Silica Granuloma of the Skin

Epstein, Ervin

doi:10.1001/archderm.1955.01540250026006

Cited by 38 publications

(15 citation statements)

References 9 publications

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“…The SS White pumice stone and the abrasive powder of the finishing and polishing 3M sandpaper produced discrete to moderate forms of lympho-plasmocytes in all samples at all times. These findings are in agreement with the literature (3)(4)(5)(7)(8)(9)11,(13)(14)(15). The presence of lympho-plasmocyte cells is also reported by Daley and Wisocki (1) and Gordon and Daley (2) where foreign particles frequently containing calcium, silicon and aluminum were found in the interior of gingival tissues.…”

Section: Discussionsupporting

confidence: 92%

“…Many authors (4,6,12,13) consider that substances containing silica produce granulomatous lesions only after many years. This latency period is believed to be due to the theory that gross silica, such as the one present in sand, does not present a potential to induce this type of alteration.…”

Section: Discussionmentioning

confidence: 99%

“…Those containing silicon (especially in the form of silica) have been receiving the most attention from researchers. When implanted in the human soft tissues, these substances have been associated with the development of foreign body granulomas (3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

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Submucous implant of abrasive dental materials in rat tongues: clinical and histological evaluation

Pistóia

Figueiredo

2002

Braz. Dent. J.

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This study evaluated the clinical and histological manifestations produced by the submucuous implant of abrasive dental materials in the rat tongue. A total of 128 rats were divided into 4 groups of 32 rats each, according to the material selected for the implant: Herjos-F prophylactic paste both in its normal composition as well as lacking its abrasive components, SS White pumice stone and the abrasive powder of the 3M finishing and polishing sandpaper. The specimens were submitted to clinical and histological analyses at 30, 60, 90 and 120 days. After 90 days, the formation of nodular lesions in animals implanted with materials containing abrasive substances was observed. Histologically, these materials produced marked chronic granulomatous reactions. Herjos-F prophylactic paste produced the greatest reaction. However, without the abrasive components, this paste caused the mildest tissue reactions, with no inflammatory response, that was seen in a progressively greater number of cases after 90 days.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Submucous implant of abrasive dental materials in rat tongues: clinical and histological evaluation

Pistóia

Figueiredo

2002

Braz. Dent. J.

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“…These particles are doubly refractile when examined under polarized light 7 . With the exception of the case reported by Shattock, all the cases reported of silica or silicon granuloma were at scar sites 1,3–6 . These were due to silica material being introduced into wounds or where silicone injections were given for cosmetic reasons.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous silica granuloma with generalized involvement of lymph nodes

Hou

Zhu

2011

The Journal of Dermatology

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We report a case of cutaneous silica granuloma with generalized involvement of distal lymph nodes; no similar case has been reported in the published work. The 45-year-old man was a stonemason who had been incidentally sprayed with rock dust from a saw 22 years ago. The subject presented with nodules and erythematous areas on his face and chin. In addition, there was swelling in the cervical and inguinal lymph nodes. An excised lymph node had normal architecture with numerous non-caseating epithelioid cell granuloma and silicotic nodules which contained scattered, multinucleated, giant cells. There were particles in the granuloma exhibiting birefringence under polarized light microscopy. Elemental X-ray spectra of these lesions showed the presence of silica in these granulomas.

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“…Excision is the most common method mentioned, although patients who appear to have had adequate excision may develop recurrences (2,21). Since spontaneous resolution (8,20) and response to either systemic (22) or intralesional steroid therapy is possible (2), surgery must be reserved for persistent lesions (2). However, there have been recurrences after intralesional corticosteroid treatment (6,21).…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Silica Granuloma in a Child

Kaya¹,

Köktürk²,

Polat

et al. 2003

Pediatric Dermatology

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A 12-year-old girl had a 4-year history of two asymptomatic, sharply demarcated, granulomatous lesions on her face. The lesions did not respond to topical steroids and histopathologic examination of biopsy specimens showed granulomatous inflammation. Since cutaneous leishmaniasis is endemic where the patient lived, she was diagnosed as chronic cutaneous leishmaniasis but did not respond to meglumine antimoniate treatment. Reexamination of the biopsy specimens under polarized light revealed numerous birefringent crystalline particles, and cutaneous silica granuloma was the final diagnosis. The lesions were treated with intralesional triamcinolone acetonide and completely disappeared. We report this case of cutaneous silica granuloma, which is unusual in children, and emphasize the importance of polarized light microscopic examination of granulomatous skin diseases.

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Silica Granuloma of the Skin

Cited by 38 publications

References 9 publications

Submucous implant of abrasive dental materials in rat tongues: clinical and histological evaluation

Submucous implant of abrasive dental materials in rat tongues: clinical and histological evaluation

Cutaneous silica granuloma with generalized involvement of lymph nodes

Cutaneous Silica Granuloma in a Child

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