.03.027

Cited by 36 publications

(14 citation statements)

References 24 publications

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“…The best pharmacokinetic fitting model was Kores Meyer and Peppa's model. The R2 values of optimized formulae SE2 and IG2 were found to be 0.9902 and 0.9932, respectively (Table 5) [20]. The in vivo activity showed better action for both methods by reducing cholesterol and triglyceride level.…”

Section: Discussionmentioning

confidence: 91%

“…The plasma was estimated for cholesterol and triglycerides using diagnostic kits (Erba Ltd. India). Fixed volumes mentioned in the leaflets of kits of the standard were prepared for reference, and a working reagent was added to the plasma of each group and kept aside for 10 min and simultaneously blank was prepared by omitting the sample and absorbed spectrophotometrically at 505 nm and 546 nm for cholesterol and triglycerides respectively [20].…”

Section: In Vivo Antihyperlipidemic Drug Action In Albino Ratsmentioning

confidence: 99%

“…They were then characterized for entrapment efficiency and in vitro drug release study after storing at room temperature and -2˚C. They were estimated for one-month intervals for 3 months to verify both parameters [20]. The solubility study for the polymeric NPs was based on the solubility profile of the Fluvastatin sodium drug.…”

Section: Stability Studiesmentioning

confidence: 99%

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Role of Fluvastatin sodium loaded polymeric nanoparticles in the treatment of Hyperlipidemia: Fabrication and Characterization

Gudigennavar¹,

Chandragirvar²,

Gudigennavar³

2023

German J. Pharm. Biomaterials

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The present work is focused on the formulation and evaluation of polymeric nanoparticles (NPs) loaded by Fluvastatin sodium (FLS). This drug has many disadvantages, including bioavailability of up to 24 to 44% and a half-life of approximately 30 min to 60 min. Also, it comes under Biopharmaceutical classification system (BCS) class III, but it is sparingly soluble in water. Polymeric NPs were prepared using gum rosin and chitosan as polymers which Solvent Evaporation and Inotropic Gelation method prepared. Prepared polymeric NPs were characterized for respective parameters like drug entrapment efficiency, particle size, zeta potential, Differential Scanning Calorimetry, X-Ray Diffraction, Scanning Electron Microscopy, Transmission Electron Microscopy, In vitro and In vivo drug release study. The average Particle size was lay within the range of 271 nm to 313.3 nm for the Solvent Evaporation method (SE) and 123.3 nm to 382 nm for the Inotropic gelation method (IG). Drug entrapment efficiency (DEE) of SE3 was found to be 86.1%, and IG3 had 70.2%. In vitro release study showed sustained action for both methods at the end of 48 h; an increase in the polymer resulted in decreased drug release. From the study, it can be concluded that prepared polymeric NPs from both methods show significant hypolipidemic activity. Stability studies showed that formulations are stable at the end of 3 months.

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Section: Discussionmentioning

confidence: 91%

Section: In Vivo Antihyperlipidemic Drug Action In Albino Ratsmentioning

confidence: 99%

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Role of Fluvastatin sodium loaded polymeric nanoparticles in the treatment of Hyperlipidemia: Fabrication and Characterization

Gudigennavar¹,

Chandragirvar²,

Gudigennavar³

2023

German J. Pharm. Biomaterials

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“…The size of IPN microbeads was reduced due to crosslinking with GA because of rapid polymer chain shrinkage producing smaller and stiffer IPN microbeads at higher crosslink density. 36 The DEE of IPN microbeads ranged between 76% and 88% (Table 3). The DEE is higher for microbeads prepared using higher Ca 2+ concentration than those prepared with lower Ca 2+ concentration.…”

Section: Sem Size and Deementioning

confidence: 99%

In vitro and in vivo assessment of novel pH-sensitive interpenetrating polymer networks of a graft copolymer for gastro-protective delivery of ketoprofen

et al. 2016

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“…Muitos trabalhos da literatura procuram demonstrar o potencial desse composto como modulador de liberação em grânulos produzidos por geleificação ionotrópica. Nesse caso o polissacarideo é adicionado a uma solução contendo um reticulante, ou vice-versa, de modo que um polímero reticulado é produzido para controlar a liberação do fármaco (KULKARNI et al, 2013;PREZOTTI et al, 2014;SAHOO et al, 2015;CERCIELLO et al, 2016).…”

Section: Introductionunclassified

Avaliação da goma gelana como aglutinante em formulações de pellets contendo teofilina

Barbosa¹

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À minha família pelo suporte em todos esses anos de estudos. Ao prof. Dr. Humberto Gomes Ferraz, pela oportunidade de aprender, e de enfrentar desafios na busca pelo conhecimento e inovação. À Universidade de São Paulo, por proporcionar que seus alunos possam aprender e divulgar o conhecimento. Aos professores das disciplinas de pós-graduação, com quem pude aprender e participar de discussões. Aos funcionários da Faculdade de Ciências Farmacêuticas, em especial aos funcionários do Departamento de Fármacia, pelo suporte durante o período. À FIPFARMA e seus funcionários, pelo auxílio durante o período. A todos os colaboradores do Deinfar pelo auxílio e contribuição para o meu trabalho. Em especial à Amanda Campos, Felipe Fernandes, Leandro Giorgetti, Michele Issa e Marcelo Duque, pelas discussões e sugestões; aos colaboradores Franz, Diego Aroca, e Gabriela "little deut", pela ajuda com os experimentos; e à Eremita, por sua ajuda com os suprimentos e suporte técnico. À profª. Drª. Nádia Araci Bou Chacra e seus alunos, por gentilmente disponibilizar seus equipamentos. Aos amigos que fiz durante o período. À Capes pelo auxílio financeiro concedido. À CPKelco Brasil, e a todas as empresas que gentilmente nos forneceram os materias.

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Simvastatin loaded composite polyspheres of gellan gum and carrageenan: In vitro and in vivo evaluation

Cited by 36 publications

References 24 publications

Role of Fluvastatin sodium loaded polymeric nanoparticles in the treatment of Hyperlipidemia: Fabrication and Characterization

Role of Fluvastatin sodium loaded polymeric nanoparticles in the treatment of Hyperlipidemia: Fabrication and Characterization

In vitro and in vivo assessment of novel pH-sensitive interpenetrating polymer networks of a graft copolymer for gastro-protective delivery of ketoprofen

Avaliação da goma gelana como aglutinante em formulações de pellets contendo teofilina

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