Simultaneous whole-body and breast 18F-FDG PET/MRI examinations in patients with breast cancer: a comparison of apparent diffusion coefficients and maximum standardized uptake values

Abstract

Prone breast imaging was more sensitive than whole-body PET/MRI for detection of breast cancers. Both SUVmax and ADCmean showed limited correlation with pathologic prognostic factors.

PET/MRI in Breast Cancer

“…In a study by Kong et al, only 4/10 (40%) subcentimeter breast cancers were seen on whole‐body PET/MRI . In a study by Sasaki et al, primary breast cancers were seen in all 94 patients on dedicated prone breast/MRI, while whole‐body PET‐MRI did not identify primary breast cancers in 7/94 (7%) patients . Therefore, in patients with elevated tumor markers and negative whole‐body imaging, consideration may be given to dedicated breast imaging.…”

Associations Between PET Parameters and Expression of Ki-67 in Breast Cancer

“…For example, numerous reports suggested that PET parameters, such as the maximal standardized uptake value (SUV max ), depended on the histologic and biologic characteristics of the breast tumor [5] , [6] . Invasive tumors classified exhibit higher uptake than lower-grade tumors [5] , [6] , [7] . Furthermore, PET parameters can also predict behavior of BC [8] , [9] , [10] , [11] , [12] .…”

“…Imaging methods, especially mammography, ultrasound and magnetic resonance imaging, play a fundamental role in the diagnosis of BC [2] . Nowadays, also positron emission tomography (PET) is increasingly used in BC [3] , [4] , [5] , [6] , [7] . It has been shown that PET besides detection of distant metastases can also provide additional information about tumor histopathology [5] , [6] , [7] , [8] .…”

“…Nowadays, also positron emission tomography (PET) is increasingly used in BC [3] , [4] , [5] , [6] , [7] . It has been shown that PET besides detection of distant metastases can also provide additional information about tumor histopathology [5] , [6] , [7] , [8] . For example, numerous reports suggested that PET parameters, such as the maximal standardized uptake value (SUV max ), depended on the histologic and biologic characteristics of the breast tumor [5] , [6] .…”

“…Presumably, metabolic activity showing by PET may be associated with biological patterns of BC. In fact, some studies also indicated that PET parameters can also provide information about tumor microstructure in BC [4] , [5] , [7] . For example, Heudel et al observed significant correlations between SUV and histological grade ( P < 0.0001), histological type ( P = 0.001), tumor size ( P < 0.0435), estrogen receptor status ( P < 0.0005), and progesterone receptor status ( P = 0.002) [13] .…”