2006
DOI: 10.1007/s00280-006-0208-7 View full text |Buy / Rent full text
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Abstract: The preliminary data in rats suggest that simultaneous release of a hydrophilic cytostatic and a hydrophilic contrast agent from an interstitial depot can be achieved by encapsulation in liposomes. Thus, there seems to be a potential for indirect drug monitoring through imaging.

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“…Sampson and coworkers deliver MRI contrast agents to brain tumors, but no quantification of the agent's concentration is performed [18, 19]. Krauze et al [20] and Port et al [21] imaged liposomal Gd-DTPA delivery, but neither quantified concentration. Fritz-Hansen et al calculated bulk concentration of contrast in arterial blood, but, was not concerned with spatial distribution [22].…”
Section: Introductionmentioning
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“…Sampson and coworkers deliver MRI contrast agents to brain tumors, but no quantification of the agent's concentration is performed [18, 19]. Krauze et al [20] and Port et al [21] imaged liposomal Gd-DTPA delivery, but neither quantified concentration. Fritz-Hansen et al calculated bulk concentration of contrast in arterial blood, but, was not concerned with spatial distribution [22].…”
Section: Introductionmentioning
“…tumors or atherosclerotic plaques) or containing high amount of macrophages (liver, spleen), (iv) easiness to prepare vesicles able to recognize a specific biological target. Liposomes loaded with paramagnetic Mn(II)-or Gd(III)-based imaging reporters or superparamagnetic iron oxide particles have been investigated for many applications including passive and active tumor visualization [3][4][5][6][7], detection of myocardium infarcted areas [8], imaging of lymph nodes [9], visualization of atherosclerotic plaques [10], detection of multiple sclerosis [11], bone marrow visualization [12], detection of apoptosis [13], in vivo monitoring of temperature [14] or pH [15], and imaging of drug delivery [16,17]. In addition, liposomes loaded with paramagnetic lanthanide(III) complexes, mostly different from Gd(III), have been recently proposed as highly sensitive MRI agents acting as chemical exchange saturation transfer (CEST) probes [18][19][20][21] or as T 2 susceptibility agents [22].…”
Section: Introductionmentioning
“…256 have been loaded into the porous organic or inorganic shells of the surface-modified magnetic nanoparticles. Some of the general issues or challenges associated with the deployment of magnetic nanoparticles for drug delivery (or gene delivery) applications include (i) improving biocompatibility or obtain control over in vivo behavior, (ii) achieving control over bioelimination (which includes preventing unwanted clearance and enabling safe clearance when desired), (iii) improving specific targeting, (iv) minimizing the polydispersity (of size, surface functionality) and (v) issues related to the limited penetration of the magnetic field deep into the body.…”
Section: Biomedical Applicationsmentioning