Silver Nanoparticles Coated Poly(L-Lactide) Electrospun Membrane for Implant Associated Infections Prevention

Wang, Jiaolong; Zhan, Lilin; Zhang, Xianhua; Wu, Runfa; Lan, Lei; Wei, Junchao

doi:10.3389/fphar.2020.00431

Cited by 27 publications

(25 citation statements)

References 34 publications

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“…This effect can be achieved by modifying the membrane's structure or by adding components able to exert this function. Some of the components that have been described are metal, ions like zinc, copper or silver [1,17,37], or antibiotics, like metronidazole or doxycycline [38][39][40]. In order to assay the membrane's antibacterial effect, the protocol described by Bueno et al [39], perfectly meets the required tests.…”

Section: Antibacterial Effect Of the Materialsmentioning

confidence: 99%

Testing active membranes for bone regeneration: A review

Toledano

Manzano-Moreno

Ruíz

et al. 2021

Journal of Dentistry

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Section: Antibacterial Effect Of the Materialsmentioning

confidence: 99%

Testing active membranes for bone regeneration: A review

Toledano

Manzano-Moreno

Ruíz

et al. 2021

Journal of Dentistry

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“…In this context, electrospinning represents a simple and cost-effective process to obtain, from a wide range of polymers, drug release devices with high porosity, high surface area, and nanoscale-sized fibers [ 22 ]. Electrospun loaded membranes for the treatment of peri-implantitis have been previously reported [ 23 , 24 ]. Li et al and Zhang et al fabricated poly(lactic-co-glycolic) acid (PLGA) nanofibers able to release gentamicin and vancomycin, respectively, that can prevent implanted-related infections [ 21 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

pH-Responsive Resveratrol-Loaded Electrospun Membranes for the Prevention of Implant-Associated Infections

Bonadies

Cristo²,

Valentino³

et al. 2020

Nanomaterials

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To date, the implant-associated infections represent a worldwide challenge for the recently reported bacterial drug resistance that can lead to the inefficacy or low efficacy of conventional antibiotic therapies. Plant polyphenolic compounds, including resveratrol (RSV), are increasingly gaining consensus as valid and effective alternatives to antibiotics limiting antibiotic resistance. In this study, electrospun polylactic acid (PLA) membranes loaded with different concentrations of RSV are synthesized and characterized in their chemical, morphological, and release features. The obtained data show that the RSV release rate from the PLA-membranes is remarkably higher in acidic conditions than at neutral pH. In addition, a change in pH from neutral to slightly acidic triggers a significant increase in the RSV release. This behavior indicates that the PLA-RSV membranes can act as drug reservoir when the environmental pH is neutral, starting to release the bioactive molecules when the pH decreases, as in presence of oral bacterial infection. Indeed, our results demonstrate that PLA-RSV2 displays a significant antibacterial and antibiofilm activity against two bacterial strains, Pseudomonas aeruginosa PAO1, and Streptococcus mutans, responsible for both acute and chronic infections in humans, thus representing a promising solution for the prevention of the implant-associated infections.

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“…However, the Young’s modulus and the ultimate strength were reduced by the incorporation of FG and strengthened by further the incorporation of BR nanoparticles [ 76 ]. In the mussel-inspired method of Wang et al, a poly-L-lactic acid (PLLA) membrane was treated with dopamine to form polydopamine (PDA) coated PLLA, and PLLA was then coated with AgNPs using the reduction effect of PDA, which imparted antimicrobial activity to the modified membrane [ 77 ].…”

Section: Resultsmentioning

confidence: 99%

Advances in Modification Methods Based on Biodegradable Membranes in Guided Bone/Tissue Regeneration: A Review

et al. 2022

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Guided tissue/bone regeneration (GTR/GBR) is commonly applied in dentistry to aid in the regeneration of bone/tissue at a defective location, where the assistive material eventually degrades to be substituted with newly produced tissue. Membranes separate the rapidly propagating soft tissue from the slow-growing bone tissue for optimal tissue regeneration results. A broad membrane exposure area, biocompatibility, hardness, ductility, cell occlusion, membrane void ratio, tissue integration, and clinical manageability are essential functional properties of a GTR/GBR membrane, although no single modern membrane conforms to all of the necessary characteristics. This review considers ongoing bone/tissue regeneration engineering research and the GTR/GBR materials described in this review fulfill all of the basic ISO requirements for human use, as determined through risk analysis and rigorous testing. Novel modified materials are in the early stages of development and could be classified as synthetic polymer membranes, biological extraction synthetic polymer membranes, or metal membranes. Cell attachment, proliferation, and subsequent tissue development are influenced by the physical features of GTR/GBR membrane materials, including pore size, porosity, and mechanical strength. According to the latest advances, key attributes of nanofillers introduced into a polymer matrix include suitable surface area, better mechanical capacity, and stability, which enhances cell adhesion, proliferation, and differentiation. Therefore, it is essential to construct a bionic membrane that satisfies the requirements for the mechanical barrier, the degradation rate, osteogenesis, and clinical operability.

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Silver Nanoparticles Coated Poly(L-Lactide) Electrospun Membrane for Implant Associated Infections Prevention

Cited by 27 publications

References 34 publications

Testing active membranes for bone regeneration: A review

Testing active membranes for bone regeneration: A review

pH-Responsive Resveratrol-Loaded Electrospun Membranes for the Prevention of Implant-Associated Infections

Advances in Modification Methods Based on Biodegradable Membranes in Guided Bone/Tissue Regeneration: A Review

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