Silver nanoparticles exert toxic effects in human monocytes and macrophages associated with the disruption of Δψm and release of pro-inflammatory cytokines

Sousa, Adelaide; Rufino, Ana T.; Fernandes, Rui; Malheiro, Ana; Carvalho, Félix; Fernandes, Eduarda; Freitas, Marisa

doi:10.1007/s00204-022-03415-x

Cited by 3 publications

(3 citation statements)

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“…However, some AgNP coatings can also affect their toxicity. (Guo et al 2016 ; Soares et al 2016 ; Cho et al 2018 ; Ferdous and Nemmar 2020 ; Sousa et al 2022 , 2023 ). The human dietary intake of silver (Ag), resulting from the widespread use of AgNP, has been estimated to be 70–90 μg/day (Zorraquín-Peña et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…This can be attributed to the fact that smaller AgNP have a larger surface area to volume ratio. As a result, they can interact more effectively with biological molecules, leading to enhanced cellular uptake, which may result in increased toxicity (Guo et al 2016 ; Soares et al 2016 ; Cho et al 2018 ; Ferdous and Nemmar 2020 ; Sousa et al 2022 , 2023 ). Coatings, as polyvinylpyrrolidone (PVP), are often used to stabilize AgNP and prevent aggregation.…”

Section: Introductionmentioning

confidence: 99%

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Biodistribution and intestinal inflammatory response following voluntary oral intake of silver nanoparticles by C57BL/6J mice

Sousa,

Azevedo,

Costa

et al. 2023

Arch Toxicol

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Silver nanoparticles (AgNP) are among the most widely commercialized nanomaterials globally, with applications in medicine and the food industry. Consequently, the increased use of AgNP in the food industry has led to an unavoidable rise in human exposure to these nanoparticles. Their widespread use raises concerns about potential hazards to human health, specifically their intestinal pro-inflammatory effects. Thus, the main objective of this study was to evaluate the biological effects of two subacute doses of 5 nm polyvinylpyrrolidone (PVP)-AgNP in C57BL/6J mice. One mg/kg body weight or 10 mg/kg bw was provided once a day for 14 days, using a new technology (HaPILLness) that allows voluntary, stress-free, and accurate oral dosing. It was observed that after oral ingestion, while AgNP is biodistributed throughout the entire organism, most of the ingested dose is excreted in the feces. The passage and accumulation of AgNP throughout the intestine instigated a prominent inflammatory response, marked by significant histological, vascular, and cellular transformations. This response was driven by the activation of the nuclear factor-кB (NF-кB) inflammatory pathway, ultimately leading to the generation of multiple cytokines and chemokines.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biodistribution and intestinal inflammatory response following voluntary oral intake of silver nanoparticles by C57BL/6J mice

Sousa,

Azevedo,

Costa

et al. 2023

Arch Toxicol

Self Cite

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“…Thus, it can be assumed that using silver nanoparticle solutions for NPWTi is possible, depending on the phase of the wound process. However, it should be considered that AgNPsmay has cytotoxicity [13].…”

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confidence: 99%

Dynamics of indicators of the prooxidant-antioxidant system in the blood and exudate under the treatment of purulent wounds with negative pressure and silver nanoparticles

Малышко¹,

Басов²,

Dorohova³

et al. 2023

Medical news of the North Caucasus

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Changes in hematological parameters when using silver preparations in laboratory ICR mice infected with the Newcastle disease virus

Sumarokova,

Statsevich,

Afonyushkin

et al. 2024

jour

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The results of blood tests are important indicators for assessing and monitoring the health status, adaptation processes and metabolic states of the body. Currently, there is insufficient data on the effect of the Newcastle disease virus on peripheral blood parameters in animals, and there is also no information on changes in these parameters during Newcastle disease and the simultaneous use of silver preparations in animals. Although the mechanisms of the antiviral action of silver nanoparticles are not yet fully studied, researches show their effectiveness. The purpose of research was to study changes in hematological parameters with using silver preparations in laboratory ICR mice infected with Newcastle disease virus. The object of the study was the blood of laboratory ICR mice, infected with the Newcastle disease virus, and healthy ones as a control, and also silver preparations: Argosil and ArgovitMaxi. As a result of hematological studies, a significant effect of the Newcastle disease virus on hematological parameters was established. Deviations of the main blood parameters in infected animals were demonstrated: there was an increase in the content of granulocytes, the number of erythrocytes, the hemoglobin content and hematocrit; the number of lymphocytes and the average erythrocytes volume were reduced. It was also found that the use of the preparation Argosil significantly reduces the content of monocytes in ICR mice against the background of Newcastle disease viral infection. The use of the preparation Argovit significantly affects the decrease in monocytes and erythrocyte blood parameters: it increases the number of erythrocytes, hemoglobin, hematocrit, and reduces the average hemoglobin content in an erythrocyte, the average hemoglobin concentration in an erythrocyte.

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Silver nanoparticles exert toxic effects in human monocytes and macrophages associated with the disruption of Δψm and release of pro-inflammatory cytokines

Cited by 3 publications

References 49 publications

Biodistribution and intestinal inflammatory response following voluntary oral intake of silver nanoparticles by C57BL/6J mice

Biodistribution and intestinal inflammatory response following voluntary oral intake of silver nanoparticles by C57BL/6J mice

Dynamics of indicators of the prooxidant-antioxidant system in the blood and exudate under the treatment of purulent wounds with negative pressure and silver nanoparticles

Changes in hematological parameters when using silver preparations in laboratory ICR mice infected with the Newcastle disease virus

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