Simultaneous Occurrence of Lichen Striatusin Siblings

Patrizi, Annalisa; Neri, Iria; Fiorentini, Cristina; Chieregato, C.; Bonci, Angela

doi:10.1111/j.1525-1470.1997.tb00961.x

Cited by 26 publications

(23 citation statements)

References 8 publications

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“…Although several studies have suggested that an infective agent could be the triggering factor in lichen striatus (6,10,21,25–27), the number of patients with symptoms of a prodromic or associated infection was too low in our series to confirm this theory. However, the possibility cannot be ruled out that the infection triggering lichen striatus may remain totally asymptomatic in the majority of affected children.…”

Section: Discussionmentioning

confidence: 55%

Lichen Striatus: Clinical and Laboratory Features of 115 Children

Patrizi¹,

Neri²,

Fiorentini³

et al. 2004

Pediatric Dermatology

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110

112

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To analyze the clinical features, response to treatment, and follow-up of lichen striatus and any associated symptoms or disease, we designed a retrospective study involving 115 affected children at the Pediatric Dermatology Unit of the Department of Dermatology of the University of Bologna, Bologna, Italy. Between January 1989 and January 2000 we diagnosed lichen striatus in 37 boys and 78 girls (mean age 4 years 5 months). We studied their family history and the season of onset, morphology, distribution, extent, duration, histopathology, and treatment of their lichen striatus. We found that family history was negative in all our patients except for two pairs of siblings. The majority of children had the disease in the cold seasons; precipitating factors were found in only five cases. The most frequently involved sites were the limbs, with no substantial difference between upper and lower limb involvement. When lichen striatus was located on the trunk and face, it always followed Blaschko lines; in seven children the bands on the limbs appeared to be along the axial lines of Sherrington. In 70 cases, lichen striatus was associated with atopy. The mean duration of the disease was 6 months and relapses were observed in five children, and in one instance the disease had a prolonged course. Only a few case study series of lichen striatus in children have been reported and ours is the largest to date. The etiology of lichen striatus remains unknown in the majority of our patients. The confirmed association with atopy observed in our patients may be a predisposing factor. It has generally been accepted that lichen striatus follows the lines of Blaschko, and this distribution is a sign of both a topographic and a pathogenetic concept. In patients where lichen striatus is along axial lines, a locus minoris resistentiae, we suppose that this distribution may only be an illusory phenomenon in instances in which the trigger factor prefers this route, consisting of several successive Blaschko lines, but appearing as a single band.

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Section: Discussionmentioning

confidence: 55%

Lichen Striatus: Clinical and Laboratory Features of 115 Children

Patrizi¹,

Neri²,

Fiorentini³

et al. 2004

Pediatric Dermatology

Self Cite

110

112

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“…78 Some speculate that LStr occurs because of the interaction of a number of specific sporadic events: atopy; viral infection at a certain age; and genetic predisposition. 79 …”

Section: Pathogenesismentioning

confidence: 97%

Lichenoid eruptions in children

Tilly

Drolet

Esterly

2004

Journal of the American Academy of Dermatology

113

118

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“…In the discussions regarding the pathogenesis of AB or adult LS, it is of interest that in these reports the cited articles always concern LS. The main hypothesis is that, beside genetic factors [29], acquired stimuli, like a viral infection [3]or a trauma, induce loss of immunotolerance resulting in a T-cell-mediated inflammatory reaction against keratinocytes, which themselves show genetic mosaicism and are arranged along the lines of Blaschko [11, 14, 16, 17, 18]. Also the hypothesis of a somatic mutation of a keratinocytic clone, which could induce an autoimmune response of the host [27], similar to the graft-versus-host reaction, is cited [15, 17, 18].…”

Section: Discussionmentioning

confidence: 99%

Lichen striatus in Adults or ‘Adult Blaschkitis’?

Hofer¹

2003

Dermatology

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Background: Lichen striatus (LS) is a well-known acquired linear inflammatory dermatosis. In 1990, Grosshans and Marot introduced the term ‘adult blaschkitis’ (AB), describing an eruption similar to LS occurring in an adult (adult LS). Does there really exist a new entity or a need for a new naming? Objective and Methods: Two new cases of adult LS are described and the data from 16 earlier cases (12 AB and 4 adult LS) are reviewed. Results: The analysis of 18 adult patients with an acquired inflammatory blaschkolinear eruption reveals that females are affected two times as frequently as males. The mean age at onset is 44 years, the mean duration until spontaneous cure 8.7 months. Relapses occur in 27.7%. In 78%, the eruption is localized on the trunk, in 55% on the arms and in 50% on the legs. Multilinearity is found in 100% if the eruption is on the trunk, and 61.5% if it is on the limbs. Neither clinical nor morphological differences exist between AB and adult LS. Conclusion: There are no convincing characteristics which justify creating a new name or even a new entity. AB may be the same as LS, a well-known acquired linear inflammatory dermatosis, which – as has been shown now – does not occur so rarely in adults. However, the etiology of this entity remains obscure.

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Simultaneous Occurrence of Lichen Striatusin Siblings

Cited by 26 publications

References 8 publications

Lichen Striatus: Clinical and Laboratory Features of 115 Children

Lichen Striatus: Clinical and Laboratory Features of 115 Children

Lichenoid eruptions in children

Lichen striatus in Adults or ‘Adult Blaschkitis’?

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