Similarity and diversity of spontaneous brain activity in functional dyspepsia subtypes

Qi, Rongfeng; Zhao, Shihua; Weng, Yifei; Yang, Yu‐Lin; Zhou, Yifei; Surento, Wesley; Lu, Guang Ming; Wang, Fangyu; Zhang, Long Jiang; Liu, Chang

doi:10.1177/0284185119883391

Cited by 6 publications

(9 citation statements)

References 46 publications

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“…These results also fitted the functional alteration in GM-related studies, such as decreased functional connectivity of insula (Sun et al, 2020); decreased GM density in the middle frontal gyrus, right precentral gyrus, and insula (Zeng et al, 2013); and decreased connectivity between insula and thalamus (Liu et al, 2018). Our former study also found altered amplitude of low-frequency fluctuation in insula and thalamus (Qi et al, 2020). Our results supported that the frontal lobe, insula, and thalamus were the key regions in FD patients.…”

Section: Discussionsupporting

confidence: 88%

Distributed Functional Connectome of White Matter in Patients With Functional Dyspepsia

Weng

Liu

et al. 2021

Front. Hum. Neurosci.

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Purpose: We aimed to find out the distributed functional connectome of white matter in patients with functional dyspepsia (FD).Methods: 20 patients with FD and 24 age- and gender-matched healthy controls were included into the study. The functional connectome of white matter and graph theory were used to these participants. Two-sample t-test was used for the detection the abnormal graph properties in FD. Pearson correlation was used for the relationship between properties and the clinical and neuropshychological information.Results: Patients with FD and healthy controls showed small-world properties in functional connectome of white matter. Compared with healthy controls, the FD group showed decreased global properties (Cp, S, Eglobal, and Elocal). Four pairs of fiber bundles that are connected to the frontal lobe, insula, and thalamus were affected in the FD group. Duration and Pittsburgh Sleep Quality Index positively correlated with the betweenness centrality of white matter regions of interest.Conclusion: FD patients turned to a non-optimized functional organization of WM brain network. Frontal lobe, insula, and thalamus were key regions in brain information exchange of FD. It provided some novel imaging evidences for the mechanism of FD.

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Section: Discussionsupporting

confidence: 88%

Distributed Functional Connectome of White Matter in Patients With Functional Dyspepsia

Weng

Liu

et al. 2021

Front. Hum. Neurosci.

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“…Individual head translations, rotations, and the framewise displacement were calculated, and only one healthy control in this study was found to have excessive head motion. Second, the T1 structural image was co-registered to the functional image, then and then normalized to the standard Montreal Neurological Institute (MNI) space with Exponentiated Lie algebra (DARTEL) as in the study of Qi et al ( 2019 ). Third, the white matter signal and cerebrospinal fluid signal were also regressed out.…”

Section: Methodsmentioning

confidence: 99%

“…ALFF was computed with the same method as described in the previous study (Qi et al, 2019 ). After bandpass filtered (0.01–0.1 Hz) and detrended, the time course was transformed to the frequency domain with Fast Fourier Transform.…”

Section: Methodsmentioning

confidence: 99%

Alterations of Spontaneous Brain Activity in Hemodialysis Patients

Chen

Qiu

et al. 2020

Front. Hum. Neurosci.

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Cognitive impairment is prevalent in hemodialysis end-stage renal disease (ESRD) patients. It might be associated with poor prognosis. Nevertheless, the underlying mechanisms have not been completely clarified. This study explored spontaneous brain activity in ESRD patients on hemodialysis by using the amplitude of low-frequency fluctuation (ALFF). Nineteen ESRD patients on regular hemodialysis were included in this study. Eighteen age-, sex- and education level-matched volunteers were enrolled as the healthy control group. All participants had resting-state functional MRI scanning, neuropsychological tests, and laboratory testing. ALFF was used for assessing intrinsic brain activity. Independent samples t -test was used for obtaining group differences. Spearman correlation analysis was applied to assess the association between ALFF changes, neuropsychological, and clinical indices. Compared to the healthy control group, hemodialysis patients showed decreased ALFF in the precuneus, right angular gyrus/inferior lobule as well as increased ALFF in the left parahippocampus/hippocampus and right precentral/postcentral gyrus. The ALFF abnormalities in these regions were closely associated with hemoglobin levels. Also, increased ALFF in the left parahippocampus/hippocampus showed a negative correlation with the score of long-delayed free recall. Hemodialysis patients had aberrant ALFF in the default mode network (DMN) regions, particularly in the precuneus and parahippocampus/hippocampus, which may be correlated with neuropathological mechanisms involved in hemodialysis.

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“…Non-invasive and high spatial and temporal resolution techniques, such as functional magnetic resonance imaging (fMRI), support brain–gut interaction studies based on human beings. For example, through fMRI techniques, studies have identified changes in brain activity in the medial prefrontal cortex, orbitofrontal cortex, cingulate gyrus, hippocampus, precuneus, and temporal pole in FD patients compared with healthy subjects ( Liu et al, 2013 ; Chen et al, 2018 ; Qi et al, 2020 ). Thus, the Rome criteria have defined FD as a disease with abnormal brain–gut interaction ( Drossman, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

The Role of Medial Prefrontal Cortex in Acupuncture Treatment for Functional Dyspepsia

et al. 2022

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Acupuncture is an effective therapy for functional dyspepsia (FD). However, the efficacy of acupuncture in the treatment of FD varies among individuals in clinical practice. This study aimed to reveal the brain response patterns in acupuncture higher response/lower response FD patients. Firstly, we performed a within-group comparison of brain function activity before and after acupuncture treatment in 115 FD patients and analyzed the correlation between brain function activity changes and clinical improvements. Secondly, 115 subjects were divided into the acupuncture higher response group or the lower response group based on the median clinical improvement values. The changes in functional brain activity after acupuncture treatment were investigated in these two groups, respectively. Finally, the identified brain regions associated with the clinical improvements were set as regions of interest (ROI), and the ROI-to-voxel functional connectivity comparisons were also performed in both groups, respectively. The results demonstrated that the functional activities of the left cerebellum inferior, right middle temporal gyrus, and right medial prefrontal cortex (mPFC) were increased, and the left Heschl and right middle cingulate cortex were decreased in 115 FD patients after acupuncture treatment. The functional connectivity changes of mPFC were correlated with improving the Nepean Dyspepsia Symptom Index. The significant increase in mPFC functional activity was also found in acupuncture higher response FD patients but not in lower response FD patients. The functional connectivity between the mPFC and default mode network (DMN) was significantly diminished in the higher response group but not in the lower response group. In conclusion, this study suggested that modulating the functional activity of the mPFC and its connectivity to the DMN may be one of the important mechanisms of acupuncture for treating FD with a higher response.

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Similarity and diversity of spontaneous brain activity in functional dyspepsia subtypes

Cited by 6 publications

References 46 publications

Distributed Functional Connectome of White Matter in Patients With Functional Dyspepsia

Distributed Functional Connectome of White Matter in Patients With Functional Dyspepsia

Alterations of Spontaneous Brain Activity in Hemodialysis Patients

The Role of Medial Prefrontal Cortex in Acupuncture Treatment for Functional Dyspepsia

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