Silk fibroin aerogels for drug delivery applications

Marin, Michael A.; Mallepally, Rajendar R.; McHugh, Mark A.

doi:10.1016/j.supflu.2014.04.014

Cited by 101 publications

(51 citation statements)

References 32 publications

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“…Section 2.4) are being actively studied as drug carriers for pharmaceutical purposes since they combine their availability, renewability and myriad of chemical functionalities with the biodegradability that silica aerogels lack [18]. The use of bio-based aerogels for drug delivery purposes has been reported from different sources like polysaccharides (starch, alginate, pectin, chitosan, cellulose) [170-172, 200, 204, 210-212], proteins (whey protein, silk fibroin) [30,213] or hybrids (gelatin-silica, cellulose-polyethyleneimine, chitosan-silica) [202,214,215].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Enhanced drug dissolution and fast release (30-60 min) in the GI tract can be typically obtained from drugs loaded in silica aerogels in a non-crystalline form, although the profile will depend on the drug itself and its interaction with the aerogel matrix [201,202]. For a more sustained release, the use of derivatized silica aerogels or bio-based aerogels are reported [30,171,201,213]. Hydrophobic silica aerogels are more stable against disintegration than hydrophilic silica aerogels and the drug payload is released in a more prolonged release pattern mainly governed by diffusion [201].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Synthesis and biomedical applications of aerogels: Possibilities and challenges

Maleki

Durães

García‐González

et al. 2016

Advances in Colloid and Interface Science

296

192

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Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

Synthesis and biomedical applications of aerogels: Possibilities and challenges

Maleki

Durães

García‐González

et al. 2016

Advances in Colloid and Interface Science

296

192

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“…Solubilization and regeneration is necessary for use this biomaterial for tissue engineering, like scaffolding. Usually the fibroin is processed in a solution of LiBr [166,167], in a ternary solvent composed by Calcium Chloride / Ethanol / Water to break fiber to fiber bond [168] or by SDS [168,169]. This allows the casting of the polymer and the consequent creation of different structure for geometrical complexity.…”

Section: Drug Delivery Applicationsmentioning

confidence: 99%

History and Applications of Hydrogels

Yahia¹

2015

J Biomed Sci

160

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Hydrogels have existed for more than half century, providing one of the earliest records of crosslinked hydroxyethyl methacrylate (HEMA) hydrogels. Today, hydrogels still fascinate material scientists and biomedical researchers and great strides have been made in terms of their formulations and applications. As a class of material, hydrogels are unique, they consist of a self-supporting, waterswollen three-dimensional (3D) viscoelastic network which permits the diffusion and attachment of molecules and cells. However, hydrogels have recently drawn great attention for use in a wide variety of biomedical applications such as cell therapeutics, wound healing, cartilage/bone regeneration and the sustained release of drugs. This is due to their biocompatibility and the similarity of their physical properties to natural tissue. This review aims to give an overview of the historic and the recent design concept of hydrogels and their several applications based on the old and the most recent publications in this field. Journal of Biomedical Sciences ISSN 2254-609XThis Article is Available in: www.jbiomeds.com 2 Hydrogels can be classified into two distinct categories, the natural and the synthetic hydrogels. Natural hydrogels include collagen, fibrin, hyaluronic acid, matrigel, and derivatives of natural materials such as chitosan, alginate and skill fibers. They remain the most physiological hydrogels as they are components of the extracellular matrix (ECM) in vivo. Two main drawbacks of natural hydrogels, however, make their final microstructures and properties difficult to control reproducibly between experiments. First, the fine details of their mechanical properties and their dependence on polymerization or gelation conditions are often poorly understood. Second, due to their natural origin (bovine fibrinogen, rat tail collagen… their composition may vary from one batch to another.In contrast, synthetic hydrogels such as poly (ethylene glycol) diacrylate, poly(acryl amide), poly(vinyl alcohol) are more reproducible, although their final structure can also depend on polymerization conditions in a subtle way, so that a rigorous control of the preparation protocol, including temperature and environment control, may be necessary. Generally speaking, synthetic hydrogels offer more flexibility for tuning chemical composition and mechanical properties; users can, for example vary the concentration or molecular weight of the precursor, or alter the percentage of crosslinkers. They can also be selected or tuned to be hydrolysable or biodegradable over variable periods of time.Hydrogels may be chemically stable or they may degrade and eventually disintegrate and dissolve. They are called «reversible» or «physical» gels when the networks are held together by molecular entanglements, and/or secondary forces including ionic, H-bonding or hydrophobic forces (Figure 2) [3]. Physical hydrogels are not homogeneous, since clusters of molecular entanglements, or hydrophobically-or ionically-associated domains, can create in h...

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“…6 confirm that the two SF aerogels exhibit similar morphologies with highly porous structures and an interconnected network of nanofibrils. Further studies are in progress on the elucidation of SF aerogel characteristics and potential applications as scaffolds for cell growth and drug delivery [38].…”

Section: Effect Of Co 2 Mass Transfer On the Sol-gel Kinetics Of Silkmentioning

confidence: 99%