Similarities between allergen sensitivity patterns of central compartment atopic disease and allergic rhinitis

Tripathi, Siddhant; Ungerer, Heather; Rullan‐Oliver, Bianca; Patel, Tapan D.; Sweis, Auddie M.; Maina, Ivy W.; Kohanski, Michael A.; Palmer, James N.; Adappa, Nithin D.; Bosso, John V.

doi:10.1002/alr.22983

Cited by 6 publications

(3 citation statements)

References 5 publications

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“…Table 4 summarizes the current CCAD studies in adults. [5][6][7][8]14,17,[22][23][24][25][26] We saw most of them were from western countries. CCAD was considered strongly associated with allergy.…”

Section: Discussionmentioning

confidence: 94%

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Clinical characteristics of central compartment atopic disease in Southern China

Nie

Fan

et al. 2022

Int Forum Allergy Rhinol

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Background Central compartment atopic disease (CCAD) is a newly reported subset of chronic rhinosinusitis. It was considered associated with inhalant antigen. However, CCAD in Chinese population is not fully studied yet. Design Prospective cohort study. Objective This study aimed to describe the clinical manifestations of CCAD and compared the following two subtypes: sinonasal polyps and concomitant polypoid disease in the central compartment (CRSwNP/CC) and CRSwNP not otherwise specified (CRSwNP NOS). Also, we compared the clinical manifestations of atopy CCAD and non‐atopy CCAD. Methods We consecutively enrolled CRSwNP patients without prior sinus surgery, and assessed the nasal endoscopy and computed tomography of the paranasal sinuses. Allergy was confirmed by skin or serum testing. Eosinophilic CRSwNP (ECRS) was considered as tissue eosinophils to total inflammatory cells >10%. Results We enrolled a total of 116 patients, including 39 with CCAD, 38 with CRSwNP/CC and 39 with CRSwNP NOS. Atopy was detected in 37.1% of the CCAD group, an incidence showing no significant difference from those in the other two groups (37.1% in the CRSwNP/CC group, 31.0% in the CRSwNP NOS group; p = 0.846). However, the incidence of ECRS in the CCAD group was the highest among the different groups (97.4% in the CCAD group vs. 67.6% in the CRSwNP/CC group vs. 35.1% in the CRSwNP NOS group; p = 0.000). In addition, the incidence of asthma in the CCAD group (33.3%) was significantly higher than that in the CRSwNP NOS group (10.3%), but quite similar to CRSwNP/CC (34.2%). In the subgroup analysis of CCAD, only total serum IgE and sIgE demonstrated significant differences between atopy CCAD and non‐atopy CCAD. Conclusion CCAD in Southern China may associate with asthma and significant eosinophilia, with a lower incidence of systemic allergy based on skin and serum testing.

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Section: Discussionmentioning

confidence: 94%

“…CCAD is a new subset of CRS with NP or polypoid change in the central compartment. Table 4 summarizes the current CCAD studies in adults 5–8,14,17,22–26 . We saw most of them were from western countries.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of central compartment atopic disease in Southern China

Nie

Fan

et al. 2022

Int Forum Allergy Rhinol

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“…Tripathi et al, in 2022, investigated the allergen sensitization profiles of 515 patients with CRS endotypes and AR [21]. The results showed that CCAD had the highest sensitivity to weeds and dust mites and had greater sensitivity to grasses, weeds, cats, dogs, feathers, and other animals than CRSsNP and AERD.…”

Section: Resultsmentioning

confidence: 99%

Central Compartment Atopic Disease as a Pathophysiologically Distinct Subtype of Chronic Rhinosinusitis: A Scoping Review

Davies,

Wu,

Huang

et al. 2023

Sinusitis

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Central compartment atopic disease (CCAD) is a distinct phenotype within chronic rhinosinusitis with nasal polyps (CRSwNP) with a pathophysiology that bridges the gap between allergy and CRSwNP, an association that was previously ambiguous. Understanding this endotype and its link to allergic disease is crucial for improved CCAD management. Using a systematic search and an independent dual-reviewer evaluation and data extraction process, this scoping review examines the clinical features, management options, and treatment outcomes of CCAD. Central compartment (CC) polypoid changes of the MT predominantly correlate with allergic rhinitis, increased septal inflammation, oblique MT orientation, and decreased nasal cavity opacification and Lund–Mackay scores compared to other CRSwNP subtypes. CCAD patients also exhibit higher rates of asthma, allergen sensitization, and hyposmia or anosmia. Surgical outcomes, including revision rate and SNOT-22 improvement, are favorable in CCAD as well. In conclusion, CCAD primarily affects atopic individuals and is managed using endoscopic sinus surgery combined with treating the underlying allergy. Continued research is needed to further refine understanding and develop optimal treatment strategies of this emerging CRS subtype.

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Olfactory Cleft Polyps: REAH or Glandular Hyperplasia

Schertzer

Edwards

DelGaudio

2023

Curr Otorhinolaryngol Rep

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Similarities between allergen sensitivity patterns of central compartment atopic disease and allergic rhinitis

Cited by 6 publications

References 5 publications

Clinical characteristics of central compartment atopic disease in Southern China

Clinical characteristics of central compartment atopic disease in Southern China

Central Compartment Atopic Disease as a Pathophysiologically Distinct Subtype of Chronic Rhinosinusitis: A Scoping Review

Olfactory Cleft Polyps: REAH or Glandular Hyperplasia

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