Simultaneous analysis method for GHB, ketamine, norketamine, phenobarbital, thiopental, zolpidem, zopiclone and phenytoin in urine, using C18 poroshell column

Evaluation of three methods for betanin quantification in fruits from cacti

“…The literature suggest that accuracy should be less than 15% [20] , the analysis of garambullo sample with HPLC, chico sample with SEC and HPLC were more than 15%. HorRat is an assessment of the acceptability of the intermediate precision values, and it has been applied as one of the acceptability criteria for many adopted chemical analysis methods [21] . The acceptability range for HorRat is in a range of 0.5 to 2 [15] .…”

Interpol review of controlled substances 2016–2019

“…Liquid Chromatography: 2016 method for simultaneous analysis of GHB, ketamine, norketamine, phenobarbital, thiopental, zolpidem, zopiclone and phenytoin (an anticonvulsant and antiepileptic drug) with LC-MS/MS [ 1559 ]; Enantiomeric separation of citalopram was developed using a reversed phase HPLC with sulfobutylether-beta-cyclodextrin as a chiral mobile phase additive [ 1560 ]; multivariate curve resolution-alternating least squares analysis of HRLC-MS data [ 1561 ]; beta-cyclodextrin-based open-tubular capillary electrochromatography column and application for Enantioseparation of zopiclone, chlorphenamine maleate, brompheniramine maleate, dioxopromethazine hydrochloride, carvedilol, homatropine hydrobromide, homatropine methylbromide, venlafaxine, sibutramine hydrochloride and terbutaline sulfate [ 1562 ]; analysis of psychotropic drugs using an ultra-high-speed HPLC [ 1563 ]; 2017 Response surface methodology based on central composite design accompanied by multivariate curve resolution to model gradient hydrophilic interaction liquid chromatography for separation of five major opium alkaloids [ 1564 ]; 2018 LC/MS/MS for detection of prohibited substances in exhaled breath [ 1565 ]; HPLC-DAD method to characterize thirteen common colorants from five key classes of dyes found in illicit ecstasy and diazepam tablets [ 1566 ]; 2019 reversed-phase liquid chromatography by using functionalized multi-walled carbon nanotubes for separation and analysis of barbiturates, steroid hormones and alkaloids [ 1567 ].…”

A Fast and Validated High Throughput Bar Adsorptive Microextraction (HT-BAµE) Method for the Determination of Ketamine and Norketamine in Urine Samples

“…The samples were vortexed for a few seconds, centrifuged for 10 min at 4500 rpm (Hermle Z 300, Germany) and the supernatants were collected. Afterwards, an acid hydrolysis was performed in order to obtain free KET or NKET from its corresponding conjugates, in accordance with the literature [15]. Therefore, 500 µL of the urine supernatants were pipetted into the microextraction vials already present in the HT-BAµE apparatus and 150 µL of HCOOH 10% (v/v) were added.…”

“…As a result of this, it was initially abused by medical personnel and gradually became popular among young users at dance and rave parties [3]. In fact, the total quantity of KET seized worldwide increased from an annual average of 3 tons in the period 1998-2008 to 10 tons in the period 2009-2014 and 15 between 2015 and 2017 [4]. In humans, KET is metabolized in the liver by the microsomal cytochrome P450 system.…”

“…Several analytical methods have been described in the literature for the determination of KET or NKET in urine samples, mostly using high performance liquid chromatography with ultraviolet/visible detection (HPLC-UV) [9], gas chromatography (GC) coupled to either flame ionization detector (FID) [10], mass spectrometry (MS) [3,7,11], Tandem mass spectrometry (MS/MS) [12] or even liquid chromatography (LC) coupled to MS [7,8] or MS/MS [13,14]. Sample preparation techniques used in combination with these chromatographic or hyphenated systems include conventional liquid-liquid extraction (LLE) [8] or solid-phase extraction (SPE) [7,14,15], but also miniaturized techniques such as solid-phase microextraction (SPME) [16], stir bar sorptive extraction [9], hollow-fiber liquid-phase microextraction [3,10] or microextraction by packed sorbent (MEPS) [12]. However, the preparation and manipulation of these techniques are tiresome, and the number of possible simultaneous microextractions are very limited, especially when routine work is involved.…”