Simple and fast fabrication of microfluidic paper-based analytical device by contact stamping for multiple-point standard addition assay: Application to direct analysis of urinary creatinine

Mathaweesansurn, Arjnarong; Thongrod, Suthathip; Khongkaew, Putthiporn; Phechkrajang, Chutima; Wilairat, Prapin; Choengchan, Nathawut

doi:10.1016/j.talanta.2019.120675

Cited by 41 publications

(25 citation statements)

References 39 publications

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“…Urine has many advantages as a biomedical sample, including natural abundance, noninvasiveness and biological richness. Consequently, many microfluidic lab-on-paper platforms for urine analysis and disease detection have been proposed in recent years [100,108,164,165]. Many devices have also been successfully commercialized around the world, including the HiPee S2 smart urine analyzer (Tianjin Guo-Shih Tech.…”

Section: Discussionmentioning

confidence: 99%

“…As a result, the effective treatment period is curtailed, leading to serious lesions and a significant deterioration in quality of life [104]. However, recent research has shown that lab-on-paper platforms provide a feasible means of detecting early-stage kidney disease by evaluating the concentrations of creatinine (Cre) and albumin (Alb) [105][106][107][108][109][110][111], micro-albumin and protein [112][113][114][115][116], and uric acid [117][118][119][120][121][122][123] in urine samples.…”

Section: Creatinine Albumin Protein and Uric Acid Analysismentioning

confidence: 99%

“…The device achieved a wide linear detection range of 0.2 to 1 mM with limits of detection and quantitation of 0.08 and 0.26 mM, respectively. Mathaweesansurn et al [108] presented a contact-imprinted lab-on-paper device for the multi-point determination of Cre in human urine. As shown in Figure 3a, a single-step embossing method was first performed using a rubber stamp to fabricate eight individual hydrophobic barrier structure patterns on the lab-on-paper platform for multi-point standard analysis.…”

Section: Creatinine Albumin Protein and Uric Acid Analysismentioning

confidence: 99%

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Lab-on-Paper Devices for Diagnosis of Human Diseases Using Urine Samples—A Review

et al. 2021

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In recent years, microfluidic lab-on-paper devices have emerged as a rapid and low-cost alternative to traditional laboratory tests. Additionally, they were widely considered as a promising solution for point-of-care testing (POCT) at home or regions that lack medical infrastructure and resources. This review describes important advances in microfluidic lab-on-paper diagnostics for human health monitoring and disease diagnosis over the past five years. The review commenced by explaining the choice of paper, fabrication methods, and detection techniques to realize microfluidic lab-on-paper devices. Then, the sample pretreatment procedure used to improve the detection performance of lab-on-paper devices was introduced. Furthermore, an in-depth review of lab-on-paper devices for disease measurement based on an analysis of urine samples was presented. The review concludes with the potential challenges that the future development of commercial microfluidic lab-on-paper platforms for human disease detection would face.

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Section: Discussionmentioning

confidence: 99%

Section: Creatinine Albumin Protein and Uric Acid Analysismentioning

confidence: 99%

Section: Creatinine Albumin Protein and Uric Acid Analysismentioning

confidence: 99%

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Lab-on-Paper Devices for Diagnosis of Human Diseases Using Urine Samples—A Review

et al. 2021

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“…These methods have gained interest for a variety of applications, for example environmental monitoring, food safety inspection, pharmaceutical analysis, and clinical diagnosis. Paper-based devices can be created with distinct hydrophilic and hydrophobic zones on the paper using photolithography, 11,12 plasma treatment, 13 wax printing, 14–16 screen-printing, 17–19 plotting, 20–22 inkjet printing, 23–26 stamping, 27,28 and other methods. Unfortunately, photolithography, plasma-treatment, wax printing, inkjet printing, and plotting have some inherent limitations.…”

Section: Introductionmentioning

confidence: 99%

A simple epoxy resin screen-printed paper-based analytical device for detection of phosphate in soil

Thongkam

Hemavibool

2022

Anal. Methods

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“…Recent studies have shown that paper-based devices provide a viable method for detecting early CKD by assessing the concentration of ALB, MAU (microalbuminuria), CRE, or ACR in urine samples [ 4 , 19 , 46 , 47 , 48 , 49 , 50 ]. For example, Cai et al [ 46 ] presented a field amplification paper-based device for sensitive colorimetric detection of MAU in human urine.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Sliding Paper-Based Device for Point-of-Care Determination of Albumin-to-Creatine Ratio in Human Urine

et al. 2022

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A novel assay platform consisting of a microfluidic sliding double-track paper-based chip and a hand-held Raspberry Pi detection system is proposed for determining the albumin-to-creatine ratio (ACR) in human urine. It is a clinically important parameter and can be used for the early detection of related diseases, such as renal insufficiency. In the proposed method, the sliding layer of the microchip is applied and the sample diffuses through two parallel filtration channels to the reaction/detection areas of the microchip to complete the detection reaction, which is a simple method well suited for self-diagnosis of ACR index in human urine. The RGB (red, green, and blue) value intensity signals of the reaction complexes in these two reaction zones are analyzed by a Raspberry Pi computer to derive the ACR value (ALB and CRE concentrations). It is shown that the G + B value intensity signal is linearly related to the ALB and CRE concentrations with the correlation coefficients of R2 = 0.9919 and R2 = 0.9923, respectively. It is additionally shown that the ALB and CRE concentration results determined using the proposed method for 23 urine samples were collected from real suffering chronic kidney disease (CKD) patients are in fine agreement with those acquired operating a traditional high-reliability macroscale method. Overall, for point-of-care (POC) CKD diagnosis and monitoring in clinical applications, the results prove that the proposed method offers a convenient, real time, reliable, and low-spending solution for POC CKD diagnosis.

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Simple and fast fabrication of microfluidic paper-based analytical device by contact stamping for multiple-point standard addition assay: Application to direct analysis of urinary creatinine

Cited by 41 publications

References 39 publications

Lab-on-Paper Devices for Diagnosis of Human Diseases Using Urine Samples—A Review

Lab-on-Paper Devices for Diagnosis of Human Diseases Using Urine Samples—A Review

A simple epoxy resin screen-printed paper-based analytical device for detection of phosphate in soil

Microfluidic Sliding Paper-Based Device for Point-of-Care Determination of Albumin-to-Creatine Ratio in Human Urine

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