Simple and sensitive spectrophotometric methods for the analysis of mesalamine in bulk and tablet dosage forms

Abstract

Recebido em 26/10/10; aceito em 30/1/11; publicado na web em 1/4/11 Three simple, sensitive, economical and reproducible spectrophotometric methods (A, B and C) are described for determination of mesalamine in pure drug as well as in tablet dosage forms. Method A is based on the reduction of tungstate and/or molybdate in Folin Ciocalteu's reagent; method B describes the reaction between the diazotized drug and α-naphthol and method C is based on the reaction of the drug with vanillin, in acidic medium. Under optimum conditions, mesalamine could be quantified in the concentration ranges, 1-30, 1-15 and 2-30 µg mL -1 by method A, B and C, respectively. All the methods have been applied to the determination of mesalamine in tablet dosage forms. Results of analysis are validated statistically.

Combined exercise training decreases blood pressure in OLDER women with NOS3 polymorphism providing changes in differentially methylated regions (DMRs)

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Diazotizasyon ve Kuplaj Reaksiyonu ile Saf Form ve Farmasötik formülasyonlarda Mesalazin'in spektrofotometrik tayini

“…In the literature review, various analytical methods for assaying MZN were used, including voltammetric [5][6], spectrofluorometric [7], HPLC [8], flowinjection analysis method [9] Also, charge transfer complex reactions [10] and oxidative coupling reactions [11], in addition to spectroscopic methods [12][13][14][15][16][17][18], the aim of this work is to develop the sensitivity of a method for the determination of MZN as pure and pharmaceutical formulations based on the diazotization and coupling reaction of MZN with 2,7-Dihydroxynaphthalene (DHNP) in an alkaline medium from sodium carbonate solution, forming an orangered azo dye with a maximum absorbance of 501 nm.…”

Electrochemical determination of mesalazine by using graphene oxide coated with a molecularly imprinted sol–gel

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