Silymarin Accelerates Liver Regeneration after Partial Hepatectomy

Wu, Jia; Tsai, Chin Chuan; Yeh, Yu Lan; Lin, Chien Chung; Day, Cecilia Hsuan; Shen, Chia Yao; Padma, Viswanadha Vijaya; Pan, Lung Fa; Huang, Chih Yang

doi:10.1155/2015/603529

Cited by 21 publications

(16 citation statements)

References 35 publications

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“…Silymarin has very strong antioxidant activity which can protect liver from both acute and chronic toxicity and injury (Gillessen et al 2014;Abdel-Moneim et al 2015;Luangchosiri et al 2015;Wu et al 2015). Also, silymarin can suppress various inflammatory responses by suppressing NF-jB pathway.…”

Section: Introductionmentioning

confidence: 99%

Silymarin improved diet-induced liver damage and insulin resistance by decreasing inflammation in mice

Guo

Wang

et al. 2016

Pharmaceutical Biology

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Context: Silymarin is the main flavonoid extracted from milk thistle, which has been used to treat liver diseases. Objective: The in vivo effect of silymarin on HFD-induced insulin resistance and fatty liver in mice was studied. Materials and methods: Male C57BL/6 mice were fed with high-fat diet (HFD) to induce obesity and insulin resistance and treated with 30, 60 mg/kg silymarin for 18 days. Food intake, body weight and the content/histology of epididymal fat and liver tissue were examined; the content of lipids, AST, ALT and inflammatory cytokines in serum were estimated. Results: Administration of silymarin caused bodyweight loss in diet induced obesity (DIO) mice (HFD group: 47.7 g, 60 mg/kg group: 43.0 g) while the food intake remain unchanged. Silymarin (60 mg/kg) significantly reduced the epididymal fat mass (from 1.75 g to 1.12 g). Elevated plasma lipids (TC 6.1 mM, TG 1.3 mM, LDL 1.2 mM) in DIO mice were all suppressed by silymarin (TC 4.5 mM, TG 0.89 mM, LDL 0.9 mM), as well as insulin (5.1 ng/ml in HFD group to 2.0 ng/ml (60 mg/kg silymarin). Examination of cytokine levels (TNF-a, IL-1b and IL-6) in each group proved that silymarin treatment significantly decreased inflammation in DIO mice. Finally, silymarin effectively protected liver from HFD-induced injury as evidenced by decreasing histological damage and reducing ALT and AST levels, as follows: ALT; 47.4 U/L in HFD group to 28.4 U/L (60 mg/kg silymarin); AST; 150.1 U/L in HFD group to 88.1 U/L (60 mg/kg silymarin) in serum. Discussion and conclusion: Our results suggested that silymarin-induced alleviation of inflammatory response could be a mechanism responsible for its benefits against liver damage and insulin resistance. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Silymarin improved diet-induced liver damage and insulin resistance by decreasing inflammation in mice

Guo

Wang

et al. 2016

Pharmaceutical Biology

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“…Liver regeneration evolved presumably to protect wild animals from catastrophic liver loss caused by toxins or tissue injury (Wu et al 2015). Lactulose administration accelerates post hepatectomized liver regeneration in rats by inducing hydrogen, which may result from attenuation of the oxidative stress response and excessive inflammatory response (Yu et al 2015).…”

Section: Introductionmentioning

confidence: 99%

“…But in case of silymarin, Wu and Tsai et al have stated that silymarin plays a crucial role in accelerated liver regeneration after Partial hepatectomy. It accelerates the cell cycle in the G1 to S phases (Wu et al 2015). In the D r a f t same time Cetinkunar and Tokgoz et al demonstrated that silymarin does not contributed to proliferative regeneration of the liver-which has very important metabolic functions -after partial hepatectomy; instead it will decrease serum levels of transaminases (Cetinkunar et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Effects of lactulose and silymarin on liver enzymes in cirrhotic rats

Pour

Mirazi

Alaei

et al. 2017

Can. J. Physiol. Pharmacol.

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Silymarin, a mixture of antihepatotoxic flavonolignans used in the treatment of liver diseases, and lactulose, a nonabsorbable synthetic disaccharide, were investigated to analyze their probable synergic and healing effects in a hepatic cirrhotic rat model. Liver damage was induced by the administration and subsequent withdrawal of thioacetamide. The significant decrease in liver enzymes and malondialdehyde levels confirmed the curative effects of silymarin and lactulose. In the silymarin + lactulose group, liver enzyme and malondialdehyde levels were significantly reduced compared with those in the thioacetamide group. All treatments led to liver regeneration and triggered enhanced regeneration. Silymarin and lactulose alone or in combination have potent curative effects and reduce thioacetamide-induced liver damage.

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“…Studies focused on understanding the liver regeneration and on new pharmacological developments are important. Studies on animals have demonstrated the effect of agents, such as silymarin (2) , bicyclol (3) , curcumin (4) , and amiodarone (5) in increasing regeneration, but thus far, no studies have investigated the effect of dipyridamole on liver regeneration. Cellular cyclic adenosine monophosphate (cAMP) is a secondary messenger, and has an important role in cellular response to ischemia-reperfusion, toxic injury and surgical trauma.…”

Section: Introductionmentioning

confidence: 99%

Dipyridamole: A New Liver Regeneration Agent

Esin¹,

Karaalı²,

Emiroğlu³

et al. 2019

TERH

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Objective: We assessed the effect of dipyridamole, a phosphodiesterase inhibitor, on liver regeneration in experimentally hepatectomized rats. Methods: Sixty Wistar-Albino rats were divided into two groups as control and study groups. Each group has been divided into three subgroups containing 10 rats each. After 70% liver resection has been performed to the rats, upon resection dipyridamole infusion to the study group and 0.9% NaCl infusion to the control group has been done. Rats were allowed to survive for 24, 48, and 72 h and then they were sacrificed. Relative liver weight, AST, ALT, ALP, albumin and PT were measured. Histopathologic assessment was obtained by mitotic index and proliferating cell nuclear antigen (PCNA) labeling index. Results: There were statistically significant differences between study and control groups in ALP and relative liver weights at 24, 48, and 72 h (p<0.05). There were also statistically significant differences between the groups in PT and albumin levels at 48 h for PT, and 24 h and 72 h for albumin levels (p<0.05). There were no statistically significant differences between study and control groups in AST and ALT at 48 h (p>0.05). Mitotic index and PCNA labeling index were significantly higher in study group for each time period (p<0.05). Conclusion: The dipyridamole exogenously applied after partial hepatectomy has provided improvement in morphological, biochemical and histopathological parameters.

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Silymarin Accelerates Liver Regeneration after Partial Hepatectomy

Cited by 21 publications

References 35 publications

Silymarin improved diet-induced liver damage and insulin resistance by decreasing inflammation in mice

Silymarin improved diet-induced liver damage and insulin resistance by decreasing inflammation in mice

Effects of lactulose and silymarin on liver enzymes in cirrhotic rats

Dipyridamole: A New Liver Regeneration Agent

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