Simple and selective analysis of different antibiotics in milk using molecularly imprinted polymers: a review

Abstract

The frequent, sometimes illegal, use of antibiotics for therapeutic and prophylactic purposes in dairy cattle management may cause residues in milk. Because of problems concerning bacterial resistance or allergies in consumers, monitoring of residues is required. In spite of the huge development of analytical instrumentation during recent years, sample preparation is still a bottleneck of the analytical process. In this regard, efforts have been directed towards improving selectivity during extraction and clean-up of samples. Compared to traditional sorbents, molecularly imprinted polymers (MIPs) are excellent materials to provide selectivity for sample pretreatment. This review presents the application of MIPs as effective sorbents for separation, clean-up, pre-concentration and analysis of different antibiotics in milk.

Molecularly imprinted polymer film grafted from porous silica for efficient enrichment of steroid hormones in water samples

“…In this study, six types of different MIPs have been successfully developed for extraction of steroid hormones in water samples. The main advantages of MIPs compared to traditional C18 SPE cartridges are high efficiency, selectivity, good reusability, and low cost of production, so MISPE has found a wide range of applications in analytical chemistry . The recoveries obtained in this study were in the range of 84.4–98.6% for MIP‐1, 78.7–98.5% for MIP‐2, 90.1–99.6% for MIP‐3, 84.3–99.7% for MIP‐4, 84.8–99.5% for MIP‐5, and 84.7–101.3% for MIP‐6, and the precision values were 0.1–0.9%.…”

Molecularly imprinted polymersviareversible addition–fragmentation chain-transfer synthesis in sensing and environmental applications

“…4 Analytical instrumentation has been implemented to address this situation by sporadically keeping track of the level of free contaminants in urban systems. 5 However, this approach requires a long time between sampling and quantification, thus making it irrelevant to the real situation. 6,7 The environment is dynamic and complex, and our ability to detect and neutralize pollutants must adapt.…”

Preparation, evaluation, and application of dummy molecularly imprinted polymer for analysis of hesperidin in lime juice

“…In this approach, a dummy template, which possesses analogous structure of target molecule, is used for synthesis of imprinted polymers. Development of molecularly imprinted SPE (MISPE) for preconcentration and clean up stage contains several advantages in comparison with other usual sample preparation methods such as selectivity, speed, convenience, miniaturized organic solvents consumption, and usability in automated analytical methods [20, 21].…”