Simultaneous ERP and fMRI of the auditory cortex in a passive oddball paradigm

Liebenthal, Einat; Ellingson, Michael; Spanaki, Marianna V.; Prieto, Thomas; Ropella, Kristina M.; Binder, Jeffrey R.

doi:10.1016/s1053-8119(03)00228-3

Cited by 161 publications

(110 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These generators are believed to be located in bilateral middle and superior temporal gyrus, and bilateral inferior and middle frontal gyrus (Anderer et al, 1998;Tarkka et al, 1995;Yamazaki et al, 2000). A link between hemodynamic activity in these brain areas and the N1 ERP also are found in several recent studies that have tried to link hemodynamics (Horovitz et al, 2002;Liebenthal et al, 2003;Linden et al, 1999;Menon et al, 1997;Opitz et al, 1999) or event-related magnetic fields (Siedenberg et al, 1996) to the early ERP components observed in oddball paradigms. A simultaneous EEG/MEG study found that N1 waveforms during two-tone auditory oddball rare target detection was similar in both ERP and MEG, and were localized to temporal lobe regions (Siedenberg et al, 1996).…”

Section: Discussionmentioning

confidence: 90%

The hemodynamics of oddball processing during single-tone and two-tone target detection tasks

Stevens

Laurens

Liddle

et al. 2006

International Journal of Psychophysiology

View full text Add to dashboard Cite

Event-related potential (ERP) studies have shown that the neural systems engaged during performance of oddball tasks are sensitive to contextual manipulations, such as the number of stimulus classes. Some ERP components (i.e., N1) are modulated by the number of stimulus types, while others (i.e., P3) are not greatly affected. However, little is known about how these contextual manipulations affect the hemodynamics underlying oddball processing. The purpose of this study was to examine the hemodynamic correlates of target stimulus processing in singletone (targets alone) and two-tone (targets and standard tones) auditory oddball tasks. The primary hypothesis was that processing of salient stimuli in both contextual conditions would engage the same spatially distributed cortical and subcortical networks observed in previous oddball fMRI studies. Results were consistent with this hypothesis and suggest that the brain engages many potentially useful brain regions during salient stimulus processing despite the low probability that said regions are necessary for task performance, which likely reflects a form of "adaptive reflexive processing." Results also were consistent with ERP data that shows the N1 is larger for single-tone tasks by showing greater amplitude of hemodynamic response for singletone targets, relative to two tone targets, in bilateral temporal cortex and bilateral inferior lateral frontal cortex. The results are discussed as they relate to the understanding of neurocognitive function pertaining to contextual manipulations in general, and orienting processes in particular. Keywords ORIENTING; MAGNETIC RESONANCE IMAGING; BRAIN; PSYCHOLOGY; COGNITIONThe neural systems underlying processing of low probability target stimuli have been studied for over four decades. The impact of salient stimulus processing on brain electrical activity was first described by Sutton et al. (1965), who demonstrated that infrequently-presented taskrelevant stimuli ("oddballs") produce a sequence of time-locked electrical components, the NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript most prominent of which is a large positive potential that peaks approximately 300 milliseconds following the stimulus onset. This late event-related potential (ERP), termed the P300 or P3, is thought to reflect stimulus evaluation/categorization, and cognitive processes necessary to update mental models of context within working memory (Donchin & Coles, 1988). Since Sutton et al's seminal study, numerous reports have been published that detail how contextual manipulations in the oddball paradigm (e.g., manipulations of stimulus probability, inter-trial interval, sensory modality, etc.) modulate the latency, amplitude or topographic distribution of the P3 .One contextual manipulation to the oddball task is to alter the number of stimulus classes presented within the task. Researchers most commonly use oddball tasks having either twostimulus classes (low probability targets juxtaposed with frequent standards) or ...

show abstract

Section: Discussionmentioning

confidence: 90%

The hemodynamics of oddball processing during single-tone and two-tone target detection tasks

Stevens

Laurens

Liddle

et al. 2006

International Journal of Psychophysiology

View full text Add to dashboard Cite

show abstract

“…Previous studies have shown that the location of the neural MMN sources depends on the nature of the auditory stimuli involved, with prominent generators located in the superior temporal cortex and in particular the planum temporale (Giard et al, 1990;Liebenthal et al, 2003;Molholm et al, 2005). A recent functional magnetic resonance imaging (fMRI) study indicated that the neural processing of language-specific phonotactic constraints involves the left superior temporal and the left anterior supramarginal gyri (Jacquemot et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Auditory cortical tuning to statistical regularities in phonology

Bonte

Mitterer

Zellagui

et al. 2005

Clinical Neurophysiology

124

View full text Add to dashboard Cite

Objective: Ample behavioral evidence suggests that distributional properties of the language environment influence the processing of speech. Yet, how these characteristics are reflected in neural processes remains largely unknown. The present ERP study investigates neurophysiological correlates of phonotactic probability: the distributional frequency of phoneme combinations. Methods: We employed an ERP measure indicative of experience-dependent auditory memory traces, the mismatch negativity (MMN). We presented pairs of non-words that differed by the degree of phonotactic probability in a modified passive oddball design that minimizes the contribution of acoustic processes. Results: In Experiment 1 the non-word with high phonotactic probability (notsel) elicited a significantly enhanced MMN as compared to the non-word with low phonotactic probability (notkel). In Experiment 2 this finding was replicated with a non-word pair with a smaller acoustic difference (notsel-notfel). An MMN enhancement was not observed in a third acoustic control experiment with stimuli having comparable phonotactic probability (so-fo). Conclusions: Our data suggest that auditory cortical responses to phoneme clusters are modulated by statistical regularities of phoneme combinations. Significance: This study indicates that the language environment is relevant in shaping the neural processing of speech. Furthermore, it provides a potentially useful design for investigating implicit phonological processing in children with anomalous language functions like dyslexia.

show abstract

“…A likely candidate for such a miss is the auditory onset response and the subsequent low-level orienting/change detection processes. Although being expressed in the N1-ERP (Naatanen, et al, 1987;Woods, 1995) and in bilateral temporal fMRI activation (Kiehl, et al, 2005;Liebenthal, et al, 2003;Linden, et al, 1999) this process did not support a significant correlation between the modalities (cf. Eichele, et al, 2005).…”

Section: Introductionmentioning

confidence: 97%

Unmixing concurrent EEG-fMRI with parallel independent component analysis

Eichele

Calhoun

Moosmann

et al. 2008

International Journal of Psychophysiology

104

View full text Add to dashboard Cite

Concurrent event-related EEG-fMRI recordings pick up volume-conducted and hemodynamically convoluted signals from latent neural sources that are spatially and temporally mixed across the brain, i.e. the observed data in both modalities represent multiple, simultaneously active, regionally overlapping neuronal mass responses. This mixing process decreases the sensitivity of voxel-byvoxel prediction of hemodynamic activation by the EEG when multiple sources contribute to either the predictor and/or the response variables. In order to address this problem, we used independent component analysis (ICA) to recover maps from the fMRI and timecourses from the EEG, and matched these components across the modalities by correlating their trial-to-trial modulation. The analysis was implemented as a group-level ICA that extracts a single set of components from the data and directly allows for population inferences about consistently expressed function-relevant spatiotemporal responses. We illustrate the utility of this method by extracting a previously undetected but relevant EEG-fMRI component from a concurrent auditory target detection experiment. §Corresponding Author:

show abstract

Simultaneous ERP and fMRI of the auditory cortex in a passive oddball paradigm

Cited by 161 publications

References 33 publications

The hemodynamics of oddball processing during single-tone and two-tone target detection tasks

The hemodynamics of oddball processing during single-tone and two-tone target detection tasks

Auditory cortical tuning to statistical regularities in phonology

Unmixing concurrent EEG-fMRI with parallel independent component analysis

Contact Info

Product

Resources

About