Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2011.12.042 View full text
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Charles M. Grill, Stefanie Abel, Markus Juza, Elke Huthmann

Abstract: Simulated moving bed (SMB) chromatography is a complicated process that generally requires modeling to determine starting conditions. Typically one uses the triangle theory to arrive at these starting conditions. The most common adsorption isotherm model used to construct the triangle is the Langmuir isotherm or an isotherm derived from the Langmuir isotherm. Often, modeling software supplied by the SMB manufacturer is used to determine the Langmuirian isotherm parameters. This proprietary approach, while succ…

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