Silver ions are responsible for memory impairment induced by oral administration of silver nanoparticles

Wesierska, M; Dziendzikowska, Katarzyna; Gromadzka-Ostrowska, Joanna; Dudek, J.; Polkowska-Motrenko, Halina; Audinot, Jean‐Nicolas; Gutleb, Arno C.; Lankoff, Anna; Kruszewski, Marcin

doi:10.1016/j.toxlet.2018.03.019

Cited by 48 publications

(53 citation statements)

References 57 publications

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“…[124,125] Up to now, lines evidence has demonstrated that nanomaterials enter into brain through different exposure routes including inhalation, injection, and gavage. [120,126,127] Therefore, brain is an important target of nanomaterials even by oral administration through gut-brain axis. For the gut-brain axis, it is a twoway regulatory network between the brain and gut.…”

Section: Structure Of Blood-brain Barrier and Concept Of Gut-brain Axismentioning

confidence: 99%

“…[129] Accumulated nanomaterials can directly disturb the secretion of neurotransmitters in the brain, [126] or worse, affect the behavior and memory in host after longterm expo sure to NMs. [127] Therefore, the distant effects of nanomaterials on brain through gut-brain axis deserve more attention.…”

Section: Effects Of Nanomaterials On Central Nervous System Through Gmentioning

confidence: 99%

“…[126,136,137] Intriguingly, Ag NMs accumulated in the hippocampus dramatically downregulated the expression of synaptic proteins synapsin I, synaptophysin, and PSD95, which induced serious impairment on the synapses in the hip pocampus. [127,138] The myelin sheath is located on the surface of axons and used to insulate and maintain the normal conduc tion of nerve impulses. Ag NMs could affect myelin ultrastruc ture and decreased the expression of myelinspecific proteins, such as 2′3′cyclic nucleotide 3′phosphodiesterase (CNP), myelinassociated glycoprotein (MAG), and myelin/oligoden drocyte glycoprotein (MOG), caused toxicity of central nervous system.…”

Section: Effects Of Nanomaterials On Central Nervous System Through Gmentioning

confidence: 99%

See 2 more Smart Citations

The Nano–Intestine Interaction: Understanding the Location‐Oriented Effects of Engineered Nanomaterials in the Intestine

Cui

Bao

Wang

et al. 2020

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/smll.201907665. Engineered nanomaterials (ENMs) are used in food additives, food packages, and therapeutic purposes owing to their useful properties, Therefore, human beings are orally exposed to exogenous nanomaterials frequently, which means the intestine is one of the primary targets of nanomaterials. Consequently, it is of great importance to understand the interaction between nanomaterials and the intestine. When nanomaterials enter into gut lumen, they inevitably interact with various components and thereby display different effects on the intestine based on their locations; these are known as location-oriented effects (LOE). The intestinal LOE confer a new biological-effect profile for nanomaterials, which is dependent on the involvement of the following biological processes: nanomucus interaction, nano-intestinal epithelial cells (IECs) interaction, nanoimmune interaction, and nano-microbiota interaction. A deep understanding ofNM-induced LOE will facilitate the design of safer NMs and the development of more efficient nanomedicine for intestine-related diseases. Herein, recent progress in this field is reviewed in order to better understand the LOE of nanomaterials. The distant effects of nanomaterials coupling with microbiota are also highlighted. Investigation of the interaction of nanomaterials with the intestine will stimulate other new research areas beyond intestinal nanotoxicity. www.advancedsciencenews.com

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Section: Structure Of Blood-brain Barrier and Concept Of Gut-brain Axismentioning

confidence: 99%

Section: Effects Of Nanomaterials On Central Nervous System Through Gmentioning

confidence: 99%

Section: Effects Of Nanomaterials On Central Nervous System Through Gmentioning

confidence: 99%

See 1 more Smart Citation

The Nano–Intestine Interaction: Understanding the Location‐Oriented Effects of Engineered Nanomaterials in the Intestine

Cui

Bao

Wang

et al. 2020

Small

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“…Neurotoxicity and impaired BBB functions were also observed after intraperitoneal administration attributed to the change of level of trace element in serum and brain, reduction of antioxidant enzyme activity, apoptosis and induction of inflammatory processes and down regulated tight junction proteins expression [100]. Similarly, chronic, intragastrically exposure of rats to low doses of Ag NPs resulted in the presence of silver in various parts of the brain, including the hippocampus and impairment of hippocampal dependent memory and cognitive coordination processes [101]. In contrast Dąbrowska-Bouta et al showed in their studies on male Wistar rats that Ag NPs administered in low concentration did not cause visible neurotoxicity in behavioral tests; however, more accurate studies showed abnormalities in the myelin sheaths and an altered expression of myelin proteins [102].…”

Section: In Vivo Toxicity In Mammalsmentioning

confidence: 99%

Toxicity of metallic nanoparticles in the central nervous system

Sawicki

Czajka

Matysiak‐Kucharek

et al. 2019

Nanotechnology Reviews

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Metallic nanoparticles due to their small size and unique physico-chemical characteristics have found excellent applications in various branches of industry and medicine. Therefore, for many years a growing interest has been observed among the scientific community in the improvement of our understanding of the impact of nanoparticles on the living organisms, especially on humans. Considering the delicate structure of the central nervous systemit is one of the organs most vulnerable to the adverse effects of metallic nanoparticles. For that reason, it is important to identify the modes of exposure and understand the mechanisms of the effect of nanoparticles on neuronal tissue. In this review, an attempt is undertaken to present current knowledge about metallic nanoparticles neurotoxicity based on the selected scientific publications. The route of entry of nanoparticles is described, as well as their distribution, penetration through the cell membrane and the blood-brain barrier. In addition, a study on the neurotoxicity in vitro and in vivo is presented, as well as some of the mechanisms that may be responsible for the negative effects of metallic nanoparticles on the central nervous system. Graphical abstract: This review summarizes the current knowledge on the toxicity of metallic NPs in the brain and central nervous system of the higher vertebrates.

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“…The adverse effects of AgNPs exposure on memory and spatial learning have been previously studied in different models and some of them with a major focus on prenatal exposure [30,31]. Recently, Węsierska et al reported that oral gavage with a dose of 1 mg/kg of AgNPs produced adverse effect on memory and cognitive function [32]. In addition, Antsiferova et al investigated the effects of the prolonged oral administration of PVP-coated AgNPs at the dosage of 50 μg per day demonstrating impairment of long-term memory [33].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Silver Nanoparticles on Learning, Memory and Social Interaction in BALB/C Mice

Greish

Alqahtani

Alotaibi

et al. 2019

IJERPH

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Silver Nanoparticles (AgNPs), an epitome of nanotechnology, appear in everyday products such as water filters, printer ink, toothpaste, food packaging and cosmetics mostly due to their bactericidal properties. Given this high level of public exposure, the safety of AgNPs has never been fully established. The unsafe use of AgNPs could pose a real threat, not only to public health but also to economic growth in many industries. In this paper, we tested the effect of AgNPs on memory, learning, social behaviour and motor function of BALB/C mice. Outcomes of the present study suggested an impairment of these functions in AgNPs treated groups. Overall, obtained data support the evidence that the systemic exposure to AgNPs may result in alteration of the cerebral cognition and warrants further consideration on the impact of the AgNPs on human health with respect to their potential neurotoxicity.

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Silver ions are responsible for memory impairment induced by oral administration of silver nanoparticles

Cited by 48 publications

References 57 publications

The Nano–Intestine Interaction: Understanding the Location‐Oriented Effects of Engineered Nanomaterials in the Intestine

The Nano–Intestine Interaction: Understanding the Location‐Oriented Effects of Engineered Nanomaterials in the Intestine

Toxicity of metallic nanoparticles in the central nervous system

The Effect of Silver Nanoparticles on Learning, Memory and Social Interaction in BALB/C Mice

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