Simian Virus 40 Is Present in Most United States Human Mesotheliomas, but It Is Rarely Present in Non-Hodgkin's Lymphoma

Immunohistochemical investigation of SV40 large T antigen in Hodgkin and non‐Hodgkin's lymphoma

“…Our data, obtained at the protein level, convincingly confirm the results of MacKenzie et al 4 and Capello et al, 5 but are at variance with those presented by Martini et al, 7 Rizzo et al 8 and David et al 9 Contrary to these studies, we did not find a single positive cell in any of the tissue sections examined. Our results were also negative on frozen sections with both antibodies.…”

“…Instead, Tag was detected in several reactive mononuclear phagocytes present in the biopsy. Rizzo et al, 8 found that SV40 was rarely detected in lymphomas and when present was in low amounts. David et al 9 confirmed these results and concluded that the occasional presence of SV40 in lymphomas was suggestive of an adventitious presence with no role in lymphomagenesis.…”

“…However, a recent report from Japan shows that SV40 DNA sequences are detectable by PCR and in situ hybridization in 19% of cases of diffuse large B-cell lymphoma. 6 Initially, 3 studies from Martini et al, 7 Rizzo et al 8 and David et al 9 concluded that SV40 was infrequently present in lymphomas, when present was found in low amounts and PCR detection was related to the occasional presence of SV40 in some mononuclear phagocytes that are often part of the lymph node biopsy. In addition to low prevalence, immunohistochemical Tag staining performed by Martini et al 7 showed that less than 1% of the tumor cells contained Tag.…”

Retinoblastoma family proteins as key targets of the small DNA virus oncoproteins

“…The natural host of SV40 is the monkey Macacus Rhesus, but even if SV40 usually does not infect humans, accidental injection of SV40 has been reported in people taking the injected form of the polio vaccine between the years 1955 and 1963 (Rizzo et al, 1999;Jasani et al, 2001;Barbanti-Brodano et al, 2004;Dang-Tan et al, 2004). On the other hand, long-term epidemiology studies have failed to detect an increased cancer risk in those individuals likely to have been exposed to the virus mainly by SV40-contaminated polio vaccines (Mortimer et al, 1981;Strickler et al, 1998).…”

SV40 et cancer : un débat à rebondissements

“…Ces divergences ne sont pas limitées au mésothéliome. Pour revenir aux lymphomes non hodgkiniens, un travail récent concluait que SV40 était rarement présent dans ces tumeurs [11]. Une telle inconstance -peut-être liée à une différence géographique -existe en ce qui concerne la présence des séquences de SV40 dans les ostéosarcomes [12].…”