2013
DOI: 10.1590/s1984-82502013000200012 View full text |Buy / Rent full text
|
|

Abstract: The present study describes the development and subsequent validation of simple and accurate stability indicating RP-HPLC method for the determination of sparfloxacin and dexamethasone in pharmaceutical formulations in the presence of their stress-induced degradation products. Both the drugs and their stress-induced degradation products were separated within 10 minutes using C8 column and mixture of methanol and 0.02 M phosphate buffer pH 3.0 (60:40 v/v, respectively) as mobile phase at 270 nm using diode arra… Show more

Help me understand this report

Search citation statements

Order By: Relevance
Select...
2
1
1
0
7
0

Year Published

2015
2015
2017
2017

Publication Types

Select...
3

Relationship

2
1

Authors

Journals

0
7
0
Order By: Relevance
“…The chemistry of separating analytes plays a role when selecting appropriate chromatographic conditions. Ciprofloxacin and dexamethasone drugs can be separated through reverse-phase stationary phases because of containing major non-polar groups as well as containing unsaturated π electrons as demonstrated in our previous studies [28,36]. Polar stationary phases like cyano, can also be used as groups like (-COOH, -OH or F etc.)…”
Section: -Results and Discussionmentioning
See 2 more Smart Citations
Create an account to read the remaining citation statements from this report. You will also get access to:
  • Search over 1.2b+ citation statments to see what is being said about any topic in the research literature
  • Advanced Search to find publications that support or contrast your research
  • Citation reports and visualizations to easily see what publications are saying about each other
  • Browser extension to see Smart Citations wherever you read research
  • Dashboards to evaluate and keep track of groups of publications
  • Alerts to stay on top of citations as they happen
  • Automated reference checks to make sure you are citing reliable research in your manuscripts
  • 7 day free preview of our premium features.

Trusted by researchers and organizations around the world

Over 130,000 students researchers, and industry experts at use scite

See what students are saying

rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…The chemistry of separating analytes plays a role when selecting appropriate chromatographic conditions. Ciprofloxacin and dexamethasone drugs can be separated through reverse-phase stationary phases because of containing major non-polar groups as well as containing unsaturated π electrons as demonstrated in our previous studies [28,36]. Polar stationary phases like cyano, can also be used as groups like (-COOH, -OH or F etc.)…”
Section: -Results and Discussionmentioning
“…During initial experiments, dexamethasone peaks showed high tailing on C18, Phenyl-2, and Cyano columns but symmetrical/good peak on C8 [28,36]. However when same conditions were applied to ciprofloxacin using C8 column, tailed peak (tailing factor 1.99) was observed.…”
Section: Optimization Of Mobile Phase and Stationary Phasementioning
See 1 more Smart Citation
“…Similarly, the estimation of dexamethasone has also been reported widely by HPLC (Iqbal et al, 2006;Huetos et al, 1999; gap, the present study was designed to optimize the chromatographic conditions in order to estimate them in different matrices (pharmaceutical formulations, human urine and serum). In the past few years, different FDC have already been reported by our research group after developing suitable analytical methods Khan et al, 2013;Razzaq et al, 2013;John et al, 2015a, b;Saleem et al, 2015).…”
Section: Introductionmentioning
“…Efforts were therefore made to develop a novel, fast and validated stability indicating HPLC procedure for determining simultaneously both the drugs in pharmaceutical dosage forms and human serum. Currently we are developing analytical methods for drugs in binary combinations [16][17][18][19][20][21][22][23][24] and this study is a continuation of the previous work as it contained two active ingredients in formulation.…”
Section: Introductionmentioning