Simultaneous reconstruction of the bone and vessels for complex femoral defect

Abstract

BackgroundSeveral methods have been reported for intercalary reconstruction of femoral defects. Of these, free vascularized fibula grafts (FVFG) are preferred because of their durability, bone-healing potential, and tolerance to infection. If the bone tumor invades the femoral vessels, simultaneous vascular reconstruction also becomes necessary and significant technical hurdles make limb salvage difficult.Case presentationWe present a 10-year-old girl who underwent limb-sparing surgery for a distal femur osteosarcoma. The femoral defect was 15 cm long, and the femoral vessel defect was 10 cm long. The femur was reconstructed with bilateral FVFG, and the femoral vessels were reconstructed with saphenous vein grafts. The grafts survived without vascular compromise, and the affected limb was preserved successfully.ConclusionsCombined use of bilateral FVFG and autologous vein grafts makes limb-sparing surgery for a large osteosarcoma of the femur possible.

IL-8 Enhances Therapeutic Effects of BMSCs on Bone Regeneration via CXCR2-Mediated PI3k/Akt Signaling Pathway

“…Complex fractures can be caused by traffic accidents, resection of bone tumors, and debridement of a wide range of bone infections [1][2][3][4][5]. When the bone loss exceeds a volume threshold, the bone fails to repair the defect through autologous regeneration, and requires therapeutic approaches to maintain the limb length and restore limb function.…”