Simultaneous photoelectrochemical and visualized immunoassay of β-human chorionic gonadotrophin

Zhang, Nan; Ruan, Yi‐Fan; Ma, Zheng-Yuan; Zhao, Weiwei; Xu, Jing‐Juan; Chen, Hong‐Yuan

doi:10.1016/j.bios.2016.04.103

Cited by 40 publications

(15 citation statements)

References 39 publications

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“…GOx was bioconjugated onto the PbS QD/3D NiO-modified ITO electrode via the classic succinimide coupling (EDC-NHS) reaction between COOH groups on the surface of the TGA-capped PbS QDs and the NH 2 groups of GOx . The electrode was dipped into the solution containing 20 mg mL –1 EDC and 10 mg mL –1 NHS for 1 h at room temperature and then thoroughly rinsed with washing buffer.…”

Section: Methodsmentioning

confidence: 61%

Hybrid PbS Quantum Dot/Nanoporous NiO Film Nanostructure: Preparation, Characterization, and Application for a Self-Powered Cathodic Photoelectrochemical Biosensor

et al. 2017

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This work reports the first preparation and characterization of a hybrid PbS quantum dot (QD)/nanoporous NiO film nanostructure as well as its application for novel self-powered cathodic photoelectrochemical (PEC) sensing. Specifically, we synthesized the thioglycolic acid-capped PbS QDs and then assembled them onto the hydrothermally fabricated three-dimensional (3D) NiO nanostructured films on the transparent indium tin oxide-coated glass substrates, followed by the subsequent conjugation with the glucose oxidase as a model biocatalyst. Favorable alignment existed between the NiO and PbS QDs, and the as-obtained p-type heterostructure was characterized by various techniques and found to have good PEC activities. In the self-powered PEC biosensing of glucose, the system exhibited high sensitivity toward the presence of dissolved oxygen in the electrolyte, and thereby, a novel PEC enzymatic sensor was developed. With a PbS QD/3D NiO nanofilm, this work manifested the great promise of a heterostructure photocathode for a self-powered PEC biosensor that to the best of our knowledge has not been reported. We believe that it could inspire more interest in the design and development of numerous other p-type heterostructures for advanced self-powered PEC biosensors.

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Section: Methodsmentioning

confidence: 61%

Hybrid PbS Quantum Dot/Nanoporous NiO Film Nanostructure: Preparation, Characterization, and Application for a Self-Powered Cathodic Photoelectrochemical Biosensor

et al. 2017

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“…As shown in Figure , a simultaneous color change from semitransparent white to dark purple could be directly observed by the naked eye, and a complementary colorimetric analyzer could thus be built, using the color intensity as an index. Using the photographs, the corresponding value could be quantified in the blue channel with the help of Adobe Photoshop software, as illustrated in Figure S8. , Incidentally, we had also studied the pore-size (ca. 280 nm) effect of the AAO film, and the results shown in Figure S9 demonstrated the suitability of the 90 nm sample.…”

Section: Resultsmentioning

confidence: 99%

Nanochannels Photoelectrochemical Biosensor

et al. 2018

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Nanochannels have brought new opportunities for biosensor development. Herein, we present the novel concept of a nanochannels photoelectrochemical (PEC) biosensor based on the integration of a unique CuO-nanopyramid-islands (NPIs) photocathode, an anodic aluminum oxide (AAO) membrane, and alkaline phosphatase (ALP) catalytic chemistry. The CuO-NPIs photocathode possesses good performance, and further assembly with AAO yields a designed architecture composed of vertically aligned, highly ordered nanoarrays on top of the CuO-NPIs film. After biocatalytic precipitation (BCP) was stimulated within the channels, the biosensor was used for the successful detection of ALP activity. This study has not only provided a novel paradigm for an unconventional nanochannels PEC biosensor, which can be used for general bioanalytical purposes, but also indicated that the new concept of nanochannel-semiconductor heterostructures is a step toward innovative biomedical applications.

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“…Photoactive materials play critical roles in PEC systems; The PEC sensor output depends on the properties of these materials since they can influence the sensitivity and selectivity of the PEC sensor. Different photoactive materials, such as metal-based NPs [ 227 , 228 ], quantum dots (QDs) [ 229 ], carbon-based nanomaterials [ 230 ], layered nanomaterials [ 176 ], etc., have been studied in PEC application to fulfil specific demands. Furthermore, biological molecules, such as enzymes, antibodies, nucleic acids, etc., are also important for specific recognition in PEC biosensors and immunosensors.…”

Section: Application Of 2d Mos 2 -Based Nanocompos...mentioning

confidence: 99%

Functionalization of 2D MoS2 Nanosheets with Various Metal and Metal Oxide Nanostructures: Their Properties and Application in Electrochemical Sensors

2022

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Two-dimensional transition metal dichalcogenides (2D TMDs) have gained considerable attention due to their distinctive properties and broad range of possible applications. One of the most widely studied transition metal dichalcogenides is molybdenum disulfide (MoS2). The 2D MoS2 nanosheets have unique and complementary properties to those of graphene, rendering them ideal electrode materials that could potentially lead to significant benefits in many electrochemical applications. These properties include tunable bandgaps, large surface areas, relatively high electron mobilities, and good optical and catalytic characteristics. Although the use of 2D MoS2 nanosheets offers several advantages and excellent properties, surface functionalization of 2D MoS2 is a potential route for further enhancing their properties and adding extra functionalities to the surface of the fabricated sensor. The functionalization of the material with various metal and metal oxide nanostructures has a significant impact on its overall electrochemical performance, improving various sensing parameters, such as selectivity, sensitivity, and stability. In this review, different methods of preparing 2D-layered MoS2 nanomaterials, followed by different surface functionalization methods of these nanomaterials, are explored and discussed. Finally, the structure–properties relationship and electrochemical sensor applications over the last ten years are discussed. Emphasis is placed on the performance of 2D MoS2 with respect to the performance of electrochemical sensors, thereby giving new insights into this unique material and providing a foundation for researchers of different disciplines who are interested in advancing the development of MoS2-based sensors.

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Simultaneous photoelectrochemical and visualized immunoassay of β-human chorionic gonadotrophin

Cited by 40 publications

References 39 publications

Hybrid PbS Quantum Dot/Nanoporous NiO Film Nanostructure: Preparation, Characterization, and Application for a Self-Powered Cathodic Photoelectrochemical Biosensor

Hybrid PbS Quantum Dot/Nanoporous NiO Film Nanostructure: Preparation, Characterization, and Application for a Self-Powered Cathodic Photoelectrochemical Biosensor

Nanochannels Photoelectrochemical Biosensor

Functionalization of 2D MoS2 Nanosheets with Various Metal and Metal Oxide Nanostructures: Their Properties and Application in Electrochemical Sensors

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