Simultaneous determination of fluvoxamine isomers and quetiapine in human plasma by means of high-performance liquid chromatography

Saracino, Maria Addolorata; Mercolini, Laura; Flotta, G.; Albers, Lawrence J.; Merli, Roberto; Raggi, Maria Augusta

doi:10.1016/j.jchromb.2006.06.001

Cited by 62 publications

(33 citation statements)

References 25 publications

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“…Generally speaking, almost all of the antipsychotics on the market have UV absorption. HPLC-UV methods are very popular for the determination of antipsychotics in biological samples (Titier et al, 2002(Titier et al, , 2003Llerena et al, 2003;Dusci et al, 2002;Aboul-Enein et al, 2006;Pistos and Stewart, 2003;Midha et al, 1981;Mosier et al, 2003;Garay Garcia et al, 2003;Chung et al, 1993;Olesen and Poulsen, 1993;Gupta, 1995;Saracino et al, 2006b;Hasselstrom and Linnet, 2003;Shimokawa et al, 2005;Sachse et al, 2006;Shen et al, 2002;Frahnert et al, 2003;Zhang et al, 2007c;Mercolini et al, 2007). In addition, Lara et al (2005) and Ho et al (2004) described CZE-UV methods for the quantitation of antipsychotics in biological samples.…”

Section: Ultraviolet Detectionmentioning

confidence: 99%

Bioanalytical methods for the determination of antipsychotic drugs

Zhang

Terry

Bartlett

2008

Biomedical Chromatography

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Antipsychotic drugs are popular for the treatment of schizophrenia and other psychoses. In general, antipsychotics are administered in oral doses of only a few milligrams per day and they are widely metabolized in the body. Therefore, the concentration of these drugs in plasma is very low (pg-ng/mL levels). In addition, therapeutic drug monitoring (TDM) of antipsychotic drugs has proven to be of notable value for determining poor compliance of patients and addressing the challenges associated with considerable genetic variability in their metabolism. Thus, in order to conduct pharmacology and toxicology studies and clinical TDM of antipsychotics, as well as address the challenges associated with polypharmacy and drug metabolism, highly sensitive, selective and accurate bioanalytical methods are essential. The most recent studies on the determination of antipsychotics will be reviewed, including separation techniques, sample pretreatment, detectors and validation.

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Section: Ultraviolet Detectionmentioning

confidence: 99%

Bioanalytical methods for the determination of antipsychotic drugs

Zhang

Terry

Bartlett

2008

Biomedical Chromatography

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“…Several methods for the determination of atypical antipsychotic drugs using high-performance liquid chromatography (HPLC) [6], LC/MS and LC/MS/MS have already been reported [7] [8] [9] [10] [11]. However, the simultaneous determination of eight of them (risperidone, olanzapine, quetiapine, clozapine, ziprasidone, perospirone, aripiprazole and blonanserin) using LC/MS/MS has not been seen.…”

Section: Introductionmentioning

confidence: 99%

Sensitive Liquid Chromatography/Tandem Mass Spectrometry Method for the Simultaneous Determination of Risperidone, Olanzapine, Quetiapine, Clozapine, Ziprasidone, Perospirone, Aripiprazole and Blonanserin in Human Serum

Tonooka¹,

Yoshida²,

Tomobe³

et al. 2018

AJAC

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The sensitive method for the simultaneous determination of eight atypical antipsychotic drugs (risperidone, olanzapine, quetiapine, clozapine, ziprasidone, perospirone, aripiprazole and blonanserin) in human serum has been developed based on a high-performance liquid chromatography-tandem mass spectrometry (LC/MS/MS) with electrospray ionization (ESI). The chromatographic separation was performed on a Mightysil-RP-18 MS column (2.0 mm × 150 mm, particle size 3 µm). The mobile phase consisted of 10 mM formic ammonium buffer (pH 6.0) and acetonitrile and was delivered at a flow rate of 0.20 mL/min. The triple quadrupole mass spectrometer was operated in positive ion mode, and multiple reaction monitoring was used for drug quantification. Solid-phase extraction of the eight antipsychotic drugs added to the human serum was performed with an Oasis ® HLB extraction cartridges column. The method was linear for the investigated drugs over the concentration range of 20 -100 ng/mL. The recoveries of these drugs were in the range of 81.3% -140%. The intraday and inter day standard deviation (SD) values for all analytes were <0.10. Therefore, the selectivity, accuracy and precision of this method are sufficient for clinical and forensic studies. This simultaneous screening method will be also applicable to analyze other atypical antipsychotic drugs.

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“…Only some high-performance liquid chromatography (HPLC) methods [8][9][10][11][12] and voltammetric method [13] have been developed for determination of QTI in biological fluids. These described methods use solid-phase extraction (SPE) or liquid-liquid extraction (LLE) to deal with plasma samples with a lower limit of quantification.…”

Section: Introductionmentioning

confidence: 99%

Selective RP-HPLC method for determination of quetiapine in presence of coadministered drugs: Application for long-term stability study of quetiapine in whole blood

Youssef

Abdine

Barary

et al. 2016

Acta Chromatographica

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Summary. Incidence of suicidal attempts presents an explanation for the high prevalence of quetiapine (QTI) in forensic cases. Thus, the interpretation of its concentrations in biological specimens is needed, but in forensic toxicology, potential postmortem changes such as instability of the target drugs should be taken in consideration. Highperformance liquid chromatography (HPLC) method has been developed for determination of QTI. This method was based on reversed phase (RP)-HPLC separation of QTI on a C-18 column (150 mm × 4.6 mm, 5 μm) with elution system of acetonitrile-methanol-0.025 M phosphate buffer (pH 2.5), containing 1 mL TEA in each 250 mL, in a ratio of 40:30:30%, v/v, at the flow rate of 1.2 mL min −1 using mirtazapine as internal standard (IS). The proposed method was applied to the determination of QTI in plasma in presence of coadministered drugs. The application of the proposed method was extended for long-term stability study of two different concentration levels of QTI in the whole blood.

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Simultaneous determination of fluvoxamine isomers and quetiapine in human plasma by means of high-performance liquid chromatography

Cited by 62 publications

References 25 publications

Bioanalytical methods for the determination of antipsychotic drugs

Bioanalytical methods for the determination of antipsychotic drugs

Sensitive Liquid Chromatography/Tandem Mass Spectrometry Method for the Simultaneous Determination of Risperidone, Olanzapine, Quetiapine, Clozapine, Ziprasidone, Perospirone, Aripiprazole and Blonanserin in Human Serum

Selective RP-HPLC method for determination of quetiapine in presence of coadministered drugs: Application for long-term stability study of quetiapine in whole blood

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