Silymarin prevents adriamycin-induced cardiotoxicity and nephrotoxicity in rats

El-Shitany, Nagla A.; El-Haggar, Sahar Mohamed; El-desoky, Karema

doi:10.1016/j.fct.2008.03.033

Cited by 135 publications

(118 citation statements)

References 42 publications

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“…Furthermore, microalbuminuria was considered an initial sign of renal damage, which predicts proteinuria in hyperglycemic status (33,34). So, we used ELISA technique for measuring LDH and microalbuminuria, two markers that could not be measured by dipstick method, and were also proven to be reliable and robust for the detection of early renal damage to assess the severity of envenomation in rats (35). Our results expressed that subcutaneous injection induced significant increase in urinary LDH enzyme and microalbuminuria after 24 hours.…”

Section: Discussionmentioning

confidence: 78%

In vivo pharmacological study on the effectiveness of available polyclonal antivenom against Hemiscorpius lepturus venom

Jalali¹,

Pipelzadeh²,

Seyedian³

et al. 2011

J. Venom. Anim. Toxins incl. Trop. Dis

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Abstract:The available Razi Institute antivenom is still, empirically, used by intramuscular (IM) administration for the treatment of scorpion stings in humans by six medically dangerous species including Hemiscorpius lepturus (H. lepturus). The aim of this study was to assess the neutralizing ability and effectiveness of the antivenom in inhibiting hemoglobinuria, biochemical changes, increased microalbuminuria and urinary lactate dehydrogenase (LDH) following H. lepturus sting. Simultaneous intramuscular administration of 10 μL and 100 μL of antivenom, after 24 hours, had no significant preventive effect on the extent and degree of hemoglobinuria or proteinuria produced in venom-treated rats. After IM administration of antivenom, no significant changes in decreased red blood cell (RBC) count and hemoglobin were observed. Immediate intramuscular administration of 10 µL of antivenom had no significant effects on both LDH and microalbuminuria. The present findings did not present correlation with clinical signs. Therefore, to fully assess the efficacy of the available antivenom and make appropriate recommendations, more in vivo or in vitro investigations including antigen-antibody interaction, enzymatic analysis and route-dependent administration are required.

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Section: Discussionmentioning

confidence: 78%

In vivo pharmacological study on the effectiveness of available polyclonal antivenom against Hemiscorpius lepturus venom

Jalali¹,

Pipelzadeh²,

Seyedian³

et al. 2011

J. Venom. Anim. Toxins incl. Trop. Dis

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show abstract

“…Several experimental studies have also highlighted the renoprotective properties of SLY against nephrotoxicity induced by different drugs such as cisplatin, 27 doxorubicin, 28 gentamicin, 29 cyclosporine 37 and chemicals such as arsenic, 38 manganese. 39 Similarly, mild nephroprotective action of SLY against MTX-induced renal injury was determined in the present study.…”

Section: Discussionmentioning

confidence: 99%

Effects of silymarin on methotrexate-induced nephrotoxicity in rats

Dabak

Kocaman

2015

Renal Failure

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Methotrexate (MTX) is widely used in the treatment of various malignancies and nononcological diseases but its use has been limited by its nephrotoxicity. Silymarin (SLY), a natural flavonoid, has been reported to have antioxidant, anti-inflammatory and anti-apoptotic effects. This study was carried out to determine whether SLY exerts a protective effect against MTX-induced nephrotoxicity. Rats were divided into six groups: Group 1 (saline, i.p., single injection), Group 2 (0.5% carboxymethyl cellulose (CMC), by gavage once daily for five consecutive days), Group 3 (SLY, 300 mg/kg per day, i.p. for five consecutive days), Group 4 (MTX, 20 mg/kg, i.p., single injection), Group 5 (MTX + CMC similarly as groups 2 and 4) and Group 6 (MTX + CMC + SLY similarly as groups 2, 3 and 4). Histopathologic alterations including apoptotic changes of the kidney were evaluated. MTX injection exhibited dilated Bowman's space, inflammatory cell infiltration, glomerular and peritubular vascular congestion and swelling of renal tubular epithelium cells. Apoptotic cell death was also markedly increased in renal tubules after MTX administration. SLY treatment resulted in statistically significant amelioration in the histological alterations and reduced the number of TUNEL-positive cells as compared with the MTX treated rats (p50.05). In conclusion, SLY treatment leads to a reduction on MTX-induced renal damage in rats. Since SLY is safe and acceptable for human consumption, further studies to define the exact mechanism of the protecting effect of SLY on MTX-induced nephrotoxicity and the optimum dosage of this compound would be useful.

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“…Several investigations have concluded the efficacy of ALA treatment in the prevention of pathologic conditions mediated by oxidative stress (Castro et al, 2013). Silymarin (SIL) is an extract of the milk thistle (Silybum marianum) and it is considered as a standard supportive drug exhibiting a potent hepatoprotective activity for hepatic diseases of various causes through its antioxidant activity, stimulates protein synthesis, affects lipid metabolism, and stabilizes membrane phospholipids (Nencini et al, 2007 andEl-Shitany et al, 2008). Thus, the current investigation was designed to evaluate the hepatoprotective efficacy of both ALA and SIL against TAA-induced hepatotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Potential Ameliorative Effects of Alpha Lipoic Acid and Silymarin on Thioacetamide-Induced Hepatic Damage in Rats

Salama¹,

Oda²,

Khafaga³

et al. 2017

AJVS

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Key words:liver, thioacetamide, silymarin, alpha lipoic acid, rats.The present study was designed to study the ameliorative role of alpha lipoic acid (ALA) and silymarin (SIL) against thioacetamide (TAA)-induced hepatic damage. Sixty male albino rats were randomly separated into 6 groups (n=10); control group, TAA-treated group: received intraperitoneal injection of TAA 250 mg/kg bwt/day three times a week, ALAtreated group: received ALA 100 mg/kg bwt/day) orally three times a week, SIL-treated group: received SIL 100 mg/kg bwt/day orally three times a week, TAA+ALA-treated group, and TAA+SIL-treated group at the same previous doses and routes for ten weeks. Results showed that TAA induced a significant elevation in total and direct bilirubin, total cholesterol and triglycerides levels and serum liver enzymes after four and ten weeks of the treatments. While the serum levels of total proteins, albumin and high density lipoproteincholesterol revealed a significant decrease. TAA injection resulted in an increase in the hepatic lipid peroxidation and decreased levels of antioxidant biomarker. Histopathologically, TAA revealed marked degenerative, necrotic and fibrotic alterations in the liver, particularly during ten weeks post-treatment. ALA and SIL-treatment ameliorated TAA-induced oxidative damage, alterations in the liver function tests and liver histopathology. However, ALA demonstrated better hepatic protection against TAAinduced liver damage as compared to SIL. The study clearly concluded that ALA has more powerful antioxidant properties than SIL.

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Silymarin prevents adriamycin-induced cardiotoxicity and nephrotoxicity in rats

Cited by 135 publications

References 42 publications

In vivo pharmacological study on the effectiveness of available polyclonal antivenom against Hemiscorpius lepturus venom

In vivo pharmacological study on the effectiveness of available polyclonal antivenom against Hemiscorpius lepturus venom

Effects of silymarin on methotrexate-induced nephrotoxicity in rats

Potential Ameliorative Effects of Alpha Lipoic Acid and Silymarin on Thioacetamide-Induced Hepatic Damage in Rats

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