Silver nanoparticle-coated suture effectively reduces inflammation and improves mechanical strength at intestinal anastomosis in mice

Tannic acid-modified silver nanoparticles for wound healing: the importance of size

“…Wound dressings containing AgNPs can effectively protect an injury from bacterial infection and promote tissue regeneration during the wound healing process. 9,10 Plantbased products have been used to treat wounds for centuries due to their antioxidant, anti-inflammatory and antimicrobial effects. TA has been shown to stabilize collagen and elastin in the extracellular matrix.…”

“…7,8 Wound dressings containing AgNPs have also been suggested to enhance wound healing by decreasing the inflammatory response. 9,10 Tannins are plant phenol derivatives of various molecular weights naturally synthesized by plants as metabolic products. [11][12][13] Tannic acid (TA, penta-m-digalloyl glucose) is the simplest and principal hydrolyzable tannin that has astringent, antioxidant, antimicrobial, antiviral and antiinflammatory properties.…”

Current Development of Silver Nanoparticle Preparation, Investigation, and Application in the Field of Medicine

“…Moreover, decreased inflammatory cell infiltration and goblet cell hyperplasia were also observed [73]. Further evidence of the antiinflammatory effects of AgNPs has been demonstrated in a postoperative peritoneal adhesion model and through the use of AgNP-coated sutures [74,75]. Wong et al found that AgNPs are effective at decreasing inflammation in peritoneal adhesions without significant cytotoxic effects while Zhang et al reported that using AgNP-coated sutures decreased inflammation and improved mechanical strength at intestinal anastomosis in mice [74,75].…”

“…Further evidence of the antiinflammatory effects of AgNPs has been demonstrated in a postoperative peritoneal adhesion model and through the use of AgNP-coated sutures [74,75]. Wong et al found that AgNPs are effective at decreasing inflammation in peritoneal adhesions without significant cytotoxic effects while Zhang et al reported that using AgNP-coated sutures decreased inflammation and improved mechanical strength at intestinal anastomosis in mice [74,75]. Our previous studies have also demonstrated that AgNP/poly(lactic-coglycolic acid) (PLGA-) coated stainless steel alloy (SNPSA) materials significantly reduced bacterial infection and inflammatory cell infiltration in the intramedullary tissue in rat femoral canals (Figure 1) [76].…”

Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

“…Failure to do so can have possibly irreversible consequences, including tissue scarring, chronic inflammation, and infection (Guirao and Lowry, 1996;Martin, 1997;Branton and Kopp, 1999;Wahl, 1999;Dunn et al, 2001;Eming et al, 2007). Recent in vitro and in vivo work has pointed toward the unprecedented ability of AgNP to reduce inflammatory macrophage and neutrophil infiltration, to inhibit the production of inflammatory cytokines, and to regulate the expression of metalloproteinases (Wright et al, 2002;Bhol and Schechter, 2007;Tian et al, 2007;Wong et al, 2009;Liu et al, 2010;Zhang et al, 2014). Thus, it stands that the incorporation of AgNP in biomaterial dressings is expected not only to add an antimicrobial element to the scaffold but also to further improve wound healing (Lu et al, 2012a;Neibert et al, 2012;Fan et al, 2014;Herron et al, 2014).…”