Simultaneous Spectrophotometric Determination of Benzoic Acid, Sorbic Acid, and Ascorbic Acid Using a Net Analyte Signal-Based Method

Abstract

The net analyte preprocessing/classical least-squares (NAP/CLS) method is a simple chemometric method that has been used for the simultaneous spectrophotometric determination of benzoic acid, sorbic acid, and ascorbic acid. The obtained results indicated that the performances of the NAP/CLS and partial least-squares methods were almost identical. The net analyte signal (NAS) concept was also used to calculate multivariate analytical figures of merit, such as LOD, selectivity, and sensitivity. Wavelength selection was applied based on the concept of NAS regression, and improved the method performance in samples containing nonmodeled interferences. The method afforded recoveries in the range of 98105. The proposed method was successfully applied to determination of the analytes in an Iranian soft drink.

Development and Validation of RP- HPLC Method for Simultaneous Determination of Ascorbic Acid and Salicylamide in their Binary Mixtures: Application to Combined Tablets

“…Several methods were reported for the determination of ASC either per se or in pharmaceutical preparations and biological fluids. The recent methods include; spectrophotometry [4][5][6], spectrofluorimetry [7], voltammetry [8][9][10], HPLC [11][12][13][14], and capillary electrophoresis [15]. Salicylamide (SAL), 2-hydroxybenzamide (Figure 1b), is a salicylic acid derivative that has analgesic, anti-inflammatory, and antipyretic actions.…”

Application of Net Analyte Signal Standard Addition Method (NASSAM) for Simultaneous Determination of Lead and Tin by Differential Pulse Polarography

“…[16][17][18] Net analyte signal calibration for a multivariate problem was originally described by Lorber. [19][20][21][22][23][24][25] Based on Lorber's definition the net analyte signal for any analyte based on spectroscopic methods is that part of the spectrum of the analyte that is orthogonal to the space spanned by the spectra of all constituents except the analyte, i.e., all interfering constituents (Fig. 1).…”

“…19 The NAS calculations are used both for estimation of the figures of merit of an analytical method and its performance including limit of detection, sensitivity and selectivity for each component 26 and for the construction of multivariate calibration models. [20][21][22][23][24][25][26] There are some reports on voltammetric determination of lead and tin by chemometrics methods 12,[27][28][29] and in this paper we develop a simple and new chemometrics method based on differential pulse polarography for simultaneous determination of Sn 2+ and Pb 2+ . With the DPP extremely overlapped peaks was obtained so they was determined by new method called net analyte signal standard addition method.…”