Simultaneous probing of swelling, erosion and dissolution by NMR-microimaging—Effect of solubility of additives on HPMC matrix tablets

The Impact of Dose and Solubility of Additives on the Release from HPMC Matrix Tablets—Identifying Critical Conditions

“…Owing to the low solubility of DCP, focused beam reflectance measurement (FBRM®) was used to determine the release of DCP in particulate form. The use of this technique for the purpose of studying release kinetics from tablets has been previously reported (16,17). In brief, the FBRM technique allows particle registration as a continuous beam of monochromatic laser light is launched down a probe (Lasentec®, model S400Q, Mettler Toledo, USA) with the focal point positioned at the interface between the probe window and the actual process.…”

Controlled release effervescent buccal discs of buspirone hydrochloride:in vitroandin vivoevaluation studies

“…However, with passage of time, the core of matrix also gets hydrated. The drug release from this swollen matrix is due to disentanglement of surface polymeric chains resulting in erosion and due to diffusion of media into the discs through the swollen matrix (Tajarobi et al, 2009;Chen et al, 2010;Pajander et al, 2012;Asare-Addo et al, 2013). Due to solubilization of components of matrix, the number of pores and pore diameter in swollen matrix increases thereby resulting in further drug release.…”

The Relationship Between the Evolution of an Internal Structure and Drug Dissolution from Controlled-Release Matrix Tablets

“…Dissolution and imaging data together, obtained using a non-pharmacopoeial flow-through cell, have been presented by Tajarobi et al (17) where HPMC matrices with mannitol as the soluble model of active substance have been tested. The results demonstrate that almost the entire dose of mannitol is released by the time the core of the HPMC/mannitol tablet had disappeared.…”