Silica-based nanoparticles as drug delivery systems

Karaman, Didem Şen; Kettiger, Hélène

doi:10.1016/b978-0-12-813661-4.00001-8

Cited by 17 publications

(15 citation statements)

References 142 publications

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“…Mesoporous silica materials have attracted a great scientific interest in various fields owing to their unique characteristics. Structural properties include uniform and tunable pore size (typically within the range of 2–6 nm), uniform and tunable nanoparticle size (50–200 nm) and shape, possibility of surface functionalization, high surface area (700–1000 m 2 /g), large pore volume (>0.9 cm 3 /g), and control over the structure of the pore networks and the gating mechanism of pore openings [ 9 , 15 , 16 ]. Moreover, these nanocarriers are resistant to pH, heat, mechanical stress, and hydrolysis-induced degradations; have bifunctional surfaces, as they possess an internal surface and an external surface; and their fabrication is simple and cost-efficient [ 9 , 12 ].…”

Section: Characteristics Of Mesoporous Silica Materialsmentioning

confidence: 99%

“…Subsequently, the Santa Barbara amorphous type materials, including SBA-11 (cubic), SBA-12 (3D hexagonal), SBA-15 (hexagonal), and SBA-16 (cubic-cage structures), which have larger pores and thicker silica walls, have been synthesized by the University of California, Santa Barbara. Furthermore, other synthesized MSN are FSM-16 (folded sheets of mesoporous materials); TUD-1 (Technical Delft University); HMM-33 (Hiroshima Mesoporous Material); COK-12 (Centrum voor Oppervlaktechemie en Katalyse/Centre for Research Chemistry and Catalysis); and FDU-2, -11, -12, -13 (Fudan University) [ 15 , 21 , 22 ]. Additionally, MSN can also be synthesized as hollow and rattle-type nanoparticles, which are interstitial hollow-spaced, mesoporous shells with low density and high surface area [ 21 ].…”

Section: Characteristics Of Mesoporous Silica Materialsmentioning

confidence: 99%

“…MSNs have been studied for a variety of applications, from nanoreactors for industrial catalytic reactions [ 13 ], to adsorbents, biosensors, drug delivery systems, gene carriers, phototherapy, and tissue engineering [ 13 , 15 , 16 ]. However, most studies focus on their use as drug nanocarriers, as they meet all the requirements, namely, biocompatibility, high loading capacity, no premature release, specific targeted delivery, and controlled release for an effective local drug concentration [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Mesoporous Silica Platforms with Potential Applications in Release and Adsorption of Active Agents

et al. 2020

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In recent years, researchers focused their attention on mesoporous silica nanoparticles (MSNs) owing to the considerable advancements of the characterization methods, especially electron microscopy methods, which allowed for a clear visualization of the pore structure and the materials encapsulated within the pores, along with the X-ray diffraction (small angles) methods and specific surface area determination by Brunauer–Emmett–Teller (BET) technique. Mesoporous silica gained important consideration in biomedical applications thanks to its tunable pore size, high surface area, surface functionalization possibility, chemical stability, and pore nature. Specifically, the nature of the pores allows for the encapsulation and release of anti-cancer drugs into tumor tissues, which makes MSN ideal candidates as drug delivery carriers in cancer treatment. Moreover, the inner and outer surfaces of the MSN provide a platform for further functionalization approaches that could enhance the adsorption of the drug within the silica network and the selective targeting and controlled release to the desired site. Additionally, stimuli-responsive mesoporous silica systems are being used as mediators in cancer therapy, and through the release of the therapeutic agents hosted inside the pores under the action of specific triggering factors, it can selectively deliver them into tumor tissues. Another important application of the mesoporous silica nanomaterials is related to its ability to extract different hazardous species from aqueous media, some of these agents being antibiotics, pesticides, or anti-tumor agents. The purpose of this paper is to analyze the methods of MSN synthesis and related characteristics, the available surface functionalization strategies, and the most important applications of MSN in adsorption as well as release studies. Owing to the increasing antibiotic resistance, the need for developing materials for antibiotic removal from wastewaters is important and mesoporous materials already proved remarkable performances in environmental applications, including removal or even degradation of hazardous agents such as antibiotics and pesticides.

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Section: Characteristics Of Mesoporous Silica Materialsmentioning

confidence: 99%

Section: Characteristics Of Mesoporous Silica Materialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mesoporous Silica Platforms with Potential Applications in Release and Adsorption of Active Agents

et al. 2020

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“…It has been used as a drug delivery system to improve the solubility and increase the bioavailability of poorly water-soluble drugs [44][45][46][47][48][49][50][51][52]. In this study, a nanoporous silica entrapped lipid-drug complex (NSC) was prepared to maximize the oral absorption of the poorly water-soluble drug, DUT.…”

Section: Introductionmentioning

confidence: 99%

Nanoporous Silica Entrapped Lipid-Drug Complexes for the Solubilization and Absorption Enhancement of Poorly Soluble Drugs

2021

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This study aims to examine the contribution of nanoporous silica entrapped lipid-drug complexes (NSCs) in improving the solubility and bioavailability of dutasteride (DUT). An NSC was loaded with DUT (dissolved in lipids) and dispersed at a nanoscale level using an entrapment technique. NSC microemulsion formation was confirmed using a ternary phase diagram, while the presence of DUT and lipid entrapment in NSC was confirmed using scanning electron microscopy. Differential scanning calorimetry and X-ray diffraction revealed the amorphous properties of NSC. The prepared all NSC had excellent flowability and enhanced DUT solubility but showed no significant difference in drug content homogeneity. An increase in the lipid content of NSC led to an increase in the DUT solubility. Further the NSC were formulated as tablets using D-α tocopheryl polyethylene glycol 1000 succinate, glyceryl caprylate/caprate, and Neusilin®. The NSC tablets showed a high dissolution rate of 99.6% at 30 min. Furthermore, NSC stored for 4 weeks at 60 °C was stable during dissolution testing. Pharmacokinetic studies performed in beagle dogs revealed enhanced DUT bioavailability when administered as NSC tablets. NSC can be used as a platform to develop methods to overcome the technical and commercial limitations of lipid-based preparations of poorly soluble drugs.

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“…Recently, the advancement of nanoparticles with unique chemical and physical properties for drug delivery system (DDS) application has been well established. Previously, these DDS encounter serious limitations, such as high dose requirement, low bioavailability and off-target effects (Sen & Kettiger, 2018). The innovative use of nanoparticles has transformed the formulation and delivery of drug (Rizvi & Saleh, 2018).…”

Section: Introductionmentioning

confidence: 99%

Effect of Surfactant, Solvent and Stirring Rate on the Synthesis of Silica Nanoparticles Entrapped Rifampicin

Zakaria

Shukor

Razak

2020

JCEIB

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In this study, silica nanoparticles entrapped with rifampicin has successfully been synthesized by using micelles entrapment approach. The goal of this study is to investigate the effects of synthesis parameters; surfactant (Tween 80), solvent (water) and stirring rate on the particles size and distribution of silica nanoparticles entrapped rifampicin. The results showed that without surfactant, larger mean particles (176.4 nm to 207.70 nm) of silica nanoparticles were produced while uniform and smaller spherical particles sizes (42.37 nm -70.44 nm) were formed with the addition of surfactant. But, when the amount of surfactant increased from 3.0 g to 9.0 g, larger silica nanoparticles with uniform size and thinner walls were observed until critical micelle concentration (CMC) of surfactant equivalent to 11.0 g was reached. The effect of water content shows the particle size slightly increased from 55.92 nm to 56.99 nm when the water content was increased from 150 mL to 200 mL, and decreased rapidly from 56.99 nm to 18.55 nm as the amount of water was increased from 200 mL to 350 mL. Meanwhile, for the effect of stirring rate, the mean particles sizes were recorded in the range of 39.11 to 80.15 nm. The largest size was observed at the lowest stirring rate (120 rpm) and the smallest size was observed at the highest stirring rate (520 rpm). The significant effect of these synthesis parameters can be used in developing a rational basis in tuning the size of silica nanoparticles for drug delivery system.

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Silica-based nanoparticles as drug delivery systems

Cited by 17 publications

References 142 publications

Mesoporous Silica Platforms with Potential Applications in Release and Adsorption of Active Agents

Mesoporous Silica Platforms with Potential Applications in Release and Adsorption of Active Agents

Nanoporous Silica Entrapped Lipid-Drug Complexes for the Solubilization and Absorption Enhancement of Poorly Soluble Drugs

Effect of Surfactant, Solvent and Stirring Rate on the Synthesis of Silica Nanoparticles Entrapped Rifampicin

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